Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Spermatogonia"”.
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The role of UCH-L1 in mouse progenitor spermatogonia
… throughout the life of the adult male, the spermatogonial stem cell (SSC) population of the testis needs to achieve a balance between self-renewal and differentiation. The chemical, molecular and physical environment that supports this balance of fate decision is not completely understood. …
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The Role of Stra8 in spermatogenesis : regulation of spermatogonial differentiation, meiotic initiation, and testicular tumor formation
… include the transition from undifferentiated spermatogonia to differentiating spermatogonia, which continue to proliferate mitotically, and the transition from mitosis to meiosis. This work led to questions about the mechanisms through which RA governs these transitions. Here I will present my …
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Kriptorchizmo chirurginio gydymo laikas ir vaisingumo prognozė vertinant spermatogenezę sėklidžių biopsijose /
… research analyzing the relationship between Ad spermatogonia in testicular biopsies and the patient’s age at orchopexy. The aim of the study was to estimate the most relevant time for surgical management of cryptorchidism. Ad spermatogonia have been chosen as a major histological factor …
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Coregulatory Transcription Factors and Spermatogenesis
… and CLD5 was expressed in both Sertoli cells and spermatogonia. Data presented here support the conclusion that Sertoli cell CLD5 has a role in BTB function, but also a non-tight junction role in spermatogonia.
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Multi-cycle cisplatin treatment alters spermatogonial functional stem cell behavior and niche
… permanent, infertility in men. Undifferentiated spermatogonia, including spermatogonial stem cells (SSCs), are theoretically capable of repopulating the seminiferous tubules after exposure has ceased. It is proposed that an altered spermatogonial environment during recovery from the initial …
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Mechanism of Spermatogonial Stem Cell Regulation by ETV2
… spermatozoa. Spermatogenesis is initiated from spermatogonial stem cells (SSCs) which self-renew or differentiate to give rise to differentiated progenies of germ cells. Hence understanding of SSC biology is essential to comprehend the complex process of spermatogenesis and has implications in …
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Pengaruh ekstrak daun beluntas (Pluchea indica Less) terhadap proses Spermatogenesis pada mencit (Mus musculus L)
… kontrol. Variabel yang diamati adalah jumlah sel spermatogonia, spermatosit primer, spermatid dan sel leydig. Data yang didapatkan di analisis dengan menggunakan ANOVA satu arah, bila dari hasil analisis diperoleh nilai Fhitung > Ftabel 1 % dilanjutkan dengan uji BNT dengan taraf signifikan 1%. …
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In vitro studies on genotoxicity and gene expression in spermatogenic cells: mechanisms and assay development
… of male germ cell development from diploid spermatogonia to haploid fertile spermatozoa. Apoptosis plays a vital role in limiting cell numbers and eliminating defective germ cells. This requires novel gene products, and precise and well-coordinated programmes of gene expression. It is …
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Gene expression changes during mammalian male meiotic initiation
… pure populations of undifferentiated Type A spermatogonia, Type B spermatogonia, STRA8- preleptotene spermatocytes, loSTRA8 preleptotene spermatocytes, hiSTRA8 preleptotene spermatocytes, and leptotene spermatocytes. Following transcriptome sequencing, data analysis showed several different …
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THE MECHANISTIC TARGET OF RAPAMYCIN (mTOR) AND ITS COMPLEX 1 ASSOCIATED PROTEIN RPTOR ARE GERM CELL-AUTONOMOUSLY REQUIRED FOR SPERMATOGONIAL DEVELOPMENT & CHAPTER IV: INVESTIGATING CHANGES IN THE TESTICULAR TRANSCRIPTOME DURING THE PROSPERMATOGONIAL TRANSITION
Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis, and they provide the foundation for spermatogenesis and life-long fertility. Currently, the factors that regulate these varying spermatogonial fates, in particular the molecular mediators that regulate …
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The Role of Differential Sensitivity to Retinoic Acid (RA) in Regulating Spermatogonial Fate
… the foundation of spermatogenesis is provided by spermatogonial stem cells (SSCs); their progeny either remain as stem cells (following a self-renewal division) or proliferate as undifferentiated progenitors prior to differentiating in response to retinoic acid (RA) and later entering meiosis. The …
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Seasonal Reproductive Changes in Cryptobranchus Alleganiensis
… October. The testes had regressed by October. Spermatogonia occupied the regressed testes from October through June. Vitellogenic activity was greatest from May through mid-September. Absolute and relative ovarian weights and ovarian oocyte diameters were maximal during September prior to …
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INVESTIGATING MECHANISMS REGULATING MAMMALIAN SPERMATOGONIAL DIFFERENTIATION AND MEIOTIC INITIATION
Spermatogonia differentiation and meiotic initiation are complex processes essential for male fertility. Despite knowing for nearly 60 years that retinoic acid (RA) is instrumental for successful production of functional sperm, molecular mediators that regulate spermatogonial differentiation and …
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DEVELOPMENT OF NOVEL BIOTECHNOLOGICAL APPROACHES FOR ACCELERATING GENETIC GAIN IN THE BOVINE
… the differentiation of embryonic cells into the spermatogonial lineage and to subsequently support their progression through complete meiosis. The initial experiments aimed to establish a protocol for isolating immature bovine spermatids and evaluating their fertilization potential using …
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Curbing environmental pollution of water hyacinth by using it in drug discovery
… and the effect of the most potent extract on spermatogonia stem cell viability.<br/><br/>We describe, for the first time the bioactive compound profile of water hyacinth samples from Adamawa state Nigeria and its antioxidant capacity using GC-MS and ABTS free radical inhibition assay. Using …
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Role of GnIH and GnRH in Paracrine Control of Gametogenesis in Zebrafish (Danio rerio)
… and changes the proliferative activity of spermatogonia cells. It was also found that zGnIH at all concentrations tested inhibits both human chorionic gonadotropin hormone (hCG) and follicle-stimulating hormone (FSH)-induced spermatogenesis. With respect to GnRH peptides, both native …
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Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
Spermatogonial stem cells (SSCs), as the foundation for spermatogenesis, must maintain a balance of both self-renewal and differentiation. Although several factors important for these processes have been identified, the fundamental mechanisms regulating SSC self-renewal and differentiation remain …
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Localization of nerve growth factor-β in the stallion reproductive tract
… was noted in Leydig cells, Sertoli cells and spermatogonia within the testes and in epithelial cells of the epididymis. In conclusion, immunohistochemistry revealed that NGF-β is present in the stallion reproductive tract and the protein is primarily present in the efferent ducts of the testes …
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Organ and primary culture of medaka (Oryzias latipes) testis: Test systems for the analysis of cell proliferation and differentiation
… criteria, the proliferating cells were mostly spermatogonia and possibly also preleptotene spermatocytes. Differentiation of spermatocytes into spermatids or spermatozoa was also observed, mainly among the suspended cells. These results suggest that the organ and primary culture systems are …
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A Mutation in Alk6b Causes Impaired Germ Cell Differentation and Testicular Germ Cell Tumors in Zebrafish
… develop tumors consisting of undifferentiated spermatogonia by 4 months of age while heterozygous males develop tumors around 7 to 9 months of age. We used interval haplotype analysis and high-resolution recombinational mapping to localize the mutation to a 0.82 cM interval on zebrafish …
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