Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Srebp2"”.
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Regulation of Protein Degradation at the Endoplasmic Reticulum
… transcription by the transcription factor SREBP2. As well as being tightly regulated by sterol levels, the cholesterol synthesis pathway is highly oxygen dependent; however, how oxygen levels affect the regulation of this pathway is largely unknown. Here, using a combination of fluorescent …
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
… enhanced cholesterol biosynthesis by recruiting Srebp2 and Pol II in the promoter regions of cholesterol biosynthesis genes. Supporting its function as a transcription co-activator, we found that Qki directly interacted with single-stranded DNA. Together, we propose that Qki-Srebp2–mediated …
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
… enhanced cholesterol biosynthesis by recruiting Srebp2 and Pol II in the promoter regions of cholesterol biosynthesis genes. Supporting its function as a transcription co-activator, we found that Qki directly interacted with single-stranded DNA. Together, we propose that Qki-Srebp2–mediated …
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Molecular and cellular aspects of the SREBP pathway
… and partial purification of tagged SREBP1 and SREBP2 CTDs and probing of a SCAP peptide array with the CTDs. Results from the SREBP2 probing were difficult to interpret due to insolubility issues with the protein, however, probing with SREBP1 revealed five potential binding sites which were …
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Insulin, Cholesterol and A-beta: Roles and Mechanisms in Alzheimer’s disease
… sterol regulatory element binding protein-2 (SREBP2) up-regulation. Aβ caused insulin resistance in N2a-APP cells by phosphorylating IRS-1 at Ser612, inhibiting signaling to downstream targets. Aβ1-42-treated SHY exhibited similar IRS-1 phosphorylation at Ser612 and inflammatory response of …
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Detection of periodontal bacteria in atherosclerotic plaque
… the major cholesterogenic transcriptions factor, SREBP2 and its two target transcripts, LDLR and HMGR. Similarly, the cholesterol transporter gene ABCA1 was highly expressed in P. acnes-infected THP-1 cells in addition to inflammatory cytokines/chemokines TNFα, IL-1β, CCL3 (MIP-1α), cell adhesion …
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GPR50, a potential factor involved in psychiatric disorders interacts with Alzheimer’s disease-related protein β- secretase (BACE1)
… Among these interactors, RTN3, RTN4, SREBP2 and SNX6 are known regulators of β-secretase (BACE1), a key enzyme in Aβ generation, myelination of the central/peripheral nerve, and neurite outgrowth/synapse formation. Preliminary data indicated that GPR50 expression significantly …
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Identifying circulating biomarkers in a cohort of hypercholesterolaemic patients with statin intolerance from Gauteng, South Africa
… oxidative stress. Statins act as an activator of SREBP2, which can lead to increased miR-33a levels. As miR-33a negatively regulates ApoA-1, increased levels of miR-33a can reduce ApoA-1 levels. This can lead to reduced activity of ApoA-1 which hinders the removal of cholesterol from tissues. …