Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Splenomegaly"”.
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Use of cell wall-hydrolytic enzymes in studies of the reticuloendothelial-stimulatory properties of Propionibacterium acnes
… Patella vulgata, were able to abrogate the splenomegaly-inducing activity of vaccines. Inactivation of vaccine occurred without lysis of bacteria, only at high concentrations of lysozyme, and was reversed by subsequent treatment with trypsin, suggesting that lysozyme inactivation was due to …
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A study of the immune response in murine experimental malaria, with special reference to the effects of South African medicinal plants, artesunate and chloroquine
… chabaudi chabaudi AS infection results in splenomegaly, and activation of the immune system. Resistant C57BL/6 mice, which eliminate the parasites and survive the infection, developed marked splenomegaly. Susceptible A/J mice develop minimal splenomegaly. In this work it has been shown that …
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ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΚΑΡΔΙΟΛΙΠΙΝΗΣ: ΚΛΙΝΙΚΗ ΣΗΜΑΣΙΑ
… OF IMMUNOLOGICAL HYPERREACTIVITY INCLUDING SPLENOMEGALY AND/OR DIFFUSE LYMPHADENOPATHY (P<0.001) ANTI- NUCLEAR ANTIBODIES (P<0.01), ANTIBODIES TO RO(SSA) (P<0.01), TO U1NRNP (P<0.005)AND TO DOUBLE-STRANDED DNA (P<0.005). THERE WAS NO CORRELATION WITH THE PRESENCE OF THROMBOTIC EVENTS, …
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Clinical, Diagnostic, Therapeutic and Prognostic Aspects of Autoimmune Liver Diseases /// Клинико-диагностични, терапевтични и прогностични аспекти на автоимунните чернодробни болести
… overlap синдром, Newcastle Varices in PBC - Splenomegaly score за прогнозиране наличието на варици при пациенти с ПБХ. Потвърдена е ролята на Budesonide за постигане и поддържане на ремисия при пациентите с АИХ. Оценен е биохимичният отговор и дългосрочна прогноза на пациентите с ПБХ. …
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Implementation of the JAK2V617F mutation analysis in the pathway of suspected myeloproliferative neoplasms in Groote Schuur Hospital
… OR leukocytosis and/or thrombocytosis and/or splenomegaly; OR patients with thrombosis without cytoses. Patients were investigated for MPN and managed in the haematology clinic of Groote Schuur Hospital. We studied the association of clinical and laboratory variables with clonal vs non-clonal …
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Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
… prolonged overall survival, and ameliorated splenomegaly, but not affected the lung metastasis. Moreover, the therapeutic effect of Akt inhibition was potentiated in combination with carfilzomib. In conclusion, targeting Akt signaling may represent an attractive potential therapeutic target …
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Determining the impact of Heligmosomoides polygyrus infection on the development of colitis
… restored epithelial integrity and abrogated splenomegaly. This work uncovers an unexpected and novel role for live helminth infection in exacerbating IBD and suggests that helminth-induced dysbiosis of the microbiota may drive disease. These studies reveal restoration of the microbiota …
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Biochemical and genetic analysis of the adaptor protein SH3P7 : insights from a newly generated knockout mouse
… and sh3p7+/- mice of this strain develop splenomegaly and a progressive and ultimately fatal disease at 3-4 months of age. Initial FACS-analysis of the cellular composition of the spleen show drastic reduction of T1 B cells which might be interpreted as defect in B cell development or …
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Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
… model. ADRB2-/- animals presented with splenomegaly and greater weight loss in infection and colitis, compared to ADRB2 sufficient animals, respectively. ADRB2-/- animals rapidly succumbed to a sub-lethal LPS challenge, which correlated with elevated serum levels of TNFα and reduced …
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CD4+ T cells in the pathogenesis of visceral leishmaniasis
… with high parasite burdens in visceral organs, splenomegaly, cachexia, pancytopenia and will progress to death if not treated. Control of Leishmania infection is dependent on Th1 (IFNγ producing) CD4+ T cells, which activate macrophages to produce nitric oxide and kill the intracellular …
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PI3Kδ in B cell Homeostasis and Transformation
… immune cell populations in young mice but led to splenomegaly in old mice. Furthermore, mass spectrometry was performed to assess the steroid secreting potential of B cells in response to PI3Kδ. In summary, this thesis highlights PI3Kδ-driven changes in B cell populations in the context of health …
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Feature detection in ultrasound images for computer aided diagnosis of Hodgkin's Lymphoma
… of clinical interest: splenic enlargement (splenomegaly), splenic lesions, splenic microabscesses, abdominal lymph node enlargement, ascites, and effusions (pleural and pericardial). The developed protocol provided a novel guideline to identify an abnormality from the available ultrasound …
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Characterization of Avirulent Turkey Hemorrhagic Enteritis Virus: A Study of the Molecular Basis for Variation in Virulence and the Occurrence of Persistent Infection
… Enteritis Virus (THEV) resulting in depression, splenomegaly, intestinal hemorrhage, immunosuppression, and mortality. Avirulent strains that do not produce intestinal lesions and mortality are used in live-virus vaccines that protect turkeys from virulent field challenge. The cause for the …
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Molecular and functional studies of ABL1 and FGFR1 fusion oncogenes in myeloproliferative neoplasms
… in transplanted mice, with eosinophilia, splenomegaly, and accumulation of blasts. The established in-vivo model of EMS should constitute a valuable tool for obtaining further insights into FGFR1 fusion gene mediated leukemogenesis and for the development and evaluation of new treatment …
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… autoimmunity with hallmarks of SLE including splenomegaly, presence of autoreactive antibodies against nuclear antigens and glomerulonephritis. Characterisation of innate immune populations in ABIN1[D485N] mice showed that these mice have a massive increase of Ly6C-ve patrolling monocytes. …
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Inhibition of Heat Shock Protein 90 Reduces Inflammatory Signal Transduction in Murine J774 Macrophage Cells and Lessens Disease in Autoimmune MRL/lpr Mice: What in vitro, in vivo, and in silico Models Reveal
… found to have reduced proteinuria and reduced splenomegaly. Flow cytometric analysis of splenocytes showed that 17-DMAG decreased double negative T (DNT) cells. Renal expression of HSP90 was also measured and found to be increased in MRL/lpr mice that did not receive 17-DMAG. The mechanistic …
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
… growth rate as well as metastatic disease and splenomegaly when inoculated with 4T1 breast cancer cells. Such increased tumorigenicity was associated with a significant decrease of IFNg production in 4T1 tumor-bearing Tyk2 deficient mice T cells compared with wild type (WT) mice. We …
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In Vivo Functional Significance of Ccat2 Long Non-Coding Rna In Myelodysplastic Syndrome
… induction of widespread pancytopenias with splenomegaly and hepatomegaly. CCAT2(G/T) BM biopsies displayed severe myeloid and erythroid hyperplasia with enhanced proliferation and excessive apoptosis, along with extramedullary hematopoiesis in spleen and liver. Percentage of HSPCs was …
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Abdominal Tuberculosis is common and under-diagnosed in HIV positive Adults in Zambia
… masses based on ultrasound, hepatomegaly or splenomegaly, pancreatic enlargement, or unexplained focal or generalised pain/tenderness persisting over 7 days. The exclusion criteria included: HIV negative, solely pelvic and renal abnormalities, on antituberculous treatment for more than 1 week …
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