Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Src Family Kinase"”.
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The Role of Il-8-Mediated Src Family Kinase Activation In Tumor-Tumor and Tumor-Stromal Interactions In Metastasis of Prostate Cancer
… for PCa. Aberrant activation of protein tyrosine kinases, including Src Family Kinases (SFKs) contribute to metastasis through numerous functions, one of which leads to increased expression of cytokines, such as IL-8. However, the relationship between Src activity and IL-8 regulation is not …
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The Evolution of Platelet Responses to Collagen Under Conditions of Hemodynamic Flow
… through binding and directly activating the Src-family kinase Lyn. Chicken thrombocytes are potently activated by collagen but do not form 3-dimensional aggregates under arterial flow conditions, a profound contrast to platelet function. Despite selective expression of most platelet-specific …
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Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
Tks5 is a Src tyrosine kinase substrate and scaffolding protein for specialized cytoskeletal structures called podosomes/invadopodia. My doctoral thesis has focused on how Tks5 regulates the formation of these related structures and their impact on the invasive phenotype of cells. The podosomes of …
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Mechanisms of TRAF Signaling
… activated by tumor necrosis factor (TNF) superfamily proteins. Ligands of the TNF family engage TNF receptor (TNFR) family proteins, leading to a wide variety of cellular effects, these interactions are implicated in inflammation, immune regulation, bone homeostasis, and development. TNFR …
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Molecular Drivers of Bladder Cancer Motility
… transition (EMT) status. I studied the impact of Src inhibition on the motility of luminal and basal cell lines. My research demonstrates that while both luminal and basal models exhibit comparable cell signaling phenotypes following exposure to the Src Family Kinase (SFK) inhibitor AZD0530, only …
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Immunomodulatory effects of LL-37 in the epithelia
… suppressed by pretreatment with inhibitors of Src-family kinase signalling and NF-κB translocation. These data suggest that low concentrations of LL-37 may alter epithelial responses to microbes in vivo. Microarray analysis of keratinocyte transcriptional responses after LL-37 treatment suggest …
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Development of Tyrosine Kinase Peptide Biosensors and Methods for Detection
<p>New methods to monitor tyrosine kinase activity are critical for studying kinases in cell biology, drug discovery and the clinic. Peptide-based biosensors for detection of kinase activity utilitize a kinase specific artificial peptide substrate, which can report intercellular kinase activity …
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Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides
… of free CpG ODN results in the induction of the Src Family Kinase signalling cascade which mediates the migration of TLR9 from the ER to the late endosome, the uptake of free mCpGODN does not. However, it is suggested that encapsulation bypasses the methylation specific recognition of CpG ODN, …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… neurons to NMDA-induced Ca2+ influx through a Src family kinase (SFK)-dependent pathway. The effects of PbTx-2 on upregulating NMDAR function did not involve depolarization of the neurons as explained by the modest membrane potential change in FMP (FLIPR® membrane potential) blue fluorescence …
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Phenotypic screening and AI uncovers modulators of YAP and TAZ activity in glioblastoma
… The most promising compounds consisted of the Src family kinase inhibitors Dasatinib and eCF506 which showed dual reduction in YAP and TAZ nuclear translocation and subsequently reduction in cell proliferation through cell cycle arrest in both 2-dimensional and 3- dimensional spheroid assays. …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… activation was completely abolished by the pan-Src family kinase (SFK) inhibitor, PP2, or when Syk is inhibited. PP2 abolished phosphorylation of Syk and Phospholipase Cγ−2. Fucoidan-induced platelet activation had a lag phase, which is reminiscent of platelet activation by collagen and CLEC-2 …