Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Spt5"”.
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Transcriptional elongation defects enhance upstream poly (A) site utilization and SPT5 affects mRNA degradation through its physical and functional interaction with CCR4 -NOT complex
… polymerase II subunit RPB2, elongation factor SPT5, or TFIIS. RPB2 and SPT5 defects also promoted the utilization of upstream poly (A) sites for genes that contain multiple 3 ' poly (A) signaling sequences, supporting a role for elongation in differential poly (A) site choice. Our data suggest …
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Transcription Coupled DNA Repair in Saccharomyces Cerevisiae: the Interplay of Facilitators and Repressors
… we mapped interactions between Spt5 and RNAP II in S. cerevisiae. Through its KOW4-5 domains, Spt5 extensively interacts with Rpb4/7. Spt5 also interacts with Rpb1 and Rpb2, two largest subunits of RNAP II, at the clamp, protrusion and wall domains. Deletion of Spt5 KOW4-5 …
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Warten auf die Transkription: Die humanen Elongationsfaktoren NELF und DSIF
… mit der NGN-Domäne der großen DSIF-Untereinheit hSpt5 näher zu charakterisieren. Die Struktur der RRM-Domäne von NELF E wurde mittels magnetischer Kernresonanz (NMR) bestimmt (PDB: 2BZ2) und besteht aus einem viersträngigen Faltblatt mit zwei alpha-Helices, die gegen eine Seite des Faltblattes …
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Regulation of Transcription Through RNA Polymerase II Promoter-Proximal Pausing
… mutate pausing complex subunits nelfe (NELF) and spt5 (DSIF) in mouse embryonic stem cells. Using genomic approaches such as global run-on sequencing, I validated that promoter-proximal pausing is perturbed in these mESCs. By utilizing monolayer and three-dimensional differentiation protocols, I …
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Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast
… complex which includes Rpb4 and the Spt4/Spt5 complex, which also suppress Rad26-independent TCR. The interactions among Pol II, Rad26 and the various TCR suppressors remain to be elucidated.