Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3895 for “"Specificity"”.
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Cadherin recognition and specificity
… mediated cell-cell interaction and binding specificity. First, the bond properties were studied with the micropipette manipulation method. The results revealed that cadherin binding exhibits biphasic kinetics. Further studies with domain deletion mutants showed that the EC1 domain of …
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Redesigning specificity in miniproteins
… features, such as folding and interaction specificity, in natural proteins. A 21-residue [beta][beta][alpha] homotetramer miniprotein (BBA) was computationally redesigned to interact as a heterotetramer. Protein design calculations revealed a large/small pattern of hydrophobic residues in …
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Determinants of antibody specificity
… including antibody aggregation and nonspecificity, can lead to problems during production and poor pharmacokinetics (PK). The exact structural and sequence determinants causing this poor developability are unknown, which leads to inexact methods to correct otherwise promising clinical …
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Specificity of triple helix formation
… to the end of a TFO to increase stability. The specificity of five<br/>TFOs with different anthraquinone modifications was examined by footprinting<br/>against fragments containing mismatches. A doubly modified TFO bound with the<br/>highest affinity and was most tolerant of mismatches. …
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Visualizing Synaptic Specificity with GRASP
… facilitate deeper understanding of synaptic specificity. In this thesis, I describe the development of a method, GFP reconstitution across synaptic partners (GRASP), that allows visualization of defined synapses in vivo, and apply this method at one set of synapses in the brain of the …
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WIP1 Phage Specificity for B. Anthracis
… may be a superior diagnostic tool. Wip1's high specificity to B. anthracis is likely mediated by the initial recognition and binding of the virus to the host cell. Most bacteriophages interact with bacterial surfaces using tail fibers, but Wip1 is a tailless phage possessing an icosahedral …
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SNARE specificity in membrane protein traffic
Recent findings indicate that there is a role for SNAREs in ion channel regulation. With the discovery of the vesicle trafficking SNARE protein NtSYP121 came the development of the predicted cytosolic domain fragment of the protein. This Sp2 fragment was found in studies to block the responses of …
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Digital Fabrication for Contemporary Material Specificity
… design tools. Contemporary notions of material specificity, such as DeLanda’s “possibility space” and McDonough and Braungart’s Circular Economy, attempt to reject logical positivism by identifying the contingent factors, or “events,” across a material’s life that must be designed for, such as …
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Cadherin specificity in adhesion and mechanotransduction
Cadherins mediate Ca2+ dependent cell-cell junction in all animal tissues. Tight regulation of cadherin adhesion plays critical roles in diverse biological processes. Differential binding between cadherin subtypes is widely believed to mediate cell sorting during embryogenesis. However, a …
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The evolution of protein kinase specificity
… only a restricted set of substrates. This specificity is achieved partly by contextual factors that separate kinases spatially and temporally, but also by sequence features that are encoded in the kinase domain itself. For this thesis I focus on elements of kinase specificity that are …
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The impact of asset specificity on outsourcing performance : a disaggregated analysis by buyer-supplier asset specificity dimensions
lthough much research has been done on both asset specificity and outsourcing performance, most of the former has focused on the question of governance choice, while the latter has mainly concentrated on the skills required in managing the buyer-supplier relationship, leaving a glaring gap on the …
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Levels of asset specificity in relational contracting
… this assumption is in place, the level of asset specificity has no bearing on the make-or-buy decision. While there are good reasons to doubt the universality of transaction cost economics’ prediction that the more specific the asset, the more likely is vertical integration to be optimal, this is …
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Synaptic Specificity in the Zebrafish Lateral Line
… necessary models for understanding how synaptic specificity arises. The posterior lateral-line organ of larval zebrafish consists of polarized hair cells organized in discrete clusters known as neuromasts. Here I show that each afferent neuron of the posterior lateral line establishes specific …
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Human Capital Specificity and Corporate Capital Structure
… as an exogenous reduction in human capital specificity-- the inability to transfer specific skill sets across employers--for incumbent workers in a local labor market. My results indicate that the opening of a new manufacturing plant in a given county leads to a 2.6-3.9% increase in the …
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Junction Specificity and Transmembrane Linkages of Integrins
We have also isolated a monoclonal antibody, P4B2, which localizes to multiple adhesion junctions, namely, a subset of focal adhesions, the Z-disc of muscle, and neuromuscular junctions. Immunopurification of the antigen to this antibody from chicken brain tissue yielded a complex of three …
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Specificity and Properties of a Bacteriolytic Enzyme
Made available in DSpace on 2014-12-09T22:04:16Z (GMT). No. of bitstreams: 1 6801777.pdf: 2811725 bytes, checksum: 80693b41fa6f9f04b356f931ef68e513 (MD5) Previous issue date: 1967
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Deciphering protein binding specificity with deep learning
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Specificity and agreement in standard Western Armenian
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 1997.
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The evolution and specificity of RNA splicing
The majority of human genes are not encoded in contiguous segments in the genome but are rather punctuated by long interruptions known as introns. These introns are copied from generation to generation, and even from cell to cell as a person grows from an embryo into an adult. Each time a gene is …
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