Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Spp1"”.
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… also revealed that secreted phosphoprotein 1 (SPP1) is as a required key mediator for TAMs neurogenic activities. TAM-derived SPP1 promote nerve growth by upregulating mTORC2/Rictor pathway in neural cells. Conclusions: Our findings revealed that in vitro generated hTAMs can be exploited as a …
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Decoding Disease Drivers Through Single-Cell Omics and Scalable Phenotypic Screens
… experiment with M.tb. I further report a SPP1+ macrophage population that is enhanced in TB diseased lungs through single-cell analysis. Moreover, I identified a prominent cross talk between SPP1+ macrophages and fibroblasts in TB diseased lung that mimics similar observations in cancer …
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Investigating the role of microglia in myelin development
… subset characterized by high expression of Spp1, Gpnmb, and Igf1 was found in white-matter regions in the early post natal brain but not at other time points. First, we developed a novel constitutive Cre mouse line, Fcrls-Cre, using the CRISPR-Cas9 system to target all subsets of microglia, …
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A CHARACTERIZATION OF THE BACTERIOPHAGE 41C AND ITS LYTIC CYCLE IN BACILLUS SUBTILIS 168
… proteins and in their plaque morphologies. Phage SPP1 produced a series of changes in the ultrastructure of the host cell which was identical to that of 41c-infected cells. In contrast, a dissimilar phage, SP82G, did not produce such changes in the host cells.</p>
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Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.
… of translational changes in Col1a1, Col1a2, and Spp1 highlighted effects of SMN deficiency on translational regulation, in the absence of transcriptional alterations. Validation studies in both mice and SMA patient-derived fibroblasts further underscored the potential of translational …
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Chemical genetic manipulation of interferon regulatory factor 1 (IRF-1) using synthetic biology
… the up-regulation of secreted phosphoprotein-1 (SPP1) and SH3 and PX domains-2A (SH3PXD2A) which are matricellular protein produced by cancer cells playing a role in cellular adhesion, invasion, tumour growth progression and metastasis. Thus, we proposed a new biological role of IRF-1 in cellular …
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Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration
… and osteogenic markers (COL10A1, ALPL, IBSP, and SPP1) exclusively in hBMSCs/SSCs attached to HyA-FMBs. Transcriptomic measurements confirmed increased BMP signalling in stable hyaline-like cartilage produced by ectopic transplantation of hBMSCs/SSCs attached to HyA-FMBs. Using this knowledge, I …
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …