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Showing 1 to 18 of 18 for “"Specialized metabolites"”.
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Investigation of Specialized Metabolites in Apicomplexan Parasite Life Cycles
<p>Across the tree of life, specialized metabolites mediate ecological interactions and can ultimately drive evolution. Characterization of these small molecules have led scientists to a greater comprehension of ecological niches at the macro- and micro-scale. A group of medicinally important …
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Characterization of six Arabidopsis AROGENATE DEHYDRATASE promoters
… plants, and is a major component of numerous specialized metabolites including structural components, pigments, and defense compounds. The last step in the synthesis of phenylalanine is catalyzed by an enzyme called AROGENATE DEHYDRATASE, of which there are six different isoenzymes encoded by …
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Investigations into the molecular evolution of plant terpene, alkaloid, and urushiol biosynthetic enzymes
… chemicals (so called secondary or specialized metabolites) that confer a selective advantage to the plant, such as defense against herbivory or protection from changing environmental conditions. Many of these specialized metabolites are used for their medicinal properties, as lead …
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The Origins of Terpene Infochemicals in Insects: Identification and Evolutionary Analysis of Terpene Synthases in Diverse Lineages
Specialized metabolites have important roles as infochemicals in inter- and intraspecific interactions of insects. A particularly abundant class of specialized metabolites are terpenes, which are released by many members of taxonomically diverse insect lineages as pheromone and defense compounds. …
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Natural product chemistry in drug discovery
… and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three publications. The first is a literature review of structure-dependent activity among …
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Enzyme structure, function, and evolution in flavonoid biosynthesis
Plant specialized metabolism is a key evolutionary adaptation that has enabled plants to migrate from water onto land and subsequently spread throughout terrestrial environments. Flavonoids are one particularly important class of plant specialized metabolites, playing a wide variety of roles in …
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A small molecule-guided structure-function exploration of mitochondrial aldehyde dehydrogenase
… activity of plants is often derived from specialized metabolites, also called natural products. Despite this wealth of medical tradition, modern medicine was unable to precisely characterize the wealth of chemistry and individual bioactivities locked in whole plant tissues until recently. …
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Metabolomic approaches to understanding the auxin and ethylene response in Arabidopsis roots
… through alterations in the levels of flavonoids, specialized plant metabolites that have been shown to act as negative regulators of auxin transport. However, much remains to be learned about auxin and ethylene responses at the level of the metabolome. LC-MS analysis showed that a number of ions …
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Cell-type specificity and herbivore-induced responses of primary and terpene secondary metabolism in Arabidopsis roots
… barriers or use chemical compounds such as specialized secondary metabolites to resist herbivore or pathogen invasion. Considering the cost-efficiency and energy balance between defense, growth and reproduction, defense reactions in plants have to be regulated temporally and spatially. As …
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Investigations into the Phage-Host Dynamics of Streptomyces
… and prodigious production of secondary or specialized metabolites, chemicals that help them compete against other microbes sharing their environment. Here, I show that Streptomyces utilize secondary metabolites to protect their communities against phage infection. In particular, DNA …
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Proteomic Analysis of the Flavonoid Biosynthetic Machinery in Arabidopsis Thaliana
… complexes at the cellular level. Flavonoids are specialized metabolites that perform many important physiological roles in plants. Protein interactions among several key flavonoid enzymes have been described. Moreover, at least two of the flavonoid enzymes have a dual cytoplasmic/nuclear …
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Expanding the Role of Oxidoreductases in Benzylisoquinoline Alkaloid Metabolism in Opium Poppy
… a large and structurally diverse group of plant specialized metabolites with several possessing pharmacological properties including the analgesic morphine, the cough suppressant codeine, and the vasodilator papaverine. In opium poppy, the antepenultimate and final steps in morphine biosynthesis …
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Biochemical, Molecular and Functional Analysis of Volatile Terpene Formation in Arabidopsis Roots
Plants produce secondary (or specialized) metabolites to respond to a variety of environmental changes and threats. Especially, volatile compounds released by plants facilitate short and long distance interaction with both beneficial and harmful organisms. Comparatively little is known about the …
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Chemophenetics of selected European plant taxa
Diese Dissertation untersucht die chemische Diversität ausgewählter europäischer Pflanzen aus einer chemophänetischen Perspektive. In vier komplementären Studien werden Metabolitprofile mit taxonomischen Beziehungen, saisonalen Veränderungen und post-harvest Prozessen verknüpft. Vergleichende …
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Identification, Characterization, and Functional Analysis of Terpenoid Specialized Metabolism in Switchgrass (Panicum virgatum) and Carrot (Daucus carota)
Plants produce a large number of specialized or secondary compounds that aid in their reproduction and protection against biotic and abiotic stress. In this work I investigated the metabolism and function of terpenes, the largest class of specialized metabolites, in switchgrass and carrot. …
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Pheromones, nectar, and computer vision: investigating large-scale patterns of chemodiversity.
… diversity across taxa, ecological functions of specialized chemistry in plant - pollinator interactions, and methods of automating data collection for monitoring insect diversity. In particular, I investigate the role of specialized nectar chemistry under several existing hypotheses, generate …
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Paralogous genes in Arabidopsis thaliana contribute to diversified phenylpropanoid metabolism
… provides added fitness remains difficult. Plant specialized metabolism provides an attractive platform to study the fixation of genes post duplication and how this process leads to the chemical diversity seen today. Specialized metabolites by definition are thought to be dispensable under normal …