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Showing 1 to 18 of 18 for “"Sporozoites"”.
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Immunization with sporozoites: an experimental study of Plasmodium berghei malaria
Contains fulltext : mmubn000001_249901137.pdf (Publisher’s version ) (Open Access)
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Cryptosporidium Parvum Microbial Adhesion: Interactions Between Sporozoites and Host Cells
… of attachment and invasion of C. parvum sporozoites to host cells, our goal was to elucidate the mechanism of sporozoite recognition of receptors on the host cell membrane. Knowledge of these mechanisms may allow for novel therapeutic strategies for cryptosporidiosis. An in vitro cell …
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A Cytological Study of the Sporozoites of Eimeria Caviae, a Coccidian Parasite of the Domestic Guinea Pig, Cavia Porcellus
… and cytological characteristics of the sporozoites of Eimeria caviae, Sheather (1924), a coccidian parasite of guinea pigs. Observations concerning the prepatent and patent periods, the symptomatology and pathology, and the morphological features of the oocysts of this species are also …
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Development and Evaluation of an Isospora Suis Sporozoite Neutralizing Antibody Assay in Swine Testicular Cells
… by determining both the amount of intracellular sporozoites by immunofluorescence and the cytopathic effect in ST cells. A monoclonal antibody against the apical complex of I. suis sporozoites inhibited the infection of sporozoites in vitro. Hyperimmune sera produced in goats and guinea pigs …
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Mathematical modelling of transmission and control of malaria
Malaria starts with plasmodium sporozoites infection of the host liver, where development into blood stage parasites occurs. A number of deterministic models are developed in this thesis. The release of modified mosquitoes aims to displace gradually the wild (natural) mosquito from the habitat. We …
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Investigating the role of the Apicoplast in Plasmodium falciparum Gametocyte Stages
… in the midgut, leading to the production of sporozoites that will migrate to the salivary gland. The sporozoites will be injected to another human host during the next blood meal consequently, transmitting malaria. Due to decreased drug susceptibility of mature gametocytes, more investigation …
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Evaluation of hops essential oil cytotoxicity and anti-cryptosporidium activity
… HCT-8 cells were infected with C. parvum sporozoites (1x104 sporozoites/mL) and immediately treated with bioactives dissolved in DMSO followed by incubation for 48 h (37℃ and 5% CO2); and (2) confluent HCT-8 cells were infected with C. parvum sporozoites, and 2 h later were treated with …
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Lifecycle Progression And The Sexual Development Of The Apicomplexan Parasite Cryptosporidium Parvum
… meiotic spores called oocysts release invasive sporozoites in gut. Sporozoites infect intestinal enterocytes where parasites multiply asexually followed by sexual differentiation. Parasites have sex and then undergo sporulation in the host to produce mature oocysts. Oocysts re-infect the host or …
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Towards functional assignment of Plasmodium membrane transport proteins: an experimental genetics study on four diverse proteins
… cycle. Strikingly, in two stages, schizonts and sporozoites, FT2 displays a dual localisation. Analysis of FT2-deficient parasites revealed a severe sporulation defect in the vector; the vast majority of ft2‚Äì oocysts form large intracellular vesicles which displace the cytoplasm. Accordingly, …
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Towards functional assignment of Plasmodium membrane transport proteins: an experimental genetics study on four diverse proteins
… cycle. Strikingly, in two stages, schizonts and sporozoites, FT2 displays a dual localisation. Analysis of FT2-deficient parasites revealed a severe sporulation defect in the vector; the vast majority of ft2‚Äì oocysts form large intracellular vesicles which displace the cytoplasm. Accordingly, …
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Effect of Metabolic Enzymes on Amylopectin Content and Infectivity of Cryptosporidium parvum
… infectivity of Cryptosporidium parvum oocysts/sporozoites in both fresh oocysts and stored oocysts. In addition, glycolytic enzymes and substrates: glucose, glucose-1-phosphate, and glycogen synthase were investigated to determine if they can be used to increase amylopectin stores and thus …
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Cultivation of Eimeria Dispersa in Bobwhite Quail Embryos
… in Tyrode's solution. Between 1,000 and 44,000 sporozoites were inoculated into the allantoic cavity of 10-to 12-day-old embryos with the aid of a tuberculin syringe. The allantoic fluid and chorioallantoic membranes were removed from inoculated eggs at 12-hour intervals from 1/2 through 10 days …
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Fatty Acid-Mediated Inhibition of Host Cell Invasion by Cryptosporidium Parvum
… inhibited the invasion of host enterocytes by sporozoites in vitro by blocking microneme secretion. These results indicate a potential chemotherapeutic utility for a subset of long chain unsaturated free fatty acids in the treatment of cryptosporidiosis.
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The ultrastructural morphology of Eimeria tenella exhibits striking natural variation and undergoes significant changes during the first few hours of infection
… seen in both freshly hatched and post-invasion sporozoites, suggesting that genetic factors are involved. Following analysis of structures within the conoid, my data suggests that secretory organelle protein release occurs through intra-conoidal transport, docking and fusion.
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Host-Pathogen Interactions at the Intestinal Epithelial Barrier
… infected with E. vermiformis or E. falciformis sporozoites. These completed several rounds of asexual replication but did not proceed to the final gametogony. Despite the need for the development of sensitive techniques applicable to three-dimensional cell culture models, these results indicate …
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Studies on cathepsin B of Eimeria tenella and pyroglutamyl peptidase of Leishmania major
… B may play roles in both cell invasion by sporozoites and the formation of the protective wall of the oocyst. A single copy gene encoding a PPI was identified in the genome database of L. major. Active recombinant enzyme was successfully produced in E. coli and its biochemical properties …
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A Multi-level Model for a Vector-Borne Organ to Tissue life Cycle Dynamics
… by the Anopheles mosquito, which inoculates sporozoites into the human host during a blood meal. The population dynamics of malaria are well-known for their complexity, stemming not only from the parasite’s lifecycle, which involves two hosts (humans and mosquitoes)but also from the intricate …
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Mechanical manipulation and visualization of single biomolecules using fluorescence spectroscopy
… protein, this explains the high motility of the sporozoites through vasculature with varying diameters. Moreover, as the repeat peptides are highly sensitive to forces up to ~ 28 pN, they can be used for engineering cellular tension sensors, for reporting force values within a wide range between …