Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Spatial genome"”.
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Sculpting 3d Chromatin Folding Via Genome Editing
… inserts revealed their distinct contributions to genome folding. Altogether, short DNA insertions can suffice to shape the spatial genome in a manner influenced by chromatin context. Additionally, we frame our findings in the context of recent advances in experimentally creating chromatin loops, …
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Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
… a crucial role in transcriptional repression and genome stability. However, the molecular mechanisms that tether LADs in human cells remain poorly defined. To address this gap, I conducted the first genome-wide, imaging-based siRNA screen to identify regulators of LAD positioning using HiDRO …
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Scalable Methods for In Situ Genomics
… remains challenging, and accordingly the role of genome structure and organization in determining cellular function is an open question. Mapping cellular genome organization is difficult because it requires joint measurement of linear DNA sequence and 3D spatial context, however, existing …
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Genomic and microscopic dissection of nuclear compartmentalization and function
The spatial genome organization in the cell nucleus is non-random and important for gene expression regulation. Abnormal nuclear organization is related to disease. Microscopy measurements of individual genes reveal a population-based, statistical gradient of increased gene activity from the …
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The interplay of global chromosomal organisation, promoter-enhancer interactions and transcription
… cell types have led to the identification of spatial genomic structures, including Topologically Associating Domains (TADs). In parallel, high-resolution versions of these technologies (such as 5C, CHiA-PET, HiChIP and Capture Hi-C) have detected multitudes of novel looping interactions, …