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Showing 1 to 3 of 3 for “"Spinocerebellar ataxia type 10."”.
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Molecular Pathogenesis of Spinocerebellar Ataxia type 10
… of nucleotide repeat within a target gene. Spinocerebellar ataxia type 10 (SCA10) is a unique autosomal dominant cerebellar ataxia (ADCA). The presence of seizure in addition to pancerebellar ataxia is a characteristic clinical manifestation of SCA10. More interestingly, the genetic mutation …
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Molecular Pathogenesis of Spinocerebellar Ataxia type 10
Spinocerebellar ataxia type 10 (SCA10) is a unique autosomal dominant cerebellar ataxia (ADCA) which habors non-coding ATTCT repeat expansion on the 9th intron of the ATXN10 gene. The presence of seizure in addition to pancerebellar ataxia is a characteristic clinical manifestation of SCA10. How …
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A mechanism for SCA10 neurodegeneration due to intronic repeat expansion
Spinocerebellar ataxia type 10 (SCA10) is the second most prevalent ataxia in Mexico and Brazil. Phenotype of the disorder first occurs around the third to fourth decade, generally after procreation, resulting in a highly transmissible autosomal dominant disease. SCA10 begins as gait ataxia, but as …