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Showing 1 to 7 of 7 for “"Sonogashira cross-coupling"”.
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Design, Synthesis and Study of Novel Nucleobase Analogs
… analogs were successfully synthesized via the Sonogashira cross-coupling reaction of 7-iodo-7-deaza-2´-deoxyadenosine with 1-ethynylpyrene, 2-ethynyl-6-methoxynaphthalene, and 9-ethynylphenanthrene. These analogs were photophysically characterized in dioxane, EtOH, and H2O to evaluate their …
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Advances in the synthesis of indazoles: regioselective C-7 functionalization by directed ortho metalation and progress towards indazole based azaborine compounds
… enabled the subsequent Suzuki-Miyaura or Sonogashira cross coupling reactions to prepare C-3 substituted indazoles. Efforts in Directed ortho Metalation (DoM) reactions at the C-3 aryl groups of substituted indazoles towards azaborine targets were unsuccessful. Internal alkyne bearing …
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Investigations into the Synthesis of InherentlyChiral Calix[4]arenes
… We were able to obtain AABC compounds via Sonogashira cross-coupling. For the ABCD compounds, the first step of the synthesis begins via a Suzuki-Miyuara coupling of the bis-1,3-aldehyde-bis-2,4-iodo calix[4]arene with a variety of boronic acids affording mono-aryl and di-aryl compounds, …
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Synthesis and functionalization of novel meso-substituted tetrabenzotriazaporphyrins
… by the nickel or palladium catalysed Kumada cross-coupling reaction using 1,2-dichlorobenzene as precursor, followed by electrophilic bromination and Rosenmund von Braun cyanation reaction in the last step. An alternative route towards the formation of the phthalonitriles was used in order to …
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Synthesis and Biological Investigation into the Metabolism of Retinoids
… uncharged molecules to limb buds is required. Sonogashira cross coupling reactions were employed to synthesise ether acetate analogues of EC23 and EC19, (EC23 OAc and EC19 OAc) from TMNA with acetic acid 4-bromo-benzyl ester and acetic acid 3-iodo-benzyl ester respectively, with the intention …
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The conjugation and evaluation of hydrophobic small molecules to trazole-linked siRNAs
… cholesterol and phenylacetylene utilizing the Sonogashira cross-coupling reaction. Subsequent reactions were performed on the dimer to give rise to a 4,4’-dimethoxytrityl (DMT)-protected phosphoramidite building block, which allowed for its site-specific incorporation into an oligonucleotide …
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Synthesis of Highly Ordered Polymer Nanostructures Based on Polyphenylene Vinylenes (PPVs)
… up high molecular weight materials via efficient Sonogashira cross-coupling polymerizations and then convert those benign materials into more custom materials via new aryl-aryl bonding after cyclopentannulation.