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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 17 of 17 for “"Spontaneous Mutation"”.

  1. Spontaneous mutation in Escherichia coli under aerobic and anaerobic conditions

    Hashemi, Parivash

    sjsu Repository record

  2. Elucidation of Theg Gene Role in Spermatogenesis and Characterisation of a Novel Spontaneous Mutation Named “nax” in Mouse

    Mannan, Ashraf-ul2012

    … von knockout Mäusen, wurde eine spontane Mutation mit der Bezeichnung nax in den ES-Zellen vorgenommen. Diese Mutation war autosomal-rezessiv. Die nax Mäuse zeigen ein komplettes Ausfallen der Haare nach der Geburt und zeigen eine Wachstumsretardierung im Laufe der Entwicklung. Ein …

    goettingen Repository record

  3. An experimental investigation into the mechanisms of bacterial evolution

    Wan, ZhenmaoThe Graduate School and University Center of The City University of New York2001

    … evolution &mdash; horizontal gene transfer and spontaneous mutation, in the bacterium <em>Escherichia coli</em> through novel experimental assays and mathematical simulations. First, I will develop a growth assay utilizing the quantitative polymerase chain reaction (qPCR) to provide real-time …

    cuny-grad Repository record

  4. Utilization of TMV-TEMPO as an in Vivo MRI Sensor of ROS Production in Liver Inflammation and as a DNP Agent

    Lumata, Jenica Laporca 1994-2023

    … identification and physical characterization of spontaneous mutation of TMV in a laboratory environment. Chapter 3 shows the successful utility of reduced TMV- TEMPO as an in vivo T2 -weighted MRI sensor of ROS in lipopolysaccharide (LPS)-induced liver inflammation in Balb/c mice. Chapter 4 …

    tdl Repository record

  5. The impact of a single nucleotide polymorphism in fusA1 on biofilm formation and virulence in Pseudomonas aeruginosa

    Maunders, Eve AlexandraUniversity of Cambridge2018

    … fusA1, encoding elongation factor G (EF-G). The mutation introduced minor structural changes to the protein which were likely to have functional repercussions in its involvement in protein synthesis. Phenotypic analysis revealed that the mutation conferred changes in both resistance and …

    cambridge Repository record

  6. Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-

    Sears, Sheila Marie Shahidzadeh

    … mice — mice that are null for Sxc- because of a spontaneous mutation in exon 12 of SLC7A11 — we uncovered a sex-independent alteration in neuronal excitability. Specifically, we found that both female and male SLC7A11sut/sut mice had lower convulsive seizure thresholds than their wild-type …

    syracuse-diss Repository record

  7. Discovery of a novel meiotic E3 ubiquitin ligase by characterisation of the barley desynaptic mutant <i>DES12.W</i>

    Mittmann, Sybille UrsulaUniversity of Dundee2017

    … and characterised. The des12.w allele is a spontaneous mutation, causing severe semi-sterility. It is characterised by an abnormal synaptonemal complex during prophase I leading to improper chromosome segregation due to ‘sticky’ chromosomes causing chromosomal bridges and fragments. …

    dundee Repository record

  8. Isolation of antimutator yeast strains: an exploration of DNA replication fidelity

    Williams, Lindsey Nicole2013

    … manifested as a 10- to 100-fold increase in spontaneous mutation rate. Haploid yeast strains with combined defects in Pol proofreading and MMR initially divide, but succumb to error-induced extinction and fail to form viable colonies. We exploited error-induced extinction to isolate …

    washington Repository record

  9. Biochemistry and functional analysis of exopolysaccharide production in Lactobacillus johnsonii

    Dertli, EnesSchool of Biological Sciences2013

    … L. johnsonii harbours an eps gene cluster and a spontaneous mutation in the phosphoregulatory system of this cluster resulted in a colony switch from a rough morphology to a smooth one; similarly deletion of the epsE gene, that encodes the putative priming glycosyltransferase of the EPS …

    east-anglia Repository record

  10. FROM DISEASE TO THE GENE - Identification of arthritis-regulating loci in rats

    Rintisch, CarolaDepartment of Experimental Medical Science, Lund Univeristy2009

    … second study is based on the observation that a spontaneous mutation in our DA rat colony results in decreased arthritis susceptibility in the DA rats. We subsequently isolated the mutation in a new substrain of DA rats, called DACP, and using genetic linkage analysis we located the mutation and …

    lund Repository record

  11. Investigating the role of eEF1A2 in motor neuron degeneration

    Griffiths, Lowri AnnThe University of Edinburgh2011

    … cell types such as motor neurons and muscle. A spontaneous mutation in eEF1A2 results in the wasted mouse phenotype which shows similar characteristics in the mouse to those seen in human motor neuron degeneration. This mutation has been shown to be a 15.8kb deletion resulting in the complete …

    edinburgh Repository record

  12. Micro-evolution of foot-and-mouth disease virus

    Cottam, Eleanor MyfanwyUniversity of Glasgow2008

    … types, and farm sizes), and the manner in which mutations become fixed within the consensus sequence (i.e. upon replication and selection, and transmission through a ‘bottleneck’). This encouraged an analysis of the minimum mutant frequency of Pan Asia O FMDV from a single lesion sampled from …

    glasgow Repository record

  13. The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis

    Dagpo, Tenzin2015

    … are unclear. Fat aussie (foz/foz) mice have a spontaneous mutation in the Alms 1 gene, causing defective appetite regulation, overfeeding and obesity. Interestingly, after 24 weeks of age on high fat (HF) diet, female Balb/c foz/foz mice develop healthy obesity; whereas NOD.B10 foz/foz mice on …

    aus-cath Repository record

  14. The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis

    Dagpo, Tenzin2015

    … are unclear. Fat aussie (foz/foz) mice have a spontaneous mutation in the Alms 1 gene, causing defective appetite regulation, overfeeding and obesity. Interestingly, after 24 weeks of age on high fat (HF) diet, female Balb/c foz/foz mice develop healthy obesity; whereas NOD.B10 foz/foz mice on …

    anu Repository record

  15. Molecular Genetic Analysis of Tumor Cells and Developmenet of RNA Interferance Therpy in Neurofibromatosis Type1(NF1)

    정, 현정2011

    … of NF1 patients representing de novo germline mutations, implying an extremely high spontaneous mutation rate of the NF1 gene. The two major life-threatening complications of NF1 are hypertension and a significantly higher rate of malignancy, which contribute to a shorter life expectancy than …

    ajou Repository record

  16. STUDY OF COVALENT AND NON COVALENT INTERACTIONS OF BIOPOLYMER BY MASS SPECTROMETRY

    F. RICCARDI SIRTORIUniversità degli Studi di Milano2010

    … DNA that are responsible for most of the common mutations leading to formation of tumors in humans. TG mismatches are particularly abundant in cells lacking mismatch repair mechanism (MMR). MMR is involved in the correction of DNA polymerase errors that escape proofreading activity. MMR …

    milano Repository record

  17. Calcium Channel Dysfunction in Huntington’s Disease

    Cherry, Sheree D.2016

    … disease that is caused by an expansion mutation in the huntingtin protein that lengthens a naturally occurring trinucleotide CAG repeat in exon 1 resulting in striatal degeneration. The mechanism by which striatal neurons undergo selective degeneration is not fully understood, although …

    tenn-hsc Repository record