Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Spiral Ganglion Neurons"”.
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Wnt Signaling in Growth Cone Mediated Neurite Outgrowth from Spiral Ganglion Neurons in the Adult Mouse
… that can restore hearing by directly stimulating spiral ganglion neurons with electrodes implanted in the inner ear. However, the success of cochlear implants in older patients is limited by the reduced availability of surviving neurons that can be targeted with electrical stimulation, the …
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Computational Models Explaining Cochlear Implant Principles: A Hypothesis, Applications and Physical Validations
… a novel in-vitro model for studying responses of spiral ganglion neurons (SGNs) to CIs. Overall, this thesis aims to advance our understanding of CI principles and opens up new possibilities for research in the field of auditory prosthetics.
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The outer spiral network and its innervation by the olivocochlear system
… projections of olivocochlear (OC) and type-II spiral ganglion neurons. Type-II neurons innervate up to 100 OHCs, but their function is unknown. It has been suggested that type-II neurons interconnect neighboring OHCs through reciprocal synapses, which are bi-directional (afferent and efferent) …
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Early onset of age related hearing loss in LDHB knock out mouse
… with an age depended loss of sensory hair cell, spiral ganglion neurons, and stria vascularis cell in the inner ear(Gates and Mills,2005 and Yamasoba et al., 2007). The progressive loss of these cells finally results in hearing loss because hair cells and cochlear neuron cells do not regenerate. …
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ORAL ADMINISTRATION OF EPIGALLOCATECHIN-3-GALLATE (EGCG) IS A POTENTIAL THERAPEUTIC FOR CISPLATIN-INDUCED HEARING LOSS
… cells (OHCs) in basal turn of the cochlea, to spiral ganglion neurons (SGN), stria vascularis (SV) and fibrocytes of spiral ligament (SL). At the cellular level, cisplatin produces profound increases in reactive oxygen species (ROS) that stimulate cell signaling pathways leading to cochlear …
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Unravelling Spiral Ganglion Neuron Electrophysiology: Heterogeneity, Gene Therapy, and In-Vitro Testing Models
… CI performance is a better understanding of spiral ganglion neurons (SGNs). CIs work by directly and electrically stimulating SGNs, thus their performance depends on healthy and excitable SGN populations. This thesis comprises a multifaceted approach aimed at improving CI performance by …
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Biohybrid Neural Interfaces: Exploring the Role of Regional Astroglia in Neuronal Integration and Functionality
… to neural implantation by incorporating living neurons and traditional neural implants. This creates a dynamic cellular environment that allows for more natural interactions with host neural tissues. Given that BNIs incorporate living neurons, their functionality is potentially impacted either …
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Investigation of Sensory Cell-Specific Changes in Gene Expression in Microrna-183 Family Knockout Mouse Inner Ear From Bulk RNA Sequencing Analysis
… These microRNAs are expressed in sensory neurons and sensory epithelial hair cells. The miRNA-183 family has been linked to hereditary deafness in both humans and mice.To investigate the potential roles of the miR-183 family in the inner ear, our research team conducted bulk RNA sequencing …
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CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS
… such as organ of Corti, stria vascularis (SVA), spiral ligament (SL) and spiral ganglion neurons (SG). This leads to increased synthesis of pro-inflammatory cytokines, disruption of mitochondrial membrane integrity, activation of DNA damage/repair pathways and activation of pro-apoptotic enzymes. …