Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Spindle apparatus"”.
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Morphological Remodeling of the Endoplasmic Reticulum During Mitosis and Its Influence on the Integrity of the Spindle Apparatus
… embryo led to an enhanced buildup of ER at the spindle poles and, interestingly, produced highly penetrant defects in the division cycles. Clustering of ER around the mitotic space is negatively correlated with spindle length and microtubule intensity. Importantly, the recruitment of several key …
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The evolution of centrosome and chromosome number in newly formed tetraploid human cells
… the cell's microtubule cytoskeleton and mitotic spindle apparatus. Centrosome number homeostasis is crucial for health, and recent studies have shown inducing extra centrosomes in cells can induce tumor formation in mice. This has led some researchers to propose that the extra centrosomes that …
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Regulation der humanen Aurora-A Kinase und Identifikation potentieller Interaktionspartner
… bipolar array of microtubules, the mitotic spindle. Prominent amongst the regulators of the mitotic spindle is the serine/threonine-specific protein kinase Aurora-A. However, only a few interaction partners and physiological substrates of Aurora-A are know to date and the function of this …
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Eukaryotic chromosome segregation: New aspects of separase regulation by securin, Cdk1, PP2A and auto-cleavage
… chromosomes interact properly with the mitotic spindle apparatus does the anaphase promoting complex or cyclosome (APC/C), a multisubunit E3 ligase, mediate the ubiquitylation of securin and cyclin B1. Their subsequent proteasomal degradation then releases active separase. Murine embryonic stem …
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The Mitotic Spindle Mediates Inheritance of the Golgi Ribbon Structures
… Mitotic Golgi membranes concentrate around the spindle poles, suggesting that the spindle may control Golgi partitioning. To test this, cells were induced to divide asymmetrically with the entire spindle segregated into only one daughter cell. A ribbon reforms in the nucleated karyoplasts, …
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Synthesis and Molecular Pharmacology of the Diazonamides
… that induce the formation of mono-aster mitotic spindles. The synthesis of numerous analogs established structure activity relationships which guided the preparation of biotinylated, fluorescent, and radiolabeled forms of the natural product. These analogs were used in a variety of experiments to …
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The peptidyl-prolyl isomerase Pin1 is required for maintenance of the spindle assembly checkpoint
… with its essential co-activator Cdc20. The spindle assembly checkpoint (SAC) is a surveillance mechanism that monitors the chromosomes' interactions with the microtubules of the mitotic spindle apparatus. In response to even one erroneous attachment the affected kinetochore emits a "wait …
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Investigating the Biological Functions of the Protein Kinase WNK1 in the Regulation of Cytoskeletal Structures and Membrane Trafficking
The file named "TU-DISSERTATION-2013.pdf" is the primary dissertation file. Twelve (12) supplemental videos are also provided (in Audio Video Interleaved format).
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LOCALIZED WNT3A-SOURCES INSTRUCT MITOTIC ORIENTATION: DISSECTING THE WNT3A-TRANSDUCTION MECHANISM COUPLED WITH NUMA MACHINERY
… rely on the proper positioning of the mitotic spindle. Consistently, defects in epithelial polarity and spindle orientation are often coupled with loss of tissue architecture and altered proliferation. Since mitotic spindle orientation determines the axis of cell division, in stem cells it …
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Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning
… FAM83 member known to localise to the mitotic spindle. RNA interference approaches targeting FAM83D have been reported to impact chromosome alignment and cause a delay in the timings of cell division. Whilst all FAM83 proteins appear to associate robustly with the CK1 alpha isoforms (CK1α), …