Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Spine density"”.
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Dendritic Spine Density Varies Between Unisensory and Multisensory Cortical Regions
In the brain, the dendritic spine is a point of information exchange that extends the neuronal surface on which synapses occur, as well as facilitates and stabilizes those contacts. Furthermore, dendritic spines dynamically change in shape and number in response to a variety of factors. Dendritic …
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Exploring the role of Rapgef6 in neuropsychiatric disorders
… In vivo neural morphology assessment found CA3 spine density and primary dendrite number were reduced in knock out animals but additional hippocampal measurements were unaffected. Furthermore, amygdala spine density and prefrontal cortex dendrites were not changed. Considering all levels of …
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Neurobiological mechanisms underlying episodic memory retrieval
… lacked augmented synaptic strength and dendritic spine density. We proposed that a specific pattern of connectivity of engram cells may be the crucial substrate for memory information storage and that augmented synaptic strength and spine density critically contribute to the memory retrieval …
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A role for the SHANK1 scaffold protein in experience-induced synaptic plasticity and memory consolidation
… numerous studies have suggested dendritic spine plasticity across development and during learning as a likely process for memory consolidation. During early postnatal development, dendritic spine density increases in numerous sensory cortices, reaching a peak in adolescence, followed by a …
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Cellular and Synaptic Morphology of Golgi -Impregnated Cortical Neurons in Patients With Schizophrenia
… pyramidal neurons: dendrites and dendritic spines, and whether these alterations differ across brain region, cortical layer, cell type, or antipsychotic treatments. Formalin-fixed tissue blocks from frontopolar cortex, Area 10, and primary visual cortex, Area 17, were acquired from a pool of …
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The Role of Nogo-A in Memory and Neuronal Plasticity in the Aged Rodent Brain
… as dendritic sprouting and increased dendritic spine density in the contralateral sensorimotor cortex. In the present project we aimed to investigate whether anti-Nogo-A immunotherapy improves performance on a spatial memory task after a sensorimotor cortical stroke in aged rats. We found that …
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The Protective Effects of Memantine On The Morphology and Activity of Irradiated Dendritic Spines
… <p><strong>Activity of Irradiated Dendritic Spines</strong><strong></strong></p> <p>Thanh T. Lam, M.S.</p> <p>Advisory Professor: David R. Grosshans, M.D, Ph.D.</p> <p>Although radiotherapy is an effective treatment for brain tumors, the adverse effects of such treatments may result in a …
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Anatomy and Function of Synaptic Zinc in the Striatum
… regions of the striatum showed an increase in spine density in both genotypes, with enriched ZnT3 KO mice having a greater increase in the nucleus accumbens region. ZnT3 mice were also tested on a battery of motor behavioural tasks. ZnT3 KO mice may be hyperactive, as evidenced by their …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
… lower parvalbumin labeling and lower dendritic spine density, features similar to those observed in human condition. GluN2C heterozygous and knockout mice also exhibit behavioral and cognitive deficits relevant to schizophrenia. Moreover, a GluN2C/GluN2D potentiator, CIQ, attenuated NMDAR …
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A More General Role for the Fragile X Mental Retardation Protein in Pruning of Both Synaptic and Dendritic Processes
… in regulating dendritic development. Finally spine analysis of adult FraX somatosensory cortical layer V pyramidal neurons revealed (4) increased spine density, increased spine length, more spines with an immature and fewer spines with a mature morphology, consistent with analyses of other …
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Influence of Sex, Adolescence, and Aging on the Rat Basolateral Amygdala
… in both sexes, along with a sex difference in spine density across age. In study two, neuron number was quantified with stereological methods in the male and female basolateral amygdala at four different ages across the lifespan. The period between adolescence and adulthood was found to be …
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Role of mGluR5 and FMRP in mouse primary somatosensory cortex
… cortical connectivity, particularly dendritic spine dysgenesis. There is also an emerging view that aberrant local protein synthesis within dendrites and protein trafficking to dendrites underlies some forms of MR (Kelleher and Bear, 2008; Pfeiffer and Huber, 2006; Zalfa and Bagni, 2005). Most …
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Physiological Effects of Estradiol in the Mouse Hippocampal Formation
… synaptic plasticity, including dendritic spine density, synapse density, and synaptic protein expression. In some cases, these changes are associated with alterations in mood and hippocampal-dependent learning and memory. The upstream mediators of these estradiol effects remain unknown, …
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Development and characterization of novel transgenic techniques for the study of neuronal circuitry
… a 15% - 19% decrease in apical dendritic spine density. Finally, we also describe the attempt to create additional Cre-driven mouse lines that would allow conditional alteration of neuronal activity either by hyperpolarization or inhibition of neurotransmission. Overall, the models …
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Critical window in autism : a study on Shank3
… tracing technique to study the dendritic spine density, and found that the dendritic spine number is also significantly increased in the rescue condition after development. In addition, we show that while anxiety and motor coordination are not improved, social interaction and repetitive …
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Effects of Regional Deletion of Rab3A-interacting Molecule and PTEN on Brain Function
… it did increase soma volume, dendritic caliber, spine size, mushroom:thin spine ratio, and the frequency of spontaneous miniature excitatory post-synaptic currents. These findings are in contrast to previous findings of increased spine density with PTEN knockdown. This difference likely …
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The Role of High-Density Lipoproteins and Related Pathways in Alzheimer’s Disease
… established that high plasma levels of high-density lipoprotein (HDL) protect against cardiovascular disease and accumulating evidence indicates that the beneficial role of HDL extends to the central nervous system. There are several important biological mechanisms that regulate HDL …
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Anatomical and Functional Characterization of the Ventral Hippocampus in a Rodent Model of Schizophrenia Neuropathology
… Specifically, we found a decrease in dendritic spine density in specific regions of the dendrite of ventral subicular neurons. At the neurophysiological level, we observed abnormalities in afferent-evoked synaptic responses in the ventral subiculum. These changes were not however, accompanied by …
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The Role of CNTNAP2 in the Development & Evolution of the Human Cerebral Cortex
… function reduces neurite branching and dendritic spine density in vitro and in vivo. The potential evolutionary significance of this gene is highlighted by the presence of eight human accelerated regions (HARs), suggesting that there are human-specific aspects to its temporal and spatial …
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