Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Src family kinases"”.
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Function, expression and evolution of the *Src family kinases in Caenorhabditis elegans
<p>The vertebrate proto-oncogene, Src, is the prototype of a family of membrane-associated protein tyrosine kinases involved in cell signaling pathways that control cell growth, development, and differentiation. Activation of Src by mutation or overexpression has been implicated in a range of …
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The role of SRC family kinases in the development and progression of prostate cancer
… of androgens, AR antagonists, protein kinases or bypassed altogether. Detailed knowledge of these processes should allow better understanding of molecular patterns, driving the progression of prostate cancer and, ultimately, could lead to the development of novel molecular targeted …
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Protein Tyrosine Phosphorylation in Haematopoietic Cancers and the Functional Significance of Phospho- Lyn SH2 Domain
… is involved in cancer. Dysregulation of tyrosine kinases (TKs) and protein-tyrosine phosphatases (PTPs) have been observed in multiple myeloma (MM) and acute myeloid leukemia (AML) and is a subject of study. Using recently developed mass spectrometry-based proteomics techniques, quantitative PTP …
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Role of Phosphorylation of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis
… FAK functions result from phosphorylation by Src family kinases, which trigger numerous signaling cascades. Overexpression of FAK is associated with metastasis in many solid tumors, including prostate cancer. Hence, understanding the mechanisms by which FAK is regulated in prostate cancer will …
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Epidermal Growth Factor Receptor Induces Fyn Expression Via Up-Regulation of P47Phox In Glioblastoma Multiforme
<p>Src family kinases (SFKs) are commonly over-expressed and/or activated in glioblastoma multiforme (GBM), where they serve as key mediators of GBM cell proliferation, survival, invasion and angiogenesis. Mechanisms of allosteric SFK activation are well described; however, the SFK Fyn is commonly …
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Mechanisms of TRAF Signaling
… activated by tumor necrosis factor (TNF) superfamily proteins. Ligands of the TNF family engage TNF receptor (TNFR) family proteins, leading to a wide variety of cellular effects, these interactions are implicated in inflammation, immune regulation, bone homeostasis, and development. TNFR …
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CHARACTERISATION OF A NOVEL SMALL MOLECULE INHIBITOR FOR IMMUNE ACTIVATION IN TRIPLE NEGATIVE BREAST CANCER
… function through Lyn kinase, a member of the Src family kinases. This current study characterised a novel immunomodulatory role for CHL-4, which is able to increase gene and protein expression of Type I/III IFNs in TNBC cell lines. This signalling is dependent on the RIG/MAVS cytosolic …
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Integrin-Mediated Mechanotransduction Controls Activation of Yap and Invasive Growth of Breast Cancer
… in which focal adhesion kinase (FAK) - Src family kinases (SFKs) serves as a hub to relay the mechanical cues from the ECM. We have investigated the mechanisms through which integrin signaling controls mammary tumorigenesis and found that integrin-mediated mechanotransduction controls …
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Investigating endothelin receptor B signalling during myelination
… by G protein‐coupled receptor (GPR) superfamily members. One GPR, Endothelin receptor B (EDNRB), best known for regulating blood flow, had previously been demonstrated to both positively and negatively influence myelination. I have investigated how EDNRB regulates myelination using an in …
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Dissection of spatiotemporal intracellular signaling using engineered chemical and genetic tools
… that modulate the allosteric regulation of Src Family Kinases (SFKs). SFKs are multi-domain kinases that transmit cellular signals through their catalytic and non-catalytic activities. Although dysregulation of kinases is often implicated in human diseases, studying individual kinases is …
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Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
… in 3D collagen matrices. We further show that Src family kinases (SFKs) are involved in this PKC [epsilon]-mediated EC lumen formation process. SFKs also interact with Cdc42 during EC lumen formation in a PKC [epsilon] dependent manner. Our analysis indicates that two members of SFKs, Src and …
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Investigating a co-operative link between TGF-β and Lyn kinase in Chronic Myeloid Leukaemia
… and activation of Lyn, a member of the Src family kinases (SFK). The main aim of the project was to investigate whether transforming growth factor-β (TGF) might influence drug-resistance through direct affects on Lyn kinase levels and its activation. This research builds on previous …
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CD148: a positive regulator of GPVI and \(\alpha\)II\(\beta\)3 proximal signalling in platelets
… work on elucidating the functions of tyrosine kinases in platelets, whereas protein tyrosine phosphatases (PTPs) have been under-investigated. To date, six non-transmembrane PTPs (NTPTPs), PTP-1B, Shp1, Shp2, MEG2-PTP, LMW-PTP and HePTP and a single receptor-like PTP (RPTP), CD148, have been …
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Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
<p>Fyn, a member of the Src family kinases, is an oncogene in murine epidermis and is associated with cell-cell adhesion turnover and migration. Introduction of active H-Ras(G12V) into the HaCaT human keratinocyte cell line resulted in upregulation of FYN mRNA (200-fold) and protein, but did not …
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The Role of Il-8-Mediated Src Family Kinase Activation In Tumor-Tumor and Tumor-Stromal Interactions In Metastasis of Prostate Cancer
… for PCa. Aberrant activation of protein tyrosine kinases, including Src Family Kinases (SFKs) contribute to metastasis through numerous functions, one of which leads to increased expression of cytokines, such as IL-8. However, the relationship between Src activity and IL-8 regulation is not …
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Lariat peptide inhibitors of Abl kinase
… indicated that the lariats do not recognize Src family kinases, which share a high structural similarity with Abl kinase in their active conformation. These findings, coupled with preliminary results from modeling studies, strongly suggest that the lariats have identified novel allosteric …
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Combination of Dasatinib and Dexamethasone targets the myeloma plasma cell through its interaction with the bone marrow microenvironment
… tyrosine kinase inhibitor, inhibits the Src family kinases, Abl kinase, c- kit and PDGFR. I hypothesised, combining Dasatinib with a cytotoxic agent dexamethasone; through direct antimyeloma effect, disruption of osteoclast cytoskeleton and adhesion of plasma cells to the bone marrow …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… with an anti-nitrotyrosine antibody revealed Src-family kinases (SFK) in the precipitated fraction. Moreover, SFK nitration was lost in cells depleted of caveolin-1. Given that SFK nitration is associated with enzyme activation, cells were pretreated with PP2 to inhibit SFK activity. We found …
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Quantitative mass spectrometry analysis of the early signaling dynamics of the epidermal growth factor receptor
… of the data suggests a connection with Src family kinases as contributors to EGFR signaling. Further exploration with targeted inhibition of Src and P13K create a quantitative mechanistic explanation for EGFR signaling. Lastly, inhibition of the network with clinically relevant tyrosines …
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Costimulatory function of CD44
… mediated by rac1, a small GTPase of the rho subfamily, and src-family kinases, two of which, fyn and lck, were found to be associated with CD44. By cross-linkage of CD44 these kinases were redistributed into so called lipid rafts. It is supposed that for T cell activation a relocation of the …
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