Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Sox6"”.
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Analysis Of The Mouse p100H Mutation: Implications For Two Disease Related Genes: P and Sox6
… inversion that disrupts both the p gene and Sox6. The human counterparts of these two murine genes are either known to cause human disease (human P gene) or have potential implications in developing a new strategy to treat human disease (SOX6).In the first part of my dissertation (Chapter …
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Transcriptional Regulation of Muscle Contractility and Metabolism by a MicroRNA-Mediated Feed Forward Loop
… negatively regulating the transcription factor Sox6, in addition to several other functionally related transcriptional repressors. Subsequent studies identified Sox6 as a fast myofiber enriched repressor of slow muscle gene expression. Mice lacking Sox6 specifically in skeletal muscle have an …
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ROLE OF MICRORNAS IN THE PATHOGENESIS OF ATOPIC DERMATITIS
… software and luciferase assay, we identified SOX6 and CASP7 as novel bona fide targets of miR-335. Both SOX6 and CASP7 were found to be overexpressed in AD skin. SOX6 was shown to regulate keratinocyte differentiation, while CASP7 may regulate skin immune regulation. In conclusion, our results …
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Implication du facteur de transcription SOX9 dans la régulation du gène de la furine lors de la différenciation de la lignée chondrocytaire ATDC5
… le gène de la furine est inhibée par L-Sox5 et Sox6, deux facteurs de transcription homologues impliqués dans la différenciation des chondrocytes. L'effet inhibiteur de Sox6 est levé lorsqu'une version mutée, exempte du domaine de liaison à l'ADN de type HMG fonctionnel, est utilisée. Ceci …
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CONNECTIVE TISSUE GROWTH FACTOR IS REQUIRED FOR CHONDROGENESIS
… of known early chondrogenic markers (sox9, sox6, l-sox5, type II collagen, aggrecan, decorin and link protein). Real-Time PCR, Western blot and Immunofluorescence reveal that CCN2 is required for the early stages of chondrogenesis, including expression of sox6 and aggrecan, but not type II …
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Genetic dissection of EGFRvIII brain and spinal mouse gliomas through whole-exome sequencing and in vivo piggyBac mutagenesis forward genetic screening
… that regulate neuronal differentiation such as Sox6 and Tcf12, and a novel regulator of the Ras pathway Spred1. RNA-sequencing confirmed the presence of fusion transcripts (transposon mediated effects) for these genes. We demonstrate the clinical relevance of these cooperative genes through …
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Caractérisation de l'expression et de l'activité des facteurs SOX dans le testicule adulte de souris
… et que les transcrits des facteurs Sox5, Sox6 et Sox30 sont présents dans les spermatocytes et les spermatides." Mots clés : Testicule, Sertoli, Leydig, Cellules germnales, Transcription, SOX, SOX4, SOX8, spermatogénèse, Stéroïdogénèse.--Sommaire.
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Bone growth following demineralized bone matrix implantation requires angiogenesis
… to progress based on the failure of Sox5 and Sox6 expression, which directs chondrocyte commitment. This expands the role for angiogenesis to a much earlier stage than currently thought and places the necessity of angiogenesis very early in the endochondral ossification process.
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Derivation of next generation research models of Parkinson’s disease
… of (ATOH1 or NGN2), FOXA2, LMX1A, NURR1, PITX3, SOX6, and MSX1 revealed three distinct TH-positive neuronal clusters. However, these neurons were also found to be positive for PRPH, a peripheral nervous system marker. The characterization of TH-positive neurons induced by ATOH1 alone, with or …
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Identifying circulating biomarkers in a cohort of hypercholesterolaemic patients with statin intolerance from Gauteng, South Africa
… using TargetScan of note is FOXO4, PDCD4 and SOX6, which all are genes associated in pathways related to regulation of smooth and skeletal muscle cell differentiation. Quantitative polymerase chain reaction (qPCR) was used to determine the levels of miR-33a, miR-133a and miR-499a, …