Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Spin-trapping"”.
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Synthèse de Nouvelles Nitrones du Type Pyrroline-N-Oxyde et leur Utilisation en Spin-Trapping
Dans la recherche de nouveaux pièges pour identifier par RPE les radicaux libres présents dans les milieux biologiques, particulièrement le superoxyde et le radical hydroxyle, le laboratoire a récemment mis au point une nouvelle nitrone, le 2-diéthoxyphosphoryl-2-méthyl-3,4-dihydro- …
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Molecular basis of MPTP-induced Parkinson's disease
… The generation of ⋅O₂⁻ was further confirmed by spin-trapping in combination with EPR techniques using 5, 5-dimethyl-1-pyrrolonine-N-oxide (DMPO) as the spin trapping agent. The rate of formation of spin adduct (DMPO-O₂⁻) was dependent not only on the concentrations of MPDP⁺ and oxygen but also …
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The detection and characterisation of novel alkyl spin-adducts of PBN and its derivatives using capillary gas chromatography coupled to electron-ionisation mass spectrometry
… secondary radicals in the presence of the spin-trapping agent N-tert-butyl-a-phenylnitrone (PBN). Novel aldehyde related radicals were produced via Fenton chemistry and trapped using PBN to form stable adducts that could be analysed via the combined techniques of gas chromatography (GC) and …
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X-Band Rapid-Scan EPR
… EPR. Because of this, the energy absorbed by the spins, for the same microwave B<sub>1</sub>, is less than in conventional CW spectra, and the signal does not saturate as readily. For samples with long electron relaxation times, pulse techniques can also be challenging, particularly if …
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A study of mechanochemical reactions of spin traps in hydrocarbon polymers
The identification and quantification of spin adducts and their reduction products (>NOH, >NOR) formed from nitroso compounds and nitrones in EPR and PP during spin trapping techniques have been examined. The nitroxyl yield and polymer bound nitroxyl percentage formed from these spin traps were …
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Study of locally unfolded forms of cytochrome c by Fourier transform infrared and of H2O2-mediated oxidation of ferricytochrome c and metmyoglobin by mass spectrometry
… cyt c/H 2 O 2 reaction is ferric heme-mediated. Spin-trapping was coupled to peptide mass mapping (ST/LC/MS) to locate protein-based radicals formed during the reaction of cyt c and Mb with H 2 O 2 . Tyr74 in horse and cow cyts c and Trp33 in tuna cyt c were inferred as possible radical sites …
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The chemistry of some organotellurium compounds
… to carboxylic acids is catalysed by ditelluride. Spin trapping experiments with PhCH=N(O)But (phenyl-t-butyl-nitrone) have provided evidence that the oxidative addition of an alkyl halide (RX=Mei, BunBr, BusecBr, ButBr, BrCH2-CH=CHCH2Br, and Br(CH2)4Br) to diphenyltelluride and reductive …
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Ribonucleotide reductase in dividing cells: Purification and inhibition studies with 4-hydroxynonenal
… of CCl4 in rat liver microsomes was studied. Spin trapping of CCI3', covalent binding of CCl4 to protein and CCl4-dependent MDA formation were used as indices of CCl4 metabolism. Formation of PBN-CCI3' adduct, 14CCl4 covalent binding to protein and CCl4-dependent :MDA production were dependent …
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In vitro and in vivo studies on the biotransformation of β-nicotyrine, a minor tobacco alkaloid
… been trapped and detected by ESR analysis by spin trapping techniques. In contrast, only the starting substrate β-nicotyrine was found in the incubation mixture of β-nicotyrine with rat liver microsomes. The in vivo metabolic fate of β-nicotyrine has been examined in rabbits and mice by HPLC …
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Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
… dependent deoxyribose degradation assay and EPR spin trapping methods. HP was also found to quench singlet oxygen in a dose-dependent manner. HP was found to enhance the microsomal lipid peroxidation in a dose-dependent manner and at 10 µM it augmented the lipid peroxide accumulation by 100% …
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Pathogénie cellulaire et moléculaire du stress oxydatif dans l'ostéo-arthropathie dégénérative équine
… paramagnétique électronique (RPE) couplée au « spin trapping »]
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Testing oxidative-stress hypotheses generated by systems-biology assays
… DNA damage was caused by the Fenton reaction. Spin-trapping experiments confirmed that Hpx- yaaA cells had a higher hydroxyl radical level than yaaA+ strains. EPR analysis showed that the proximate cause was an unusually high level of intracellular unincorporated iron. These results demonstrate …