Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Spirocycles"”.
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Novel titanium carbenoid reagents: diversity orientated synthesis of indoles and spirocycles
A new synthetic strategy for the preparation of a 96-member library of 2,5-disubstituted indoles involving traceless cleavage from resin is presented. A boronate-bearing titanium alkylidene was prepared and used to convert 8 resin-bound esters into immobilised enol ethers. Cleavage from resin in …
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SYNTHESIS OF ALL-CARBON SPIROCYCLES BY INTRAMOLECULAR IRON-MEDIATED DIENE/OLEFIN CYCLOCOUPLING
Previous work done in the Pearson laboratory led to the success of an intramolecular double cyclization reaction using cyclohexadiene-Fe(CO)3 with pendant conjugated dienes that are attached via an amide group. Then a novel method was found for the construction of an angular triquinane skeleton by …
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Asymmetric synthesis of medium-sized carbocycles spirocycles and oxabicycles via ring closing metathesis sufoximine substituted trienes and dihydropyran derivates
The synthesis of substituted chiral medium-sized carbocycles is an important goal of organic synthesis. Ring-closing metathesis of acyclic dienes is a very effective method for the synthesis of medium-sized carbocycles. In this project, sulfoximine-substituted trienes were proven to be excellent …
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Fragment synthesis: pharmacophore and diversity oriented approaches
… chemistry was also applied to synthesising spirocycles from rings with exocyclic double bonds. These being readily installed from Wittig chemistry, this allowed utilisation of starting materials which contained a cyclic ketone. Of these azetidinone was a good candidate due to the fact it was …
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Synthetic studies on Canangone and beta-Chamigrene
… the quaternary stereocenter containing spirocycles, (+)-Canangone and beta-Chamigrene. Michael acceptor was prepared in three steps. The Robinson annulation of enamino lactone and Michael acceptor followed by hydrolysis provided the spirolactone. Subsequent deprotection, Luche reduction …
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ORGANOCATALYTIC HALOFUNCTIONALIZATION OF OLEFINS
… Next, an asymmetric synthesis of heterospirocycles through a double-halocyclization strategy which enabled access to a class of chiral novel spirocycles is reported. In a separate study, the intramolecular chloroamidation of olefinic substrates using diphenyl selenide as the catalyst is …
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Radical methods for the synthesis of aliphatic amines
… light-mediated direct synthesis of N-heterospirocycles is reported. A photocatalyst was employed to reduce an aliphatic iminium ion to the corresponding -amino radical, which was cyclized to afford polar, heteroatom-rich spirocycles. The reaction tolerated a range of polar functional groups …
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Applying Trichloroacetimidates to the Synthesis of Benzylic Trichloroacetamides & Functionalized Indoles
… is envisioned to be applied in the synthesis of spirocycles from bis-trichloroacetimidates, which are three-dimensional in structure and prominent in medicinal chemistry.</p>
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Photochemical Methods for the Construction of C-C and C-X Bonds
This thesis encompasses photochemical methods for the construction of C-C and C-X bonds. Following an introduction on the challenges with photochemistry, early work in photoredox catalysis and the application of continuous processing for photochemical reactions are three research chapters. Chapter …
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Organokatalytická příprava spirocyklických sloučenin odvozených od heterocyklů
Tato bakalářská práce se zaměřuje na enantioselektivní syntézu heterocyklicých spirosloučenin za využití organokatalytického přístupu. První část práce se zabývá enantioselektivní přípravou spirosloučenin reakcí α,β-nenasycených aldehydů s heterocyklickými sloučeninami, při které je použit chirální …