Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Spironolactone"”.
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The effect of spironolactone on exercise capacity in functionally impaired older people without heart failure
… of the renin-angiotensin-aldosterone system with spironolactone would improve physical function in older people without heart failure. In a double-blind, randomised controlled clinical trial 120 participants, aged >65 years with functional impairment were randomized to receive 25mg spironolactone …
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Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
… late-stage diabetes. MR inhibition with spironolactone treatment improved coronary endothelium-dependent vasodilation in OLETF rats. Further, RNA sequencing of aortas from Spironolactone-treated OLETF rats revealed 157 differentially expressed genes predicting MR involvement in …
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Corticosteroid hormone action in the cardiovascular system
… in essential hypertension and the effect of spironolactone (Spiro) upon their secretion and metabolism in patients with chronic kidney disease. We have shown that mineralocorticoids but not glucocorticoids are involved in elevated blood pressure in essential hypertension and that Spiro …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… increased VCAM-1 expression in MAECs. Spironolactone pre-treatment blocked the effect of aldosterone, suggesting an MR-mediated mechanism. Corticosterone alone had no effect on VCAM-1 expression. However, inhibition of 11β-HSD2 by pre-treatment with glycyrrhetinic acid allowed …
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Chronotropic Incompetence in Patients with Heart Failure and a Preserved Ejection Fraction: Prevalence and Impact on Exercise Tolerance
… intervention, as well as an enalapril and a spironolactone intervention on the prevalence of CI in HFrEF patients. METHODS: Prevalence and impact of CI on exercise tolerance was evaluated in 207 HFpEF subjects from three previously conducted studies (PARIS II, PIE I, PIE II). Symptom limited …
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The glutamate hypothesis of depression: the effect of stress and glucocorticoids on glutamate synapse and the action of antidepressants
… with RU486, selective GR antagonist, and spironolactone, selective MR antagonist, prevented the CORT-induced increase of RRP. Contrary to acute stress, CORT by itself did not promote vesicle fusion, since CORT application in vitro did not increase glutamate release evoked by depolarization …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
… or high salt diet in presence or absence of spironolactone for 10 days. Besides for experiments with metabolic cages the rats were characterized by tail-cuff measurements of blood pressure. Kininogens, bradykinin (BK), kallidin-like peptide (KLP), ET-1, deoxycorticosterone (DOC), …
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Pharmacogenetics of resistant hypertension: evaluating the role of genetic variation in ABCB1, ADBR1, CES1, CYP3A4, CYP3A5, NEDD4L, NOS3, NR3C2 and SCNN1B among South African hypertensive patient
… drugs such as amlodipine, enalapril or spironolactone, increasing their exposure and efficacy. NOS3 rs3918188A allele may affect NOS3 gene expression, or its effect may be due to variants in linkage disequilibrium with it, leading to increased efficacy of antihypertensives drugs such as …