Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 227 for “"Specific Expression"”.
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Visualizing Allele Specific Expression In Single Cells
… have enabled the quantification of gene expression at the single cell level, revealing significant variability that has been previously obscured by techniques measuring population averages. These techniques, however, have been limited in that they cannot classify transcripts according to …
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Microspore-specific expression of a gene from tobacco
Contains fulltext : mmubn000001_246032790.pdf (Publisher’s version ) (Open Access)
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Control of M-G1 phase-specific expression in fission yeast
… number of eukaryotic genes that are expressed at specific cell cycle times. Certain genes are cell cycle regulated in a number of organisms, suggesting that their phase-specific transcription is important for all eukaryotic cells. The budding and fission yeasts, Saccharomyces cerevisiae and …
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
… to enable examination of ACE mRNA and protein expression during enzyme inhibition with enalapril. Rat lung ACE mRNA increased by 156% (p<0.05) and ACE protein doubled within 3 hours of administering a single dose of enalapril. Testicular ACE mRNA also increased by 300% (p<0.05) within 2 hours …
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Isoform-Specific Expression During Embryo Development in Arabidopsis and Soybean
… identify transcriptional changes associated with specific stages of embryo development and infer possible associations between known regulatory genes and their targets. We identified several instances of exon skipping and intron retention as products of alternative splicing. The coding potential …
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Caste-Specific Expression Of Coding And Noncoding Genes In Ant Brains
… broadly defined as heritable changes in gene expression independent of changes to the DNA sequence itself, is tightly associated with how one genome can give rise to multiple phenotypes. Social insects are an ideal model system for epigenetics, as their colonies contain individuals with highly …
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Elucidation of the regulatory mechanism of SWEET11 phloem parenchyma cell-specific expression
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Tissue- and Development-specific Expression of Proton-mediated Peptide Transporters in the Developing Chicken
… study was to profile PepT1, PepT2 and PHT1 mRNA expression in the proventriculus, duodenum, jejunum, ileum, ceca, large intestine, brain, heart, bursa of Fabricius, lung, kidney, and liver in layer chicks on embryonic days 18 and 20 and days 1, 3, 7, 10, and 14 post-hatch. Absolute quantification …
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Identification and Characterization of Transcriptional Regulatory Elements for Liver-Specific Expression of Rabbit CYP2C Genes
… is the largest family with a predominant liver-specific expression pattern. We have developed a functional analysis system using rabbit CYP2C 5$\sp\prime$ flanking region-luciferase chimeric constructs to transiently transfect hepatoma cells (HepG2) and demonstrated the presence of multiple …
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Region-Specific Expression of Brain-Derived Neurotrophic Factor (BDNF) mRNA after Long Term Treatment with Lithium Carbonate.
… to determine if lithium ion would regulate expression of BDNF for its anti-apoptosis action. RT-PCR and fluorescence in situ hybridization experiments were performed to determine the lithium-sensitive expression profile in brain and spinal cord. In the brain, chronic treatment with lithium …
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Sex-specific expression of CYP2C2 in transgenic mice and phenobarbital regulation of CYP2B by in situ injection
… intestine, or heart, similar to the tissue-specific pattern of this gene in rabbits. Unlike expression in rabbits, the transgene was expressed in a male-specific pattern in liver and kidney, and was undetectable in the female. Expression in the male mice was repressed after castration, while …
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MicroRNAs in ALS: Defining Cell-Type Specific Expression, Developing Methods to Modulate MicroRNAs in vivo, and Identifying Novel Therapeutic Targets
… that this newly discovered class of gene expression repressors may be viable therapeutic targets. A microarray of miRNA changes in ALS model SOD1G93A rodents identified 12 miRNAs as significantly changed. Six miRNAs tested in human ALS tissues were confirmed increased. Specifically, …
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Tissue-Specific Expression and Steroid Hormone Regulation of Human Gonadotropin -Releasing Hormone (hGnRH) Gene in Placental Cells (JEG -3 cells)
… I investigated the mechanisms behind the tissue-specific expression and steroid hormone regulation of the hGnRH gene in the human placenta. The hGnRH upstream promoter was found to be functionally active in JEG-3 cells. The DNA sequence responsible for functioning of the upstream promoter in …
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Malignant hyperthermia: allele specific expression and mutation screening of the ryanodine receptor 1 : a dissertation presented to Massey University in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry
… muscle calcium release channel (RyR1). Allele-specific differences in RyR1 expression levels might provide insight into the observed incomplete penetrance and variations in MH phenotypes between individuals. Firstly, an H4833Y allele-specific PCR (AS-PCR) assay was designed that allowed for the …
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Analysis of organ-specific gene expression in soybean
Organ specificity is an important criterion to be considered for the expression of foreign genes in plants. For crop improvement by genetic engineering it is critical to introduce genes in specific organs that can be expressed at an appropriate developmental stage. This study involved the analysis …
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An Investigation Into Splicing Variation and Expression Patterns of Insulin-Like Peptide 4 (ILP4) Within the Drosophila Genus
… identified is significant variation in sex specific ILP4 expression patterns across the Drosophila genus. Future research is called for to explore tissue-specific expression and the observed functional consequences of sequence variations. By investigating this splicing variation and …
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3D Chromatin Structure and Gene Regulation: Integrated Genome Structure, Transcriptomics and Epigenetics
… of the genome is essential for regulating gene expression, replication, and stability. Chromatin folding mediates enhancer–promoter communication, but bulk Hi-C data obscure single-cell variability, while sparse single-cell Hi-C limits structural resolution. This dissertation develops …
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Targeting tGLI1-positive Breast Cancer with Ketoconazole
… GLI1 transcription factor and demonstrates tumor-specific expression. Previous results in our laboratory have implicated tGLI1 in promoting breast cancer stem cells (CSCs) and BCBM. These potent oncogenic and metastasis-promoting effects and tumor-specific expression make tGLI1 an ideal …
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Characterization of an aryl hydrocarbon receptor from a cetacean : an approach for assessing contaminant susceptibility in protected species
… and function are known to contribute to species-specific differences in susceptibility to HAH toxicity, and targets for HAH toxicity are related to the tissue-specific expression of AHR. The goal of these studies was to ascertain the potential for HAH effects in cetaceans by characterizing the …
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Zur Transkriptions- und Translationskontrolle des Gens für Transitionsprotein
… which could direct the testis- and haploid-stage specific expression of the Tnp2 gene, a region of -74 to +70 was alyzed in transgenic mice. Earlier results revealed that a 565 bp 5"UTR can direct tissue- and ime-specific expression of Tnp2 gene in transgenic mice. The region was shortened to 147 …
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