Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Sphingosine Kinase Inhibitors"”.
-
Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors
Sphingosine kinase (SphK) has emerged as an attractive target for cancer therapeutics due to its role in cell proliferation. SphK phosphorylates sphingosine to form sphingosine-1-phosphate (S1P) which has been implicated as a major player in cancer growth and survival. SphK exists as two different …
-
Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors
… have been associated with elevated levels of sphingosine-1-phosphate (S1P). S1P, a pleiotropic lipid mediator involved in a broad range of cellular processes, is synthesized solely by the phosphorylation of sphingosine (Sph) and is catalyzed by the two isoforms of sphingosine kinase (SphK1 and …
-
Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers
Sphingosine 1-phosphate (S1P) is a cellular signaling molecule that has been implicated in a variety of diseases including cancer, fibrosis, Alzheimer's, and sickle cell disease. It is formed from the phosphorylation of sphingosine (Sph) by sphingosine kinase (SphK) and SphK exists as two …
-
Design, Synthesis, and Structure-Activity Relationship Investigation of Selective Sphingosine Kinase Inhibitors
Sphingosine kinase 1 (SphK1) is the key enzyme catalyzing the formation of sphingosine-1-phosphate (S1P), which is an important signaling molecule that regulates multiple biological process including inflammatory responses. Elevated SphK1 activity as well as upregulated S1P levels is linked to …
-
Structure-activity relationship studies and biological evaluation of selective sphingosine kinase inhibitors
Sphingosine 1-phosphate (S1P) has become a prevalent drug discovery target due to studies implicating it to several disease pathologies such as fibrosis, sickle cell disease, inflammation, diabetes, and cancer. S1P functions to induce cell proliferation and migration. S1P signaling occurs through …
-
Design, synthesis and biological evaluation of sphingosine kinase inhibitors for the treatment of prostate cancer
Sphingosine is phosphorylated via the action of the enzymes sphingosine kinase 1 (SK1) and sphingosine kinase 2 (SK2) to produce the bioactive signalling molecule sphingosine 1-phosphate (S1P). S1P drives cancer cell proliferation and migration whilst also promoting cell survival. Many studies have …
-
Metabolomic and metabolomic flux studies of the effects of sphingosine kinase inhibitors on prostate cancer cells using high-resolution mass spectrometry as an analytical technique
There is evidence of the involvement of sphingosine kinases (two isoforms termed SK1and SK2), which catalyse the formation of the bioactive lipid, sphingosine 1-phosphate(S1P), in various diseases including cancer. Over the last few years, metabolomics has become an increasingly critical part in …
-
Is there an association between S1P signaling and the transcription factor Nrf2?
… cancers to drugs, chemotherapy or radiotherapy. Sphingosine 1-phosphate is a biological lipid mediator that serves a pivotal function in physiological functions and pathophysiological conditions. Synthesized by sphingosine kinase, S1P regulates several cellular events through five sphingosine …
-
Nanoparticle-Based Drug Delivery and the Impacts on Cancer Cell Biophysical Markers
… cellular biophysical markers in response to sphingosine kinase inhibitors (SphKIs), and compared the effectiveness of drug delivery using Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with SphKIs versus conventional delivery. Cells treated with SphKIs showed significantly …