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Showing 1 to 12 of 12 for “"Spermatogonial stem cells"”.
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Do environmental toxicants target signaling in spermatogonial stem cells?
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2012-09-17T21:51:23Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Lucas_Benjamin.pdf: 70622856 bytes, checksum: 2fd86bb1981472cfe6384605ec1ee963 (MD5)
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The Role of Differential Sensitivity to Retinoic Acid (RA) in Regulating Spermatogonial Fate
… the foundation of spermatogenesis is provided by spermatogonial stem cells (SSCs); their progeny either remain as stem cells (following a self-renewal division) or proliferate as undifferentiated progenitors prior to differentiating in response to retinoic acid (RA) and later entering meiosis. The …
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Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
Spermatogonial stem cells (SSCs), as the foundation for spermatogenesis, must maintain a balance of both self-renewal and differentiation. Although several factors important for these processes have been identified, the fundamental mechanisms regulating SSC self-renewal and differentiation remain …
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Mechanism of Spermatogonial Stem Cell Regulation by ETV2
… is the process through which male germ cells give rise to spermatozoa. Spermatogenesis is initiated from spermatogonial stem cells (SSCs) which self-renew or differentiate to give rise to differentiated progenies of germ cells. Hence understanding of SSC biology is essential to …
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Selfish Mutations: the Genetic Basis of the Paternal Age Effect
… to selfish mutations: substitutions that grant spermatogonial stem cells (SSCs) a selective advantage in the testes of the father but have a deleterious effect in offspring.</p> <p>I present a mathematical model to analyse the normal function of the stem cell compartment, which provides a …
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Quantifying expression variability in single-cell RNA sequencing data
… has been broadly studied in prokaryotic model systems or by profiling individual genes, few whole-transcriptome studies in mammalian systems have been reported. The development of single-cell RNA sequencing technologies introduced powerful tools to investigate transcriptional differences between …
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Multi-cycle cisplatin treatment alters spermatogonial functional stem cell behavior and niche
… men. Undifferentiated spermatogonia, including spermatogonial stem cells (SSCs), are theoretically capable of repopulating the seminiferous tubules after exposure has ceased. It is proposed that an altered spermatogonial environment during recovery from the initial treatment cycle may drive an …
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Analysis of the role of the X/Y homologous gene family Xmr/Sly in murine spermiogenesis
… highly differentiated haploid sperm from diploid spermatogonial stem cells. Deletion analysis has established that genes on the Y chromosome are essential for normal sperm production in humans, mice and Drosophila. In mice, deletions of the Y chromosome long arm (Yq) are associated with abnormal …
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Characterization of germ cell development in free-living and parasitic flatworms
… correct specification and maintenance of germ cells for species survival. Germ cells must be carefully protected from inappropriate differentiation while simultaneously maintaining their identity as highly specialized totipotent cells. Several germ cell-intrinsic mechanisms, including …
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Cloning of medaka glial cell-derived neurotrophic factor (GDNF) and its receptor GFR alpha 1
Glial cell line-derived neurotrophic factor (GDNF) signaling through its receptor GFRI?1 plays an important role in many biological processes including cell survival, proliferation and differentiation. The aim of this project was to isolate and characterize both Gdnf and GfrI?1 from the medaka fish …
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Zur Pluripotenz Spermatogonialer Stammzelllinien
Spermatogoniale Stammzelllinien aus isolierten und kultivierten spermatogonialen Stammzellen aus Testis der adulten Maus sind pluripotent. Zur weiteren Untersuchung wurden die Zelllinien mit pluripotenten embryonalen Stammzelllinien der gleichen genetischen Hintergründe verglichen. Dabei wurde …
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Expression and functional analysis of <i>Tex18</i> and <i>Stra8</i> genes in male germ cells
Die vorliegende Arbeit befasst sich mit der Expression und der funktionellen Analyse der beiden Testis- spezifischen Gene Tex18 und Stra8. Die RT- PCR- Expressionsanalyse des Gens Tex18 zeigte eine Expression ausschließlich in männlichen Keimzellen. Außerdem konnte die Expression von Tex18 in …