Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Sorting Motifs"”.
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Recognition of basic sorting motifs within synaptic membrane cargo proteins by the clathrin-adaptor complex AP-2
Kommunikation im zentralen Nervensystem erfolgt über chemische Synapsen, die interzelluläre, asymmetrische Verbindungen zwischen einem Axon und dem Dendriten eines benachbarten Neurons darstellen. Synapsen bestehen aus einer präsynaptischen Signal freisetzenden und einer postsynaptischen Signal …
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An Investigation into the Intracellular Trafficking and Processing Pathways of Amyloid Precursor Protein
… tail of APP contains several tyrosine-based sorting motifs that are believed to direct its trafficking. Using a kinetic trafficking assay, these motifs have been systematically mutated and quantitatively assessed for their impact on anterograde APP processing. The effects of FAD APP mutations …
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Investigating the trafficking of Golgi-resident glycosylation enzymes
The Golgi is a major site of glycan processing mediated by a large number of Golgi-resident glycosylation enzymes. These enzymes are largely type II transmembrane domain (TMD) proteins consisting of a short N-terminal cytosolic tail, a short TMD and a lumenal ‘stem’ region which separates the …