Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 141 for “"Sp1"”.
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Targeted Inhibition of Sp1 Transcription Factor and Anti-Angiogenesis of Human Pancreatic Cancer
<p>Transcription factor Specificity Protein 1(Sp1) is reported to be essential for vascular endothelial growth factor (VEGF) constitutive expression in human pancreatic adenocarcinoma. The definitive role of Sp1 in angiogenesis, the impact of anti-angiogenic therapy on the Sp1/ VEGF signaling and …
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Group IIB dimers: Spectroscopy of molecular cadmium and gain demonstration in molecular mercury
The $\rm B\sp1\Sigma\sbsp{u}{+}$ state of $\rm Cd\sb2,$ correlated with $\rm Cd(\sp1S)+Cd(5p\ \sp1P\sb1),$ was studied by laser excitation spectroscopy from the lowest metastable state, $\rm a\sp3\Pi\sb{g}.$ The excitation spectrum of the $\rm B\sp1\Sigma\sbsp{u}{+}\gets a\sp3\Pi\sb{g}$ transition …
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Count and Tree in Uniform NC(1)
… on the function algebras of $AC\sp0$ and $NC\sp1$ (in (9)), we prove the following results: (1) count is in uniform $NC\sp1.$ (2) The equivalence of tree and k-BRN. (3) Multiple addition is in uniform $TC\sp0.$ (4) tree is uniform $NC\sp1$ complete under $AC\sp0$ reduction. We also discuss …
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Assessment of a pond for oyster hatchery development in South Africa
… a man-made salt-water pond (saltwater pond 1 SP1) as a potential site for the development of an oyster hatchery in Velddrif, South Africa. Over the study period it was observed that the site was not suitable for oyster larvae culture due to the following factors: temperature spikes during the …
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High-resolution nuclear magnetic resonance studies of lipids and model membranes
… to the new applications of high resolution $\sp1$H and $\sp{13}$C ""magic angle sample spinning"" (MASS) nuclear magnetic resonance (NMR) techniques to the study of model and biological membranes. Since the resolution of $\sp1$H and $\sp{13}$C MASS NMR spectra from multilamella and …
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Water relations of simple sugar solutions and skim milk powder as studied by nuclear magnetic resonance spectroscopy
… of sugar concentration was monitored by $\sp1$H, $\sp2$H and $\sp1$H decoupled $\sp{17}$O NMR transverse relaxation rates (R$\sb2$). For all three nuclei, R$\sb2$ increased with increasing sugar concentration with different magnitude and different trends of increases. Comparison of $\sp1$H, …
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Identifizierung und funktionelle Analyse der humanen Xylosyltransferase I- und II-Promotoren
… sites for transcription factors of the AP-1 and Sp1 protein family were identified. Several site-directed mutagenesis experiments as well as electrophoretic mobility shift and supershift assays using specific antibodies were used to clearly identify the transcription factors involved. The …
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Chronic Hypoxia Induces Epigenetic Modifications in the Fetal Rat Heart
… methylation of CpG dinucleotides for two SP1 binding sites located at proximal region of the PKCε promoter. Previous studies using reporter gene assays concluded the region encompassing both SP1 binding sites played a significant role in the activity of PKCε promoter. Chromatin …
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The Application of 'Magic Angle' Sample Spinning NMR to the Study of Liquid Crystals and Membranes
… broadening interactions in both $\sp $C and $\sp1$H spectra of liquid crystals. Due to the special form of the $\sp1$H-$\sp1$H dipole Hamiltonian in liquid crystals, the interactions are inhomogeneous and slow MASS gives rise to a highly resolved spectrum with spinning sidebands. The chemical …
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Ο ρόλος του SMAD σηματοδοτικού μονοπατιού στις σπειραματονεφρίτιδες του ανθρώπου
… της έκφρασης των παραγόντων pSmad2/3, p300, Sp1, Smad7 και Ski (μορίων που συμμετέχουν στο Smad σηματοδοτικό μονοπάτι) σε νεφρικές βιοψίες ασθενών με ΣΝ και η ανίχνευση της δράσης τους όσον αφορά την παθογένεση και την εξέλιξη της νεφρικής βλάβης. Χρησιμοποιήθηκαν 157 βιοψίες ασθενών με ΣΝ …
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Regulation of the beta7 integrin gene in T cells: role of the MAPK signalling pathways
… of nuclear protein complexes to TGFBRR-1 and -2. Sp1 and Sp3 which mediate TGF-β1 signalling were shown to bind to an Sp1 cis-element encompassing nucleotide positions -67 to -60 within TGFBRR-2. The interaction of Sp1 with its cognate binding site was c-Jun dependent. In contrast, there was no …
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NMR study of the unfolding of ribonuclease A, and dynamical studies of liquids in confined geometries
… of RNase A has been studied by 1D and 2D $\sp1$H NMR spectroscopy, spin-lattice relaxation time measurements, and the pressure-jump hydrogen-exchange method. It was found that the pressure denatured states of RNase A display some characteristics of a molten globule, and all three …
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
… trends were evident. Characterization of Sp1 binding revealed that treatment with sodium arsenite could decrease Sp1 binding at two unique Sp1 sites in the human Ogg1 promoter. In summary, transcription factor Nrf2 is an important factor in the inducible regulation of Ogg1. Transcriptional …
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
… trends were evident. Characterization of Sp1 binding revealed that treatment with sodium arsenite could decrease Sp1 binding at two unique Sp1 sites in the human Ogg1 promoter. In summary, transcription factor Nrf2 is an important factor in the inducible regulation of Ogg1. Transcriptional …
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Investigating the Role of Stem-Loop 1 in the Assembly Process of HIV-1
… (CA) domain of Gag, from its precursor, CA-SP1, by the viral protease. Large deletions in stem-loop 1 (SL1) in the 5’ untranslated region (UTR) of HIV-1 genomic RNA (gRNA) delay CA-SP1 processing. SL1 harbours the dimerisation initiation site (DIS) palindrome suggesting that efficient Gag …
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Function and Regulation of Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex1) in Cancer
… and associate with the P-Rex1 promoter. One Sp1 site, essential for basal promoter activity, was identified as critical for the TSA effect. TSA treatment did not alter the DNA-binding activity of Sp1 toward the P-Rex1 promoter; however, it facilitated the dissociation of the repressive HDAC1 …
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Modelling, simulation, and control of robots
… and the linearized model is used to design $l\sp1$ optimal controllers for the robot. The Multi Input Multi Output optimization problem splits up into decoupled Single Input Single Output problems which are individually solved. Optimal systems thus designed are simulated and compared to …
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Femtosecond laser studies of molecular wavepacket dynamics in the cesium dimer
… laser pulses. Specifically, pumping the $\rm C(\sp1\Pi\sb{u})\gets X(\sp1\Sigma\sb{g}\sp+)\ Cs\sb2$ band at several wavelengths between 627 nm and 650 nm produces a wavepacket with an oscillation period of $\sim$1.15 psec. The wavepacket is detected by photoionizing the excited molecule with a …
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