Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Spatial light interference microscopy (SLIM)"”.
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Spatial light interference microscopy (slim) measurements of hypothermia in an experimental cellular model of traumatic brain injury
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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Engineered hydrogels for tracking cell signaling from the outside-in
… we combine our polyacrylamide model system with spatial light interference microscopy (SLIM) in order to design a novel patterning approach to simultaneously measure cell traction force along with cell growth and migration. This allows us to study the interaction between cells and ECM to …
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miR-125b toggles dynamics and structure of dendritic filopodia in developing hippocampal neurons
… with maintaining filopodial morphology. Using Spatial Light Interference Microscopy (SLIM), we show that miR-125b function contributes to maintaining the dynamicity of filopodia. We propose that miR-125b is critical in maintaining the filopodial phenotype early in dendrite development, thus …
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Spatial light interference microscopy and applications
Phase contrast microscopy has revolutionized cell biology by rendering detailed images from within live cells without using exogenous contrast agents. However, the information about the optical thickness (or phase) is qualitatively mixed in the phase contrast intensity map. Quantifying optical …
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Quantitative phase imaging: advances to 3D imaging and applications to neuroscience
… applications and advances made on them. First, spatial light interference microscopy (SLIM) is introduced as a QPI method extensively used in this thesis. Using this setup, an application of QPI in neuroscience is demonstrated by studying the emergent formation of a neuronal network. Second, an …
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Neuronal filopodia borne along tips and shafts of dendrites comprise two distinct populations as evidenced by differences in structure and dynamics
… and into synaptogenesis, brought into the spotlight their putative precursors – the dendritic filopodia. This set off several lines of investigation into filopodial structure and function, notable among which is the work by Portera-Cailliau et al. who showed in 2003 that growth cone filopodia …
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Quantitative light imaging of intracelluar transport
… traffic patterns using a new application of spatial light interference microscopy (SLIM) (Chapter 1). We used this quantitative phase imaging method to measure the dispersion relation, i.e. decay rate vs. spatial mode, associated with mass transport in live cells. This approach, …
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Redox manipulation alters hippocampal neuron response to semaphorin 3A
… the initial effects of the treatments using spatial light interference microscopy (SLIM) in real time. The effects of reducing conditions on dendritic growth was consistent with the initial hypothesis but the effects of oxidizing conditions revealed a more complex relationship between Sema3A …
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Label-free breast histopathology using quantitative phase imaging
… phase imaging (QPI). QPI is a label-free microscopy technique where image contrast is generated by measuring the optical path-length difference (OPD) across the specimen. OPD refers to the product of the refractive index and thickness at a point in the field of view. Since this measurement …
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Using CRISPR/Cas9 to modify the genome of cattle
… and pictures taken of the sperm using the Spatial Light Interference Microscopy (SLIM) confirmed the presence of liposomes on the sperm head and tail. SMGT was then used with IVF to deliver two plasmids containing GFP encoding region under the control of CMV promoter; pIRES2-EGFP and …
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Prostate tissue diagnosis using quantitative phase imaging techniques
Restriction data tranferred 2014-07-01T11:20:34-05:00 Original Data Group with Access UIUC Users [automated] Release Date: 2015-08-22 11:49:27 UTC Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system
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High throughput platform for multiscale quantitative phase imaging
Quantitative phase imaging (QPI) yields the spatial phase map of the object’s scattering potential. QPI has enabled unprecedented label-free studies in biomedicine, ranging from cell dynamics and growth to cancer diagnosis and prognosis. The field is currently transitioning from technology-driven …