Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Spatial Omics"”.
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Experimental design and analysis for high-parameter spatial omics
… enabled high-parameter molecular measurements (“omics”) to progress from bulk data, averaged across entire tissues or organisms, to single-cell measurements, which enable exploration of the vast diversity between individual cells, to a new frontier, spatial omics, which enables rich molecular …
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Tracing RNA biography: in situ transcriptome profiling by novel spatial omics technologies
… and translation within individual cells across spatial and temporal dimensions. Therefore, it is critical to methodically delineate the spatially resolved post-transcriptional regulations within transcriptomes, studying these events at the single-cell and single-molecule level. This advantage is …
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Cancer Cartography: Mapping Cancer Evolution in Tissue Space
… tumour microenvironment (TME) and the impact of spatial constraints on cancer evolution. Emerging spatial omics technologies offer the potential to address these gaps, although their application in spatial genomics remains limited. This is particularly crucial because genetic alterations not only …
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Development of spatial and single-cell omics methods for biochemical profiling of the brain
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Scalable Subcellular Resolution Mapping of the Human Brain
… made toward characterizing cells through various omics approaches, and have established invaluable databases yielding new insights. However, we still lack technologies for mapping the connectivity as well as molecular details of individual cells in the human nervous system, at the microscopic …
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The role of recombinant human laminin-111 in adhesion-signaling and glycosylation in laminin-⍺2 deficient muscle
… need to develop therapeutics for LAMA2-CMD. Spatial proteomics analysis of LAMA2-CMD patient biopsies revealed altered biological processes including protein aggregation, oxidative stress, and dysregulated glycolysis. In the LAMA2-CMD mouse model, the dyW, spatial proteomics showed similar …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… remain unknown. Integrating multiplex imaging, spatial transcriptomics, spatial metabolomics, and single-cell profiling across human and mouse MASH-driven hepatocellular carcinoma, TLS were found to be structurally present but functionally immature, characterized by selective loss of plasma cell …