Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 166 for “"Spines"”.
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Morphological Study of Dendritic Spines
… structure and the characterisation of dendritic spines is nowadays a hot topic in neurobiology research. Dendrites are cellular structures whose main objective is to conduct the electrochemical stimulation received from other neural cells to the cell body of the neuron from which the dendrites …
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Exploring the morphospace of cidaroid echinoid spines.
… to selective pressures around them. Echinoid spines directly interact with their surroundings and morphologies should reflect environmental conditions changing through time. To quantify trends in morphology through time, 2D geometric morphometrics were applied to cidaroid spines to track …
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Cyclic and Mechanical Testing of Instrumented Swine Spines.
Deformities of the spine in the form of abnormal lateral curvatures have been noted throughout history. These deformities, if left to progress, can become very pronounced and respiratory problems often follow. The treatment for less severe curvatures usually consists of external bracing of the …
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A Comparison of the Pectoral Spines in Virginia Catfishes
Catfish pectoral spines are an anti-predator defense mechanism. They can be bound or locked, making the fish harder to swallow, or used to produce distress calls by rubbing ridges on the dorsal process against a channel in the wall of the pectoral girdle. Growth of the pectoral spine and girdle …
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Functional and ultrastructural investigation of mouse and human dendritic spines
Dendritic spines are the physical site of the majority of excitatory synaptic connections in the mammalian brain. Their complex morphological attributes and protein composition have inspired decades of theoretical and experimental work on how classes of dendritic spines differentially sculpt input …
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Spatiotemporal Dynamics of CaMKI During Structural Plasticity of Single Dendritic Spines
… imaging, while inducing LTP in single dendritic spines of rat (Rattus Norvegicus, strain Sprague Dawley) hippocampal CA1 pyramidal neurons using 2-photon glutamate uncaging. Using RNA-interference and pharmacological means, we also characterize the role of CaMKI during spine structural …
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Quantifying Acacia defences : understanding the role of hooks, spines and architecture
… of differences in thorn type (hooks versus spines) and branching architecture. This study aims to develop methods for quantifying the effectiveness of defences, thereby allowing for comparisons between individuals and localities. Measurements of a range of thorn and branching parameters of …
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Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
Dendritic spines are the main sites of synaptic input onto excitatory neurons. As recent experiments showed that synaptic activity and especially long-term potentiation (LTP) can modify spine morphology and number, I studied the effect of long-term depression (LTD) on these parameters. I used a …
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The Protective Effects of Memantine On The Morphology and Activity of Irradiated Dendritic Spines
… <p><strong>Activity of Irradiated Dendritic Spines</strong><strong></strong></p> <p>Thanh T. Lam, M.S.</p> <p>Advisory Professor: David R. Grosshans, M.D, Ph.D.</p> <p>Although radiotherapy is an effective treatment for brain tumors, the adverse effects of such treatments may result in a …
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Sensory exploitation and condition indication may explain red pelvic spines in the brook stickleback Culaea inconstans
… with and without red coloration on their pelvic spines. I presented fish with a paired choice between a red versus an orange, yellow, green, blue, or purple bead, and recorded the proportion of bites at each color. I tested for sexual dimorphism in pelvic spines and made observations on their use …
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Calcium dynamics in dendrites and spines of spiny neurons in the somatosensory ‘barrel’ cortex of the rat
… to study the Ca2+ dynamics in dendrites and spines of spiny neurons of layer 4 of the somatosensory cortex in acute thalamocortical brain slices of young (P13-P15) rats. Back-propagating action potentials (bAPs) resulted in a transient rise in Ca2+ in all dendrites and spines tested, …
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Use of High Pressure Liquid Chromatography to Detect and Quantify Oxytetracycline Marks in Walleye Otoliths and Dorsal Spines
… quantifying OTC in otoliths of fry-marked and spines of fingerlingmarked walleyes. Study objectives were to validate methodology of extraction of OTC from calcified tissue, detect and quantify extracted OTC using HPLC, and determine a cost comparison of current visual detection methods and …
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When good synapses go bad: dendritic spine dysgenesis in a mouse model of Fragile X mental retardation
… models of the disorder. Specifically, dendritic spines, thorn-like protrusions associated with synapses, appear “immature”: often exhibiting abnormal length and shape, and found in higher than typical density in many brain regions. The phenotype described is consistent with the hypothesis that …
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Dendritic Spine Density Varies Between Unisensory and Multisensory Cortical Regions
… those contacts. Furthermore, dendritic spines dynamically change in shape and number in response to a variety of factors. Dendritic spine numbers are reduced in mental retardation, enhanced during development, sensory enrichment or physical exercise, or fluctuate during the reproductive …
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A Three-Molecule Model of Structural Plasticity: the Role of the Rho family GTPases in Local Biochemical Computation in Dendrites
… has been directed towards the study of dendritic spines, small protrusions emanating from neuronal dendrites that constitute the majority of recipient sites of excitatory neuronal connections. The unique, mushroom-like morphology of these tiny structures has earned them considerable attention, …
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On the Geometric Characterization of the Lenke Classification Scheme for Idiopathic Scoliosis
… on the spine, one can generate "virtual" spines in a three-dimensional environment. The Scoliosis Learning Tool includes algorithmic steps that determine the Lenke Classification of the "virtual" spines. The Lenke Classification is the most commonly accepted method for diagnosing spinal …
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A homotopy reciprocity law for ribbon disc complements
In this paper, we present two new spines for ribbon disc complements. We describe Craggs's 3-dimensional spine and introduce a 2-dimensional spine ${\cal W}\sp2$ which we show satisfies the homotopy reciprocity law. We demonstrate that the reciprocity property remains invariant under insertions and …
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Morphological characterization of medium spiny neuron development in vitro
… excitatory (glutamatergic) signals. Dendritic spines undergo structural and functional changes during development, normal aging, and disease. To date, no studies have specifically characterized the developmental changes undergone by MSN dendritic spines and investigation into the molecules that …
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RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS
… processes at presynaptic terminals and dendritic spines. It promotes the stabilization of the NMDA-type glutamate receptors (NMDARs) at the cell surface, forming a ternary complex with the PSD-95 and GluN2A subunit of the receptor. This complex is needed for long-term potentiation (LTP) induction …
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Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo
… a significant fraction is present on dendritic spines, alongside an excitatory synapse. Inhibitory synapses on these dually innervated spines are remarkably dynamic and in stark contrast to the stability of excitatory synapses on the same spines. Many of the inhibitory synapses on dendritic …
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