Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Spiral Ganglion"”.
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Development of spiral ganglion cells in syrian golden hamster
… on ultrastructural changes in the type I spiral ganglion cells (SGC) of the cochlea during the period of functional maturation using the Syrian golden hamster (LVG strain). Cochleas were taken from 6 day old to 30 day old animals in two day intervals, inclusively. Mature 36 day old …
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Unravelling Spiral Ganglion Neuron Electrophysiology: Heterogeneity, Gene Therapy, and In-Vitro Testing Models
… CI performance is a better understanding of spiral ganglion neurons (SGNs). CIs work by directly and electrically stimulating SGNs, thus their performance depends on healthy and excitable SGN populations. This thesis comprises a multifaceted approach aimed at improving CI performance by …
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Wnt Signaling in Growth Cone Mediated Neurite Outgrowth from Spiral Ganglion Neurons in the Adult Mouse
… that can restore hearing by directly stimulating spiral ganglion neurons with electrodes implanted in the inner ear. However, the success of cochlear implants in older patients is limited by the reduced availability of surviving neurons that can be targeted with electrical stimulation, the …
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Identification and Characterisation of New Mouse Models for Hearing Loss
… ear cell types (inner and outer hair cells, spiral ganglion and stria vascularis), and investigation of targets downstream of MAP3K1 identified increased p38 phosphorylation in these cells. The goya mutant reveals a signalling molecule involved with hair cell development and survival. Boycie …
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Olfactory progenitor cell transplantation into the mammalian inner ear
… predominantly within the vestibule and basal spiral ganglion regions. Furthermore, the addition of the ototoxin, cisplatin and the neurotrophin, Brain Derived Neurotrophic Growth Factor (BDNF) enhanced the survival and migration/dispersion of c17.2 cells within the cochleovestibular explant. …
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Investigation of Sensory Cell-Specific Changes in Gene Expression in Microrna-183 Family Knockout Mouse Inner Ear From Bulk RNA Sequencing Analysis
… changes in the cochlear sensory epithelium and spiral ganglion due to miR-183 family loss-of-function. However, these changes in gene expression represent an average across the entire tissue and do not provide insight into cell-specific gene expression. To address this, I combined existing bulk …
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Computational Models Explaining Cochlear Implant Principles: A Hypothesis, Applications and Physical Validations
… a novel in-vitro model for studying responses of spiral ganglion neurons (SGNs) to CIs. Overall, this thesis aims to advance our understanding of CI principles and opens up new possibilities for research in the field of auditory prosthetics.
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The outer spiral network and its innervation by the olivocochlear system
… projections of olivocochlear (OC) and type-II spiral ganglion neurons. Type-II neurons innervate up to 100 OHCs, but their function is unknown. It has been suggested that type-II neurons interconnect neighboring OHCs through reciprocal synapses, which are bi-directional (afferent and efferent) …
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Early onset of age related hearing loss in LDHB knock out mouse
… with an age depended loss of sensory hair cell, spiral ganglion neurons, and stria vascularis cell in the inner ear(Gates and Mills,2005 and Yamasoba et al., 2007). The progressive loss of these cells finally results in hearing loss because hair cells and cochlear neuron cells do not regenerate. …
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ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… cochlear nerve and CD3 positive staining in the spiral ganglion, organ of corti, and scala tympani. This same damage was not observed in IFNabgR-/- mice although those mice developed systemic infection with higher virus loads in most tissues. This indicates that the damage to the cochlear nerve …
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Electro-anatomical models of the cochlear implant
… present, as are differential amounts of residual spiral ganglion survival, fibrous tissue formation and electrode encapsulation, cochlear ossification, and idiosyncratic damage to adjacent cochlear structures. Because of the complex geometric electrical properties of the tissues found in the …
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ORAL ADMINISTRATION OF EPIGALLOCATECHIN-3-GALLATE (EGCG) IS A POTENTIAL THERAPEUTIC FOR CISPLATIN-INDUCED HEARING LOSS
… cells (OHCs) in basal turn of the cochlea, to spiral ganglion neurons (SGN), stria vascularis (SV) and fibrocytes of spiral ligament (SL). At the cellular level, cisplatin produces profound increases in reactive oxygen species (ROS) that stimulate cell signaling pathways leading to cochlear …
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Clinical and Molecular Characterization of Auditory Neuropathy
… of an MTS patient showed near complete loss of spiral ganglion cells, but preservation of the organ of Corti. NSRAN individuals with OTOF mutations benefit from cochlear implantation. No one with MTS is known to have been implanted, but the temporal bone studies suggest they might not benefit. …
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Biohybrid Neural Interfaces: Exploring the Role of Regional Astroglia in Neuronal Integration and Functionality
… astroglia, forming functional connections with spiral ganglion neurons on microelectrode array (MEA) plates. This proof-of-concept underscores the critical role of astroglia in enhancing BNI design and their potential for clinical applications, notably in cochlear implants. In summary, our work …
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TARGETING COCHLEAR INFLAMMATION FOR THE TREATMENT OF CISPLATIN OTOTOXICITY
… hair cells (OHCs), stria vascularis (SVA) and spiral ganglion cells (SG) of the cochlea, leading to hearing loss after cisplatin treatment. However, the mechanism(s) underlying the transition from ROS generation to the manifestation of ototoxicity is (are) not clearly defined. Recent studies …
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CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS
… such as organ of Corti, stria vascularis (SVA), spiral ligament (SL) and spiral ganglion neurons (SG). This leads to increased synthesis of pro-inflammatory cytokines, disruption of mitochondrial membrane integrity, activation of DNA damage/repair pathways and activation of pro-apoptotic enzymes. …
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Bedeutung des "vasodilator-stimulated phosphoprotein" (VASP) für die Entwicklung des Hörvermögens von Säugetieren - eine experimentelle Studie an Mäusen -
… anderseits das Wachstumsverhalten von Spiralganglienzellexplantaten der WT- und VASP(-/-)-Tiere in Zellkultur auf Lamininbeschichtung und unter NT-3 Stimulation analysiert. Bei den elektrophysiologischen Untersuchungen zeigten sich keine signifikanten Unterschiede im Hörvermögen adulter …
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Effects of Korean Red Ginseng against Ototoxic Drugs and Age-related Cochleo-vestibular Dysfunction
… and between the 3-NP and 3-NP + KRG groups. Spiral ganglion cell degeneration in the 3-NP group was more severe than that in the 3-NP + KRG group. In the third study, No mice in the control and KRG1 groups died at the age of 12 month, however, 4 in 7 mice died in the KRG (500 mg/kg) group. …