Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Spatial genomics"”.
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Decoding Breast Cancer Development Through Single Cell and Spatial Genomics
… and progression, we performed single-cell and spatial profiling of DCIS and IDC tissues. To overcome key limitations in spatial analysis, we first developed a computational tool, CellTrek, that directly maps single cells onto tissue sections. Applying CellTrek to DCIS samples, we found distinct …
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Cancer Cartography: Mapping Cancer Evolution in Tissue Space
… tumour microenvironment (TME) and the impact of spatial constraints on cancer evolution. Emerging spatial omics technologies offer the potential to address these gaps, although their application in spatial genomics remains limited. This is particularly crucial because genetic alterations not only …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… epithelial cancer cells as demonstrated by spatial genomics. LAR and LAR-AR-SV TNBC cell proliferation, orthotopic cell line and patient-derived xenograft, and patient-derived tumor explants growth were inhibited by AR N-terminal domain (NTD)-binding selective AR degrader (SARD) that …
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Probabilistic models to resolve cell identity and tissue architecture
… of these processes using single-cell and spatial genomic data. Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in health and disease, but comprehensive mapping of cell types in situ remains a challenge. I present cell2location, a Bayesian model …