Global ETD Search
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Showing 1 to 3 of 3 for “"Spectinamide 1599"”.
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PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations. and the Identification of Potential Partners for Combination Therapy
… and are thought to prolong TB pharmacotherapy. Spectinamide 1599 is a synthetic modification of spectinomycin that has demonstrated excellent preclinical drug like properties such as excellent in vivo efficacy, strong efficacy against clinical MDR isolates, lack of cross resistance, long post …
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Model-Based Dose-Exposure-Response Assessment for Lead and Backup Spectinamide in a Mouse Model of Tuberculosis
… under investigation, the semisynthetic compounds spectinamides are a promising novel class of anti-tuberculosis agents. One such lead candidate, spectinamide 1810, and backup spectinamide 1599 have demonstrated excellent efficacy, safety, and drug-like properties in various in vitro and in vivo …
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Physiologically-Based Pharmacokinetic (PBPK) Modeling for the Preclinical Development of Spectinamide Antibiotics
… the treatment of MDR or XDR TB infection. Spectinamide 1599 and spectinamide 1810 are lead spectinamide compounds currently under preclinical development for the treatment of MDR and XDR tuberculosis. These compounds have previously been tested at various combinations of dose level, dosing …