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Showing 1 to 20 of 39 for “"Spirochete"”.
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The Relapsing Fever Spirochete, Borrelia Hermsii, and Complement Regulatory Proteins
Borrelia hermsii, the primary etiological agent of tick-borne relapsing fever in North America, binds the complement regulatory protein factor H (FH) as a means of evading opsonophagocytosis and the alternative pathway of complement. The sequence of the gene encoding the FH-binding protein has been …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… characterization of an RNase III enzyme from a spirochete and its role in processing rRNA transcripts from the unusual rRNA gene operons of Borrelia burgdorferi. In most bacteria, the three rRNA transcripts (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… characterization of an RNase III enzyme from a spirochete and its role in processing rRNA transcripts from the unusual rRNA gene operons of Borrelia burgdorferi. In most bacteria, the three rRNA transcripts (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from …
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Next-Generation Sequencing of vlsE Recombinational Switching in the Lyme Spirochete
Borrelia burgdorferi and other spirochetes that cause Lyme disease effectively evade the acquired immune response through antigenic variation. The VlsE antigen is expressed on the spirochete surface during mammalian infection. Virtually unlimited numbers of variants are generated through segmental …
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Characterization of cyclic-di-GMP signaling with the Lyme spirochete, Borrelia burgdorferi
… burgdorferi, B. garinii, and B. afzelii. These spirochetes experience environmental fluctuations as they are passed between mammalian and Ixodes tick hosts throughout their enzootic cycle. Recent studies have suggested cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger, is a key …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… the first sRNA, DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the virulence-associated major outer …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… the first sRNA, DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the virulence-associated major outer …
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Investigation into peptidoglycan biosynthetic enzymes from the Lyme disease spirochete Borrelia burgdorferi
B. burgdorferi, the causative agent of Lyme disease, has unique chemical characteristics within its peptidoglycan (PG), such as the incorporation of L-Ornithine. This unusual structural feature may be implicated in immune evasion and may contribute to chronic symptoms such as Lyme arthritis and …
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Regulation of outer surface lipoprotein A in the Lyme disease spirochete Borrelia burgdorferi
Borrelia burgdorferi, a bacterium which causes Lyme disease, is maintained in nature through a cycle involving two distinct hosts: a tick vector and a mammalian host. To adapt to these two diverse environments, B. burgdorferi undergoes dramatic alterations in its surface lipoprotein. Two essential …
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Whisper out loud!: Spirochete, a living newspaper, 1937-1939, produced by the Federal Theatre Project: an instrument for public health education in the war on syphilis
… examined the Federal Theatre's Living Newspaper Spirochete, a dramatized history of syphilis, and its relationship to public health education during the late 1930s. The materials for this historical case study were found in the Library of Congress Federal Theatre Project Special Collection, …
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The Role of the Mismatch DNA Repair Protein MutL in Antigenic Variation of the Lyme Disease Spirochete
Antigenic variation is one of the immune evasion mechanisms employed by Borrelia burgdorferi to establish a persistent infection in the host through changes of its outer membrane lipoprotein, VlsE, by recombinational events at the vls locus. A recent study identified a requirement for the …
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Hydrogenation of Unsaturated Fatty Acids by Treponema (Borrelia) Sp., Strain B Sub 2 5, a Rumen Spirochete
Made available in DSpace on 2015-05-12T22:36:27Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7207119.PDF: 2742045 bytes, checksum: af3aed1028e956daa3ee5f462881b6be (MD5) Previous issue date: 1971
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Coping with stress: How Reactive Oxygen and Nitrogen Species alter the transcriptional landscape of the Lyme disease spirochete Borrelia burgdorferi
Borrelia burgdorferi, the Lyme disease spirochete, modulates expression of distinct sets of lipoprotein-encoding genes to successfully infect its tick vector Ixodes scapularis and various mammalian hosts. Lipoprotein expression is controlled by a limited number of transcription factors in response …
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Physiological Factors Affecting the Bactericidal Activity of the Western Fence Lizard (Sceloporus occidentalis) for the Lyme Disease Spirochete, Borrelia burgdorferi
… is the vector for the Lyme disease causative spirochete bacterium <em>Borrelia burgdorferi</em> in the western United States.<em> </em>Because <em>S. occidentalis</em> is reservoir incompetent and capable of eliminating spirochetes from infected ticks, it has been implicated as a major factor …
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The Characterization of Several Intestinal Spirochetes of Animal Origin
… of this study were: (1) to isolate an intestinal spirochete from a nonhuman primate and to characterize it along with several other intestinal spirochetes from a pig, dog, mouse, opossum, and gibbon on the basis of structural and selected biochemical characters, (2) to evaluate these properties …
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Identification of bptA (bbe16) as an Essential Gene for the Persistence of the Lyme Disease Spirochete, Borrelia Burgdorferi, in its Natural Tick Vector
… BptA may be widely utilized by Lyme borreliosis spirochetes for persistence in nature. Given B. burgdorferi's absolute dependence on and intimate association with both its arthropod and mammalian hosts, this study has provided evidence that bptA is a virulence factor critical for B. burgdorferi's …
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Vector Potential of Two Southeastern Tick Species (Acari: Ixodidae) for a Northeastern Strain of the Lyme Disease Spirochete, <em>Borrelia burgdorferi</em> Sensu Stricto
… <em>minor</em> larvae were able to acquire spirochetes (66%, n = 50) but only maintained an infection rate of 26% (n = 90) transstadially into the nymphal stage. <em>Ixodes</em> <em>scapularis</em> maintained an infection rate of 76% (n = 41) transstadially from larvae to nymphs. Moreover, …
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Studies of the Falls Creek (Texas) strain of relapsing fever spirochetes: Part I. Epidemiological and ecological studies. Part II. Serological studies of the "ticktorium" strain of Borrelia recurrentis var turicatae
… for studying the serology of relapsing fever spirochete infections in small animals, has been described. Spirochete immobilization (spirochaeticidal activity) has been established as the best of the various antibody phenomena to utilize in studying the serology of Borrelia recurrentis var …
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Cyclic-di-GMP Signaling in the Borrelia Spirochetes
… of a c-di-GMP binding protein in any spirochete, but also represent the first demonstration of the importance of PilZ domain proteins in a spirochetal system. We additionally examined the effects of c-di-GMP synthesis and breakdown in the related bacterium, B. hermsii, a causative …
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OspC in the pathogenesis of Borrelia burgdorferi
… 6-AA of the C-terminus of OspC resulted in lower spirochete burdens in heart and joint, whereas deletion of 9-AA resulted in higher spirochete burden in skin, indicating the tissue-dependent effects resulting from the deletion of the C-terminal sequence. Taken together, these results indicate that …
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