Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Species Barrier"”.
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Deciphering the Molecular Basis of the Species Barrier in Prion Disease Using Bank Vole PrP
… the two molecules. PrPC and PrPSc from different species do not share an identical amino acid sequence and therefore are often not structurally compatible for efficient templated misfolding, a phenomenon referred to as the species barrier. Bank vole (Bv) PrP is an exception, as it serves as an …
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Structural Basis of Bat and Raccoon Dog Angiotensin-Converting Enzyme 2 (ACE2) Receptor Recognition by Sarbecoviruses
… the mechanisms that facilitate cross-species transmission into human populations is essential for elucidating the evolutionary origins and pandemic potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This dissertation investigates the molecular basis of receptor …
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[GAR⁺] : a novel type of prion involved in glucose signaling and environmental sensing in S. cerevisiae
… [GAR⁺] propagation is subject to a strong species barrier, as substitution of PMAl from other Saccharomyces species blocks propagation to s.. cerevisiae PMAl. Direct competition between [gar-] and [GAR⁺] cells indicate that cells carrying [GAR⁺] have an advantage under certain environmental …
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Labordiagnostische Referenzbereiche bei unterschiedlichen Schweinerassen sowie histopathologische und immunhistochemische Untersuchung von Gehirnen älterer Sauen und Eber auf transmissible spongiforme Enzephalopathie im Rahmen der TSE-Studie
… from cattle. This means that, in spite of the species-barrier, even though the infection was transmitted parenterally, pigs, along with many other animals, are susceptible to an infection with the bse-agent. There is a definite need for acquiring further knowledge on the exact onset of and …
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The role of buried stack residues in the folding of the beta-helix domain of P22 tailspike
… of amyloid fibers or the sequence-dependent species barrier to amyloid transmission. Side chain stacking has long been observed as a prominent feature of the soluble parallel [beta]-helix fold, which exhibits a cross-[beta] structure reminiscent of amyloids. To investigate the sequence …
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Interaction studies of the cellular prion protein
… protein (PrP) which is well conserved among the species. In this thesis the biochemical properties and the function of prion protein were investiagted using different methods. The oligomerisation state of the prion protein analysed by size exclusion chromatography revealed that the prion protein …
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The genomic basis of species barriers in Heliconius butterflies
… process of speciation. Hybridization between two species is often maladaptive and results in offspring with decreased fitness compared to the parental forms. Recently, with the development of molecular and genomic tools, it has become possible to understand how and when reproductive isolation …
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Molecular and Serological Epidemiology of Swine Hepatitis E Virus from Pigs in Two Countries
… the United States and has the ability to cross species barrier and infect humans. There are four major genotypes of HEV worldwide and swine HEV identified to date in different countries belongs to either genotypes 3 or 4. Thus far, genotypes 1 (Asian strains) and 2 (a single Mexican strain) of …
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Factors influencing pyrethroid barrier spray effectiveness against Aedes mosquitoes
… of Ae. albopictus. Because it is a diurnal species, standard mosquito control efforts utilizing spray trucks or planes to administer insecticides offer little control, as these methods are directed towards crepuscular species. Barrier spray applications, however, have been shown to achieve a …
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Meccanismi evolutivi dei parapoxvirus: caratterizzazione genomica di pseudocowpoxvirus e messa a punto di sistemi per lo studio delle ricombinazioni
… DNA (dsDNA) viruses that cause disease in many species, both vertebrate and invertebrate. Their genomes range in size from 135 to 365 kbp and show conservation in both organization and content. In particular, the central genomic regions of the chordopoxvirus subfamily (those capable of infecting …
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Influence of CO2 on fishes in flowing water environments: implications for a non-physical barrier to movement
… and bighead carp (H. nobilis) are invasive species that have become established in the upper reaches of the Illinois River, and are nearing the connection into Lake Michigan. To prevent the spread of these carp, as well as other fish, carbon dioxide (CO2) is being investigated as a potential …