Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 212 for “"Squamous cell carcinoma"”.
-
Radioresistance in oral squamous cell carcinoma
Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer accounting for approximately 6% of all cancers worldwide. However the distribution across the globe varies considerably. The majority of small tumours of the oral cavity and upper aerodigestive tract, in the absence of …
-
Genomic Drivers of Cutaneous Squamous Cell Carcinoma Development
… overall economic impact of $2 billion. Cutaneous Squamous Cell Carcinoma (cuSCC) comprises 15-20% of all skin cancers. cuSCC has the best-defined progression from a distinct precancerous lesion, the Actinic Keratosis (AK), to invasive cuSCC. Destructive therapies for AK treatment must be used …
-
Lymph node metastasis in auricular squamous cell carcinoma
Introduction Squamous cell carcinoma of the auricle has an unusually high rate of lymph node metastases when compared to similar tumours at other sites. The lymph nodes affected are close to the base of the skull and in the neck. Development of metastasis carries a poor prognosis and most patients …
-
Microrna Functions In Uv-Induced Cutaneous Squamous Cell Carcinoma
<p>Cutaneous squamous cell carcinoma (cuSCC) is the second most common skin cancer, for which long term UV exposure and chronic wounding are the dominant risk factors. Despite these clinically established connections, little is understood about the early molecular response of human skin to UV …
-
Analysis of driver gene mutations in oesophageal squamous cell carcinoma
… The two main subtypes are oesophageal adenocarcinoma (OAC) and oesophageal squamous cell carcinoma (OSCC). OAC is more common in North America and Europe, while OSCC predominantly occurs in Eastern Asia, Sub-Saharan Africa and Latin America. Over 80% of the OSCC cases and deaths worldwide …
-
Targeted Differentiation of Primary Head and Neck Squamous Cell Carcinoma Cells
Head and neck squamous cell carcinoma (HNSCC) is a malignant disease; it is the fourth most common cancer in Germany and the sixth most common cancer worldwide, with high fatality rates that have remained essentially unchanged for many years. Especially in the subtype that is negative for human …
-
Induced Cytotoxicity In Crebbp/Ep300Mut Head and Neck Squamous Cell Carcinoma
… <em>CREBBP</em>/<em>EP300</em>mut HEAD AND NECK SQUAMOUS CELL CARCINOMA</strong></p> <p>Thomaia Pamplin</p> <p>Advisor: Curtis Pickering, Ph.D.</p> <p>Background: Head and neck squamous cell carcinoma HNSCC is the most common malignancy in the head and neck. Most cases are found in advanced …
-
Tp53 As A Biomarker In Head and Neck Squamous Cell Carcinoma
… decisions for patients with head and neck squamous cell carcinoma (HNSCC). Several retrospective studies have evaluated TP53 in HNSCC, and results have suggested that specific mutations are associated with poor outcome. However, there exists heterogeneity among these studies in the site and …
-
Investigation of HPV16-related genomic alterations in cervical squamous cell carcinoma
… host genome on host gene expression in cervical squamous cell carcinoma (CSCC) tumors. The genomic analysis involved clinical and genomics data analysis using bioinformatics and statistical methods. The Cancer Genome Atlas Program (TCGA) resource was used to download Cervical Squamous Cell …
-
Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
… in murine epidermis and is associated with cell-cell adhesion turnover and migration. Introduction of active H-Ras(G12V) into the HaCaT human keratinocyte cell line resulted in upregulation of FYN mRNA (200-fold) and protein, but did not increase the expression of other SFKs. We identified …
-
Genetic analysis of squamous cell carcinoma of the head and neck
Head and neck squamous cell carcinoma (HNSCC) is the sixth commonest cancer worldwide with an increasing incidence in developing countries. Despite numerous advances in surgery, radiotherapy and chemotherapy over the past few decades the overall survival rate for patients with HNSCC has changed …
-
Transforming Growth Factor-Beta Signalling in Human Cutaneous Squamous Cell Carcinoma
… pathological driving events in human cutaneous squamous cell carcinoma (cSCC) in order to identify novel therapeutic targets. Already the second most common form of human non-melanoma skin cancer, the incidence of cSCC has continued to rise at epidemic proportions over the past two decades. …
-
Targeting head and neck squamous cell carcinoma through NQO1-mediated cytotoxicity
Head and neck squamous cell carcinomas (HNSCC) are a group of anatomically diverse cancers characterized by their resistance to traditional chemotherapy and radiotherapy modalities. Given that as diagnostic and therapeutic strategies in cancer treatment have seen great improvements over the last …
-
THREE DIMENSIONAL IN VITRO MODEL OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
Head and neck squamous cell carcinomas (HNSCC) are among the leading causes of cancer related deaths throughout the world. The survival rate for this type of cancer is extremely low and has not changed significantly in recent decades. There is an imperative need to study tumor progression in a …
-
Understanding the adhesome network in primary and metastatic cutaneous squamous cell carcinoma
Understanding how cancer cells survive, invade and migrate is of fundamental importance to the development of approaches to inhibit invasion and metastasis in patients. Proteins recruited at adhesion complexes, known as the adhesome, are involved in multiple mechanisms which control cancer cell …
-
Investigating the role of growth hormone receptor in oesophageal squamous-cell carcinoma.
Squamous-cell carcinoma of the oesophagus is a formidable disease which poses a significant health risk in developing countries where incidence is high and survival is low. Investigating the poorly understood mechanisms involved in oesophageal tumourigenesis may provide a platform to develop …
-
Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
Background, aim and objectives: Oesophageal squamous cell carcinoma (OSCC) is an endemic disease. Epidemiologic studies driven by investigation of Sammon in a region with one of the highest prevalence, linked a predisposition to develop OSCC to a high consumption of maize via reflux disease and …
Page 1 of 11