Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Src tyrosine kinase"”.
-
Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
Tks5 is a Src tyrosine kinase substrate and scaffolding protein for specialized cytoskeletal structures called podosomes/invadopodia. My doctoral thesis has focused on how Tks5 regulates the formation of these related structures and their impact on the invasive phenotype of cells. The podosomes of …
-
The Role of Traf6 Phosphorylation In Src/Traf6-Mediated Ikk, Jnk, Akt Activation and Tumorigenesis
… IGF-1, IL-1, LPS, and RANKL. We identify Src tyrosine kinase as a direct kinase for TRAF6 and a mediator of TRAF6 Y473 phosphorylation. Notably, we find that Src or Traf6 deficiency impairs IKK, Akt, and JNK activation, which can be rescued by phosphomimetic TRAF6, but not by …
-
Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
… I defined a genetic interaction between the src tyrosine kinase, Lyn, and the Ets family transcription factor, Ets1, in autoimmunity. Lyn is both a positive and negative regulator of BCR signaling; however its net effect is inhibitory. Lyn deficiency results in hyperactive B cells and Lyn-/- …
-
Function, expression and evolution of the *Src family kinases in Caenorhabditis elegans
<p>The vertebrate proto-oncogene, Src, is the prototype of a family of membrane-associated protein tyrosine kinases involved in cell signaling pathways that control cell growth, development, and differentiation. Activation of Src by mutation or overexpression has been implicated in a range of …
-
Targeting Opioid Receptor Signal Transduction to Produce Sustained Analgesia
… neurones for morphine analgesic tolerance; c-Src (a tyrosine kinase), thought to couple to MOP receptors through BAR2 has<br/>also been implicated.<br/><br/>To investigate opioid receptor signalling in response to morphine we used a variety of different techniques that included behavioural …
-
TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… and LFA-1KO mice. Furthermore, activation of the Src tyrosine kinase Lck also appears essential as PP2 abolished the rises. Downstream of Lck, both PI3K and PLC activation is necessary as their inhibition by LY294002 and edelfosine, respectively, abolished the rises. The rises do not involve store …
-
TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… and LFA-1KO mice. Furthermore, activation of the Src tyrosine kinase Lck also appears essential as PP2 abolished the rises. Downstream of Lck, both PI3K and PLC activation is necessary as their inhibition by LY294002 and edelfosine, respectively, abolished the rises. The rises do not involve store …
-
Purification and Activity of the PP60SRC Protein Kinase
… a molecular weight of 60,000 daltons (pp60<sup>src</sup>). The expression of pp60<sup>src</sup> results in many significant changes in the cell's phenotype which include disruption of the cytoskeleton and the deregulation of cell growth. During the last few years significant progress has been …