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Showing 1 to 4 of 4 for “"Spemann organizer"”.
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A role for the Spemann organizer gene, Goosecoid, in tumor metastasis
… that genes controlling cellular changes in the Spemann organizer at gastrulation might be reactivated in tumors. The Goosecoid homeobox transcription factor is a known executer of cell migration from the Spemann organizer. I found that indeed Goosecoid is overexpressed in a majority of human …
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Transcriptional Integration of Wnt and Nodal Signals in the Establishment of the Spemann Organizer
… body axis requires the formation of the organizer domain during early embryogenesis. In amphibians, this domain is referred to as the Spemann Organizer and is essential for germ layer patterning and formation of the embryonic body axes. The Wnt and Nodal signaling pathways are both …
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Casein Kinase I Transduces WNT Signals
… zone in Xenopus, inducing markers of the Spemann organizer which is a product of Wnt signaling. We next investigated the ability of CKI inhibitors to block Wnt signaling in vivo. Two dominant negative forms of CKI and a specific pharmacological inhibitor of CKI all blocked the ability of …
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Establishment of retinoic acid gradients in the early development of Xenopus laevis
Retinsäure (RA) ist ein wichtiges Morphogen, das viele biologische Prozesse reguliert, einschließlich der Entwicklung des zentralen Nervensystems (ZNS). Die Synthese von RA aus Vitamin A (Retinol) läuft in zwei Schritten ab, wobei die zweite Reaktion- katalysiert von Retinal-Dehydrogenasen …