Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Spin Labels"”.
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Nitroxide Spin Labels as NMR Contrast Agents: Delivery, Metabolism and Relaxation
In this project, the potential of nitroxides as contrast agents for magnetic resonance imaging (MRI) has been studied. The difficulties involved in using nitroxides as in vivo MRI contrast agents, such as premature metabolic convertion of nitroxides to their nonparamagnetic state, lack of tissue …
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Solid/liquid intermolecular transfer of dynamic nuclear polarization - enhanced flowing fluid ¹H NMR signals via immobilized spin labels
… with stable immobilized nitroxide and phenoxy spin labels. The advantages of the flow SLIT DNP experiment in comparison with the recently reported flow liquid/liquid intermolecular transfer (LLIT) ¹H DNP experiment are discussed. The results suggest that the flow SLIT DNP experiment provides a …
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Metabolically Responsive Contrast or Imaging Agents for NMR or ESR Imaging: Metabolism of Nitroxides in Cells
The use of nitroxide spin labels in complex biological systems as biophysical tools to study molecular dynamics of membranes and cells and as contrast or imaging agents for NMR or ESR imaging and in vivo spectroscopy has led to a need to understand thoroughly the metabolism of nitroxides in cells. …
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Triplex formation as monitored by EPR spectroscopy and molecular dynamics studies of spin -probe -labeled DNAs
… molecules. Since the advent of nitroxide based spin-probes the electron paramagnetic resonance (EPR) study of spin-labeled macromolecules has been able to provide insight into structural and dynamics properties of DNAs, proteins, and related systems. Spin labels have been extensively used to …
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A study of SecA : the motor of the bacterial secretion system by site-directed spin labeling and EPR
… resonance (EPR) spectroscopy and site-directed spin labels at a multitude of sites on the surface of the 102 kDa SecA protein. EPR spectroscopy is sensitive to changes in the local environment of the spin label, and thus our survey of the SecA surface provided a map of interaction sites with its …
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Small molecule motion within and through organic nanomaterials: an anthology
… co-assembly of AAs with stable nitroxide radical spin labels into the nanoribbon ensemble. Distinct conformational behavior is resolved between domains, and variable temperature studies enable description of each spin label environment through phase transition characterization and activation …
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Structural Polymorphism in Tau Filaments: An Implication for Neurodegenerative Diseases
… has four repeats (4R tau).</p> <p>Site-directed spin labeling of recombinant tau in conjunction with electron paramagnetic resonance spectroscopy was used to obtain structural insights into tau filaments. The studies showed that the filaments of 4R tau and 3R tau share a highly ordered core …
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The Structure-Function Interface in the Cytochrome Bc1 Complex Family
… changes of the ISP. Using nitroxide spin labels or fluorophores, attached to genetically engineered cysteine residues we have determined biochemical conditions that may control such conformational changes under steady state conditions.
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Studies on the interaction of cholesterol analogues with cholesterol oxidising systems and membrane components
… in the required molar proportions. A series of spin labels (3-nitroxy octane, Tempo, 25 nitroxy cholestane, and 3 nitroxy cholestane) were incorporated into the sterol phospholipid liposomes and the effect of each analogue on each spin label mobility was observed. In addition the effect of each …
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Assessment of Brain Perfusion and Vascular Compliance with Magnetic Resonance Imaging
… I first developed a cardiac-triggered Arterial-Spin-Labeling (ASL) technique to enhance the sensitivity of brain perfusion MRI without using exogenous contrast agent. I demonstrated its utility in several experimental settings, including single-shot acquisition, multi-shot acquisition, and …
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A single-crystal EPR study of radiation-induced defects in selected silicates
… triatomic molecules and is widely used as spin labels in biophysical and biomedical research, in fluorapophyllite has been observed and characterized by single-crystal EPR spectra. Fourier-transform infrared (FTIR) spectrum supports electron-microprobe analyses that fluorapophyllite on the …