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Showing 1 to 4 of 4 for “"Spiroligomers"”.
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Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors
This work presents the application of spiroligomers as inhibitors of protein-protein interactions. After the discovery of an acyl-transfer coupling reaction by Dr. Zachary Brown, a previous graduate student of Schafmeister group, the synthesis of highly functionalized spiroligomers that mimic the …
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Design, synthesis, and structural elucidation of spiroligomers for targeted molecular recognition
Spiroligomers are rigid, shape-programmable, sequence-defined molecular scaffolds assembled from stereochemically pure bis-amino acid building blocks. By controlling backbone stereochemistry, spiroligomers enable precise and predictable three-dimensional presentation of side chains, offering a …
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CONSTRUCTING NANOSTRUCTURES WITH ATOMIC PRECISION: THE SYNTHESIS OF SPIROLIGOMER-BASED MACROCYCLES
… between organic molecules and small proteins. “Spiroligomers” (formerly known as “bis-peptides”) are a class of molecules produced by the assembly of “bis-amino acids”, molecules containing two amino acid regions on a single cyclic core. Each bis-amino acid is connected through pairs of amide …
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NATURAL PRODUCT AND BUILDING BLOCK SYNTHESIS: CAROLACTON-INSPIRED ANALOGS, THE ANTITUMOR THERAPEUTIC FRAX-1036, AND THE CONSTRUCTION OF ATOMICALLY PRECISE MEMBRANES FROM SPIROLIGOMERS
Ever since traditional medicine developed thousands of years ago, humans have looked to natural substances as remedies for maladies. Today, many isolation and natural product chemists have begun revisiting ancient folk medicines in an attempt to isolate the compound(s) responsible for effective …