Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Spleen tyrosine kinase"”.
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The Contribution of Spleen Tyrosine Kinase to the Pathobiology of Alzheimer’s Disease
… elusive. We investigated the contribution of the spleen tyrosine kinase (SYK) in AD pathobiology. Syk is wellknown for its involvement in B-cell receptor (BCR) signaling but our previous data have demonstrated that SYK is also involved in tau yperphosphorylation and A-beta production, therefore …
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Investigation of the potential of Spleen Tyrosine Kinase (SYK) as a target for host-directed therapy during mycobacterial infection in macrophages
… for limiting tissue pathology caused by Mtb. Spleen tyrosine kinase (SYK) plays an important role in innate immune signalling. It is expressed on innate immune cells such as macrophages. Macrophages play a critical role in thepathophysiology of TB. They are the first responders to Mtb …
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N-terminomics/proteomics investigation of Calpain-2 substrates
… We have shown that calpain-2 has novel targets spleen tyrosine kinase (SYK) in THP-1 cells when activated by calcium and may play a role in regulating kinase.
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UNIQUE ALLOSTERIC MECHANISM REGULATING PROTEIN-PROTEIN INTERACTION THROUGH PHOSPHORYLATION: A CASE STUDY OF THE CONFORMATIONAL CHANGES IN THE SYK TANDEM SH2 PROTEIN
Spleen tYrosine Kinase (Syk) is one of the crucial signaling proteins involved in the development of immune cells and the initiation of inflammatory responses. Syk is a 72-kDa kinase comprising three folded domains: two SH2 domains and a catalytic domain. The tandem SH2 domains connected by linker …
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Biophysical studies of the allosteric regulatory mechanism of Syk tandem SH2 domains interacting with immunoreceptor tyrosine-based activation motifs
<p>The non-receptor spleen tyrosine kinase (Syk) is an important player in signal transduction from immunoreceptors to various downstream targets. It is widely expressed in both haematopoietic and epithelial cells. Syk disorder is closely related with many inflammatory and autoimmune diseases, as …
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The SYK tyrosine kinase suppresses autolysosome biogenesis via activation of mTORC1 in pancreatic cancer cell lines
Spleen tyrosine kinase (SYK) regulates mitogenic signaling, inflammatory responses and cell fate in a number of diverse cell types. KRAS is a proto-oncogene that controls cell growth and proliferation through several mitogenic pathways. In pancreatic cancer, KRAS is frequently mutated, resulting in …
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Functions of Phosphatidylinositol 4-Phosphate 5 Kinases in Actin Cytoskeletal Regulation During Phagocytosis
… by type I phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) through the phosphorylation on the D-5 position of the inositol ring of phatidylinositol 4-phosphate [PI(4)P]. Mammals have three PIP5K isoforms named a, b, and g (human isoform designation) which have a highly conserved central …
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Regulation of Syk activity in GPVI-mediated platelet activation
… A major signaling protein in GPVI signaling is Spleen tyrosine kinase (Syk). It undergoes phosphorylation and activation following GPVI stimulation. Syk's central role in this physiological process suggests regulation of its activity is required to maintain the platelets response to collagen …
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Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… platelet clot or thrombus formation. The protein kinase family of enzymes mediates a significant number of these intracellular signaling events that culminate in platelet activation. These enzymes can be broadly classified into two classes- tyrosine kinases and serine/threonine kinases. Syk …
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Studying Microglia-Mediated Neurodegeneration Using Cocultures
… assays identified potential roles for urokinase (uPA) and spleen tyrosine kinase (SYK) in microglia-mediated neurodegeneration. uPA is an extracellular protease that may also regulate migration, inflammation and proliferation in association with its receptor uPAR. SYK signals downstream of …
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STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE
… that defects in the functions of the protein-tyrosine kinase SYK, which is important both for macrophage activation and phagocytosis, might underlie much of this pathology. Recent evidence from our lab indicates that SYK can associate with stress granules, ribonucleoprotein particles that form …
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The Regulation of Phosphorylation Events in Platelets
… downstream of all these separate pathways, kinases become activated and play a crucial role in phosphorylating their substrates to elicit critical cellular responses. Previously published studies have established the importance for myosin kinase in its role for phosphorylating the myosin …
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Inflammasome signalling during Salmonella Typhimurium infection
… and decreases IL-1β processing by inhibiting spleen tyrosine kinase (SYK)-mediated NLRP3 activation and represses caspase-8 activity in the inflammasome. CARD9 expression is suppressed in the course of S. Typhimurium infection which may act as a mechanism to increase IL-1β production during …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… reduced phosphorylation of the protein tyrosine kinase (PTK) spleen tyrosine kinase (Syk) and reduced intracellular Ca2+ release in SLE B cells [14]. Further studies reported reduced responsiveness of SLE B cells to TLR9 stimulation which recognizes nuclear antigens and is considered key …