Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Spiroligomer"”.
-
CONSTRUCTING NANOSTRUCTURES WITH ATOMIC PRECISION: THE SYNTHESIS OF SPIROLIGOMER-BASED MACROCYCLES
… of a synthetic strategy to produce various spiroligomer-based macrocycles that bridge the gap between organic molecules and small proteins. “Spiroligomers” (formerly known as “bis-peptides”) are a class of molecules produced by the assembly of “bis-amino acids”, molecules containing two …
-
Design, synthesis, and structural elucidation of spiroligomers for targeted molecular recognition
Spiroligomers are rigid, shape-programmable, sequence-defined molecular scaffolds assembled from stereochemically pure bis-amino acid building blocks. By controlling backbone stereochemistry, spiroligomers enable precise and predictable three-dimensional presentation of side chains, offering a …
-
Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors
This work presents the application of spiroligomers as inhibitors of protein-protein interactions. After the discovery of an acyl-transfer coupling reaction by Dr. Zachary Brown, a previous graduate student of Schafmeister group, the synthesis of highly functionalized spiroligomers that mimic the …
-
NATURAL PRODUCT AND BUILDING BLOCK SYNTHESIS: CAROLACTON-INSPIRED ANALOGS, THE ANTITUMOR THERAPEUTIC FRAX-1036, AND THE CONSTRUCTION OF ATOMICALLY PRECISE MEMBRANES FROM SPIROLIGOMERS
… precise membranes, was conducted using spiroligomer building blocks and unnatural amino acids to furnish a triangle-shaped macrocycle via solution and solid phase techniques. This dissertation highlights the usefulness of the techniques of diverted total synthesis and building block …