Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 48 for “"Spatial Organisation"”.
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Spatial organisation of proto-oncogenes in human haematopoietic progenitor cells
… sequencing to determine genomic regions that spatially co-associate with the proto-oncogenes MLL, ABL1 and BCR. In addition to further developing the laboratory protocol, I have created bioinformatics tools used in the analysis of the sequencing data. I find that the association profiles of …
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Clonal deconvolution of transcriptomic signatures and their spatial organisation in a mouse model of breast cancer
… mapping clonal and transcriptional identities spatially. Collectively, this thesis contributes to the characterisation and understanding of breast cancer heterogeneity and the impact of clonal architecture on tumour progression and response to therapy.
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Mapping the spatial organisation of B cells and immune signalling in TNBC to characterise response to immunotherapy
… cancers. B cells exist in various states of spatial organisation within the tumour microenvironment (TME), which likely support many of their functional roles. However, the landscape of B cell spatial organisation in cancer and specifically in triple-negative breast cancer (TNBC) is poorly …
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Spatial organisation of the immunoglobulin heavy chain locus and inter-chromosomal gene networks driving B cell development
… of the antibody. Gene expression depends on spatial organisation of chromatin. To ensure that all V genes have a chance to recombine, they are brought into physical proximity to the D-J region by locus contraction and DNA looping. Not all V genes recombine with equal frequencies and we aim to …
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Physical Space in Retail Digitalisation: An Investigation into How Experiential Consumption and Spatial Organisation is Reconfiguring the Retail Value Chain
… on this framework, the research investigates the organisational change of consumption sites with the digitalised retail value chain. This study draws on a critical realist approach on organisational change, to identify emergent and potential mechanisms for retail digitalisation in e-commerce …
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An investigation into the barriers to employment for unskilled workers in Site C, Khayelitsha and Du Noon, Milnerton : does spatial mismatch theory apply?
… policies and new development trends, the spatial organisation of Cape Town is dispersed and decentralised. Many disadvantaged communities, including Khayelitsha, lie on the peripheral part of the city in the south east sector, distant from job opportunities. The rate of unemployment in …
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Internationalisation of business clusters: the case of fruit processing clusters in Ghana
… propounded industrial clusters, the study of spatial organisation over the years has revealed numerous benefits of agglomeration to businesses, countries and regions. Until recently, discussions on the gains associated with internationalising clusters have mainly been situated within the …
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Pattern Formation During Extensive Cell Movements
… across the developing tissue, which impart spatial coordinates to individual cells. These coordinates then inform the cell of its respective fate, and hence a pattern of gene expression with spatial organisation is generated. This way of thinking about the problem of pattern formation has …
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Analyse de la répartition spatiale des restes fauniques du site éémien de Caours (Somme). Apport des systèmes d'information géographique.
… about the choice of this locality and the spatial organisation of Neanderthal. Then, spatial analysis using the Geographic Information System (GIS) appear to being a useful tool to answer it. We show the consequent availability of water, prey and tool raw material. Neanderthalians was …
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Transcription Factor Binding Dynamics and Spatial Co-localization In Human Genome
… however, the relationship between genome spatial organisation and transcription factor binding is not well studied. Using the recently available high resolution Hi-C contact map of human GM12878 lymphoblastoid cells, we investigated computationally the genome-wide spatial co-localization …
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The Production of Uneven Geographies: Environmental Hazard Exposure and Socioeconomic Inequality
… attention to the role of urban form and the spatial organisation of economic activity in determining differences in exposure and adaptive capacity. The second explores the transformation of urban space under the expansion of the digital economy, examining how platforms are reconfiguring the …
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Double-stranded RNA uptake in Caenorhabditis elegans
… between the different SID proteins. The spatial organisation of SID-2 is conserved across species, suggesting a role for the TGN in environmental RNA uptake. By combing small RNA and transcriptome profiling with developmental studies I identified a novel role for systemic RNAi in worm …
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Quantitative super-resolution imaging of cell polarity proteins using DNA-PAINT
Knowing the localisation and spatial organisation of proteins is crucial for understanding their function. The development of super-resolution imaging has improved our ability to garner this information, but counting individual molecules in densely-packed assemblies is still challenging. DNA-based …
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Investigating lymphatic vascular remodelling during postnatal mouse mammary gland morphogenesis.
… aims of this project were: 1. To investigate the spatial organisation of lymphatic vessels in the mouse mammary gland. 2. To investigate whether lymphatic vessels, like blood vessels and the mammary epithelial tree, are temporally remodelled during mouse mammary gland morphogenesis. 3. To define …
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Urban Water History of Shahjahanabad, Delhi (1639-1857): Situating Mughal Hydrology and Urbanism in the ‘Persianate World’
… element’, the thesis decodes patterns of socio-spatial organisation, religious engagements, and urbanism practices emerging from hydrological interactions. It presents infrastructural systems as cultural artefacts and explores contours of control, access, and use of ‘water’ in the capital region …
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Re-animating dead space: the dislocation and relocation of affordances in interdisciplinary performance environments
… the centre and periphery of personal experience; spatial organisation; and disassociation and reappropriation: there were six events with a focus upon the implication of these ideas and their evolution into each event. Following observation of a poststructural emphasis upon personal experience and …
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Gene discovery in Catharanthus roseus using virus induced gene silencing
… the vacuole and highlights the importance of the spatial organisation of the pathway in preventing secologanin derivatisation. Secondly silencing the expression of a tonoplast localised nitrate/peptide (NPF) transporter, CrNPF2.9, resulted in the 20-fold accumulation of strictosidine, suggesting …
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Tidally Induced Transport Dynamics in a Wadden Sea Tidal Basin and Its Changes Under Future Sea Level Rise Scenarios
… atmospheric forcing. These interactions create spatial structures of hydrodynamic connectivity that govern transport processes, ecological functioning, and the interpretation of long-term observations. However, the persistence of these structures under future sea level rise and changing wind …
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Washington, D.C. and the Idea of America: A reappraisal of the 1791 plan for the Nation’s Capital
… of its size and one of the first attempts at a spatial organisation of the nation’s political objectives. This thesis argues that Pierre L’Enfant’s 1791 plan for the city is a unique example of eighteenth-century speculative development, that assimilated dominant European garden and urban …
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