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Showing 1 to 20 of 37 for “"Spermine"”.
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A study of the Project for American Studies in the Secondary Schools and its effect on curricular change
… gall tumors, to assay levels of spermidine and spermine in normal and crown gall tumor tissue and to determine the effects of selected anti-tumor compounds on growth of crown gall tumors as well as on the endogenous levels of the polyamines in those tumors.Findings1. Spermidine and spermine are …
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Toxicology and pharmacology of N¹-acetylspermidine and N⁸-acetylspermidine
… N<sup>8</sup>-acetylspermidine, spermidine, spermine and putrescine, were determined by intraperitoneal injection in mice. The LD<sub>50</sub> for N<sup>1</sup>-acetylspermidine •2HCl and N<sup>8</sup>-acetylspermidine •2HCl were 1150 and 820 mg/kg, respectively, and the respective …
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Characterization of the expression profile of polyamine biosynthetic genes (Spermidine synthase) and polyamine metabolic regulation in arabidopsis
… decarboxylase) altered spermidine/spermine content much, which indicates a complex and tightly regulated machinery for higher polyamine homeostasis. The turn-over study on all three major polyamines showed a short half-life of 6-8 h for putrescine and longer ones for spermidine (>40 …
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Topologically constrained DNA intercalators: Synthesis and DNA binding studies
… Macrocycles 31 and 32 are linked via spermine at the 9-position and have been shown to bind to DNA by bisintercalation using absorption spectroscopy titrations, thermal denaturation studies, and viscometric titrations of both calf thymus DNA and closed circular supercoiled DNA. …
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Synthesis and use of new Porphyrin Derivatives
… design, synthesize, and test capabilities of new spermine-porphyrin and BODIPY derivatives, and to study their interactions with various biological targets. The research period was focused on the synthesis of porphyrin derivatives with a different number of spermine pendants, in order to combine …
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Dynamic combinatorial synthesis of donor-acceptor catenanes
… with a biologically relevant target – spermine – in water under near-physiological conditions. Its synthesis is improved if the salt is replaced by a sub-mM concentration of spermine, acting as a template. Chapter 4 explores in further detail how subtle variations in the building block …
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The potential antioxidant and anticancer properties of polyamines and their response to high-intensity ultrasonication
… roles in both plants and animals. The polyamines spermine, spermidine and putrescine have been of primary interest, as they participate in cell growth and proliferation and thus are involved in health, disease and aging. Polyamines are also reported as secondary metabolites in stress response in …
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The Role of Polyamines in Osmotic Stress Tolerance in Gulf Killifish Fundulus Grandis
… concentrations of putrescine, spermidine, and spermine. DFMO application inhibited Odc activity and reduced polyamine levels after hypoosmotic exposure (0.1 ppt). Although gill putrescine levels remained elevated throughout the first 7 d post transfer to 0.1 ppt, the concentrations of …
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The Structural Mechanism of Allosteric Modulation of The Nmda Receptor: A Balance of Tensions
… Endogenous modulators such as the zinc cation or spermine can inhibit and potentiate current through the receptor, respectively. The synthetic compound ifenprodil also binds the ATDs and inhibits the receptor. We used luminescence resonance energy transfer to study the structural changes …
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THE REGULATION OF POLYAMINES AND THEIR ROLE IN THE PROLIFERATION OF HELA CELLS
… was eliminated by the addition of 0.5 (mu)M-spermine or spermidine or 10 (mu)M-putrescine to the HeLa cell cultures at the time of refeeding with fresh medium. Much higher concentrations (1 mM) of the non-physiological diamines, 1,3-diaminopropane or 1,3-diamino-2-hydroxy-propane, were …
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A study of the formation of interstrand and intrastrand crosslinks through abasic site and cleaved abasic site chemistry
… and the subsequent reactions that occur after spermine-mediated strand cleavage at an abasic site.
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EFFECT OF NICOTINE ON LUNG S-ADENOSYLMETHIONINE AND PNEUMOCYSTIS PNEUMONIA DEVELOPMENT
… of the essential polyamines spermidine and spermine. In the target tissue of "Pneumocystis", the lung, levels of AdoMet were previously shown to be depleted experimentally using nicotine. Here we show that chronic administration of nicotine in an animal model of PcP resulted in decreased …
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ΜΕΛΕΤΗ ΤΗΣ ΒΙΟΣΥΝΘΕΣΗΣ ΤΩΝ ΠΟΛΥΑΜΙΝΩΝ ΣΤΑ ΒΛΑΣΤΗΜΕΝΑ ΣΠΕΡΜΑΤΑ ΚΡΙΘΑΡΙΟΥ
… AND CATIONS IN THE INCUBATION MIXTURE CO2+ AND SPERMINE ARE THE MOST EFFECTIVE AND CAUSE COMPLETE RELIEF OF THE IN VITRO INHIBITION OF ODC BY ANTIZYME AT 0.5 MM CONCENTRATION.
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ΣΥΣΤΗΜΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ ΕΛΕΥΘΕΡΟ ΚΥΤΤΑΡΩΝ ΑΠΟ ΣΥΚΩΤΙ ΠΟΝΤΙΚΟΥ C3HB
… WEAKLY ACTIVATES AT LOW CONCENTRATIONS AND SPERMINE IS HIGHLY INHIBITORY EVEN AT LOW CONCENTRATIONS. INCREASING CONCENTRATIONS OF SPERMIDINE INTENSIFY LABELLING OF AT LEAST TWO PROTEINS WITH M.W 14.5 AND 15.5 KD. EXOGENOUS MRNA (GLOBIN MRNA, TMV RNA) CAN BE TRANSLATED IF THE SYSTEM IS …
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Development and characterization of cell-free amino acid incorporation systems from <u>Cellvibrio gilvus</u>
… 300° C, respectively. Polyamiaes (putrescine, spermine, and spermidine) had a slight stimulatory effect on poly U-directed.¹⁴C-phenylalanine incorporation, but no effect on ¹⁴C-Leucine incorporation.
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Polyamine metabolism in Arabidopsis: Transgenic manipulation and gene expression
… of polyamines (Putrescine, Spermidine and Spermine) in wild type and transgenic Arabidopsis thaliana (Col 0 ecotype) plants was studied using the techniques of transgenic manipulation and gene expression. Two specific objectives were: (1) To study the effects of inducible and constitutive …
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Understanding polyamine metabolism through transgenic manipulation in poplar suspension cultures
… in plants are putrescine, spermidine, and spermine. Suspension cultures of poplar (Populus nigra x maximowiczii), transformed with a mouse ornithine decarboxylase gene (under the control of a 2X 35S CaMV promoter) were used to study the impact of up-regulation of putrescine biosynthesis …
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Transgenic manipulation of polyamine metabolism in poplar
… increase in spermidine, and a small reduction in spermine as compared with non-transgenic (NT) cells. The conversion of labeled ornithine into putrescine was significantly higher in the transgenic than the NT cells.</p><p>The results show that: (a) Transgenic expression of a heterologous odc gene …
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Processive Acceleration of Actin Barbed End Assembly by N-WASP
… enhancements. Increasing polycationic Mg2+ or Spermine to enhance filament bundling increased the frequency of filament buckle formation, consistent with a requirement of accelerated assembly on barbed end bundling. Our preliminary data shows that tethered N-WASP construct containing one WH2 …
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