Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Spike activity"”.
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Embedding of synchronous spike activity in cortical networks
… of evidence for temporal interrelations in brain activity exhibits precisely timed spikes to be part of an important information concept, justifying a closer inspection of the underlying network mechanisms. As one such model, synfire chains are special feed-forward subnetworks that allow for …
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Characterizing Purkinje Cell Responses and Cerebellar Influence on Fluid Licking in the Mouse
… system in the form of population complex spike activity. These findings suggest that the olivo-cerebellar system is involved in the generating circuitry responsible for licking rhythm in rodents. However, the representation of licking in the simple spike activity of Purkinje cells and the …
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Spatio-temporal structure of thalamically evoked activity in the barrel cortex
… via thalamocortical pathways and ongoing activity thereby extracting the relevant details from spatio-temporal dynamic stimuli that carry information about the environment. In the course of this, the cortical response to the incoming information depends on the actual state of activity of …
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Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus
… I use light-gated ion channels to manipulate spike activity on a cycle-by-cycle basis in awake, behaving mice. By rhythmically stimulating fast-spiking interneurons in somatosensory cortex, I can emulate the activity patterns that define gamma oscillations under natural conditions. Emulating …
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Modification of Aplysia Feeding Network By L-Dopa and Dopamine-Dependent Learning
… of L-DOPA (40 or 250 mM) and then monitoring activity of up to 130 neurons simultaneously using a voltage-sensitive dye (RH-155). L-DOPA selected one of two distinct buccal motor patterns (BMPs): intermediate (low L-DOPA) or bite patterns (high L-DOPA). The selection of intermediate BMPs was …
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Concentration-dependent Effects of D-Methylphenidate on Frontal Cortex and Spinal Cord Networks in vitro
… responses to methylphenidate. The spontaneous spike activity of both tissues was inhibited in a concentration-dependent manner by serial additions of 1-500 µM methylphenidate. Methylphenidate is non-toxic as spike inhibition was recovered following washes. The average concentrations for 50% …
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Effect of Background Synaptic Activity on Excitatory-Postsynaptic Potential-Spike Coupling
… which may impact the coupling between EPSPs and spikes. We mimicked the<em> in vivo</em> synaptic activity of the cell with the dynamic clamp system. We recorded from pyramidal cells in neocortical slices<em> in vitro</em> to investigate how timing and probability of spike generation in response …
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Towards a Neural Measure of Value and the Modelling of Choice in Strategic Games
… term and makes action value observable in the spike rates of neurons. Action value is measured in the spike activity of the Superior Colliculus (SC) while monkeys play a saccade version of matching pennies. We find SC activity predicts upcoming choices and is influenced by the history of events …
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Evaluation of Zinc Toxicity Using Neuronal Networks on Microelectrode Arrays: Response Quantification and Entry Pathway Analysis
… analysis of the temporal evolution of network spike activity generation at specific zinc acetate concentrations. Cultures responded with immediate concentration-dependent excitation lasting from 5 to 50 min, consisting of increased spiking and enhanced, coordinated bursting. This was followed …
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Radiation-enhanced diffusion of oxygen-18 in uranium dioxide thin films
… mechanism of ion-mixing and that thermal spike activity is negligible.
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Determination of Dissociation Constants for GABAA Receptor Antagonists using Spontaneously Active Neuronal Networks in vitro
Changes in spontaneous spike activities recorded from murine frontal cortex networks grown on substrate-integrated microelectrodes were used to determine the dissociation constant (KB) of three GABAA antagonists. Neuronal networks were treated with fixed concentrations of GABAA antagonists and …
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Denoising techniques reveal neural correlates of modulation masking release in auditory cortex
… microelectrode array records multi-unit neural spike activity in core auditory cortex. In addition, microelectrodes also record nuisance signals due to animal movements and interference in the wireless recording setup. The current study examines the potency of three different denoising …
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Electrophysiological and morphological analyses in two species of insects, Protophormia terraenovae and Ceratitis capitata
… divided in two separate sections. Section 1: The spike generator in the labellar taste receptors of the blowfly is differently affected by 4-aminopyridine and 5-hydroxytryptamine In taste chemoreception of invertebrates the interaction of taste stimuli with specific membrane receptors and/or ion …
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Anatomical and physiological properties of the superior paraolivary nucleus in the rat
… to sound played in the contralateral ear with spike activity timed to the stimulus offset and phase lock to amplitude modulations in complex sounds. Pharmacologically blocking glycinergic input abolished the offset response (indicating that offset activity is a rebound from glycinergic …
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Phenotypic And Electrophysiologic Characterization of a Mouse Model of Fragile X Syndrome
… in Fmr1 KO mice. Single and multi unit spike activities and local field potentials (LFPs) were recorded in the whisker barrel cortex of awake mice. Baseline spike activity was significantly lower in cortical neurons of Fmr1 KO mice. Synchronous activity at the LFP was strongly reduced in …
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The effects of repeated amphetamine exposure during adolescence on behavior and prefrontal cortex function
… receptor function, and prefrontal cortex (PFC) activity, with a focus on the consequences of drug exposure during adolescence. Chapter 1 includes a review of the literature on substance abuse and PFC dysfunction along with the specific aims of the studies described in the following chapters. …
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NOVEL THERAPEUTIC APPROACHES EMERGING FROM HCN CHANNELS STRUCTURAL AND FUNCTIONAL STUDIES
… Ih current that regulates spontaneous electrical activity and synaptic integration in neurons. Mutations in the HCN1 gene have been linked to Early Infantile Epileptic Encephalopathy (EIEE) and a spectrum of neurodevelopmental disorders (ND). Despite the growing number of identified HCN1 variants, …
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Anatomical and Functional Characterization of the Ventral Hippocampus in a Rodent Model of Schizophrenia Neuropathology
… accompanied by changes in in vivo spontaneous spike activity in subicular neurons . In the mouse, MAM was found to have much less impact on brain development, as observed at the gross morphological level. However, these mice showed an increased sensitivity to some psychostimulants and a weak …
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Effects of isometric elbow flexion on electromyographic spike analysis
… between surface electromyographic (SEMG) spike activity and force. The secondary objective was to determine to what extent subcutaneous tissue impacts the high frequency component of the signal, as well as, examining the relationship between measures of SEMG spike shape and their …
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Computational studies of cerebellar cortical circuitry
… signals are encoded by the Purkinje cell complex spike discharge. The results presented in this thesis show that the Purkinje cell simple spike activity robustly signals a rich representation of task specific performance errors, independently from the kinematic signals. The results also show that …
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