Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Sprague-Dawley Rat"”.
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Neural mechanisms promoting G-alpha-i2 protein dependent salt sensitive hypertension in the Sprague-Dawley rat
… the salt sensitivity of blood pressure, an exaggerated pressor response to elevated dietary sodium intake, is estimated to be present in approximately 50% of the hypertensive population and 25% of the normotensive population. This is a critical problem as the average American consumes roughly …
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The effect of dietary caloric restriction during pregnancy on maternal and fetal body composition in the obese Sprague Dawley rat
Obese, female Spraque-Dawley rats were assigned, on a weight basis, to one of three dietary treatments: ad lib, 15% caloric restriction, and 30% caloric restriction. All other nutrients were fed at levels to meet dietary requirements. Each treatment groups was further sub-divided into pregnant and …
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The effect of severe dietary caloric restriction during pregnancy on maternal and fetal body composition in the obese Sprague Dawley rat
Obese female Sprague Dawley Rats were randomly assigned, on a weight basis, to one of three dietary treatments: ad libitum, 30% caloric restriction, and 50% caloric restriction. All other nutrients were fed at levels to meet dietary requirements. Each treatment group was further divided into …
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The effect of non-weight-bearing exercise and protein intake during pregnancy on maternal and fetal zinc content in the Sprague-Dawley rat
… on maternal and fetal zinc status in the rat, one hundred and seventy-nine pregnant Sprague-Dawley rats were divided into four groups; sedentary-standard protein diet, sedentary-high protein diet, exercising-standard protein diet and exercising-high protein diet. The standard protein diet …
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The in vivo effects of copper, manganese and mercury mixtures on the heart, lung and brain and the coagulation system in the Sprague-Dawley rat model
… main sources of the increased heavy metal concentrations in the environment, including water. Drinking or the use of contaminated water can have harmful effects on human health contributing to cardiovascular, respiratory and neurodegenerative diseases. There is some data on the effects of metal …
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The potential role of interleukin-2 in impaired cell-mediated immunity of iron deficiency
… A (Con A)-stimulated spleen lymphocytes from rats and mice. Dietary iron deficiency induced in the weanling Sprague-Dawley rat and C57/B16 mouse were used as the nutritional models.
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Changes In The Testes Following Spinal Cord Injury and The Attenuating Effects of Licofelone
… cord injury causes within the testes using a Sprague Dawley rat model, including the elevation in eicosanoids, increased oxidative stress, chronically elevated unconjugated bile acids, altered immune cell populations, acutely decreased testosterone production, and acute elevations in …
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Chronic Ocular Hypertensive Model using Microbead Injection in Rats: Comparison of Polyurethane, Polymethylmethacrylate, and Polystyrene
… To establish and assess an ocular hypertensive rat model using intracameral injection with various microbeads of different sizes and materials. Methods: Chronic elevation of intraocular pressure (IOP) was induced by injection of various microbeads into the anterior chamber of Sprague-Dawley rat …
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Influence of chronic Helicobacter pylori infection on systemic and neuroinflammation and its impact on cognition
… has been growing in the field. Utilizing a Sprague-Dawley rat based model for chronic H. pylori infection, the role of chronic infection in the development of systemic and neuro-inflammation was evaluated. High sensitivity ELISA assays were utilized to determine the change in key …
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Transdermal delivery of heavy chain only antibody binding domains using hydrogel-forming microarray patches
… drugs in 2018 being antibody-based. However, rather than resting on their laurels, drug developers have continued to innovate. This has led to the development of ‘next generation’ biologics which have been designed to overcome the size and stability limitations associated with mAbs. This new …
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Brain Bioavailability Of Polyphenols: Implications For Delivery Of Brain Health Benefits
… considered potential risk factors for neurodegenerative disease on polyphenol bioavailability from a `Standardized Grape Polyphenol' (grape seed extract, Concord grape juice and resveratrol). Additionally, this thesis will provide novel evidence on plasma pharmacokinetics and regional brain …
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Mechanism of Action of Pentobarbital Induced Attenuation of Vascular Smooth Muscle Contraction
… Ca<sup>2+</sup> influx (ECI) by stimulating Sprague-Dawley rat tail artery rings with either 100 mM KC1, 50 uM phenylephrine (PE), or two different electrical field stimulation (EES) parameters: tetrodotoxin (TTX; 1 uM) sensitive, or perivascular nerve, (NEFS) stimulation (10 Hz, 0.3 ms, 50 …
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Effects of Burn Injury on Biological Ethanol and Ethyl Glucuronide Concentrations
… most frequently performed assay in forensic laboratories. Alcohol is routinely present in biological specimens from fatal residential fires and forensic toxicologists must interpret if these individuals are impaired by determination of their blood alcohol concentrations on post-incineration blood …
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The effect of hypoxia on ER-β expression in the lung and cultured pulmonary artery endothelial cells
… and pulmonary endothelial cells. In our Male Sprague-Dawley rat model, chronic hypoxia exposure (10% FiO2) resulted in a robust HPH phenotype associated with significant increases in ER- β but not ER-α protein in the lung via western blotting. More importantly, this hypoxia-induced ER-β …
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Dietary calcium: Effect of bioavailability and level of intake on bone growth, development and maintenance in the rat
… growth, development and maintenance using the rat as a model. The central hypotheses that were tested were: (I) dietary calcium provided from a low bioavailable source will compromise both bone quality and bone quantity in the young and old animal; and, (II) the higher the total level of …
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Building a Better Scar: Re-engineering Extracellular Matrix Structure in Dermal Scars
… Connexin Carboxy-Terminus 1 (αCT1), has demonstrated efficacy in improving long-term scar appearance in pre-clinical and clinical trials. However, current understanding of the mechanism-of-action by which αCT1 improves long-term scar appearance with early intervention treatment is not well …
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Effects of connexin modulators in animal models of retinal degeneration: delivery and treatment efficacy
Worldwide, age-related macular degeneration (AMD) is one of the most frequently ocurring diseases associated with blindness. Previous studies have provided evidence for the role of inflammation and oxidative stress in AMD progression. It has also been found that connexin hemichannels play a role in …
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Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.
… function, including differentiation and proliferation. The effect of TGF-¿1, 2, 3, and their manipulated forms in biological regulation of primary chondrocyte was investigated in this work. A novel method was developed to isolate and purify the primary chondrocytes from knee joint of neonate …
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