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Showing 1 to 20 of 64 for “"Sonogashira"”.
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Új, vízoldható Pd-katalizátorok alkalmazása Sonogashira-kapcsolásban
… a komplexek katalitikus aktivitását vizsgáltam Sonogashira kapcsolási reakcióban. A reakciókörülmények optimalizálása érdekében tanulmányoztam különböző szerves és szervetlen bázisok hatását a reakcióra, vizsgáltam a szubsztrátum/bázis és a szubsztrátum/katalizátor arány reakcióra gyakorolt …
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Multi-component Reactions Initiated via Sonogashira Coupling
… in appropriate positions can be subjected to Sonogashira coupling with terminal alkynes, producing internal alkynes that can now undergo a Michael addition with suitable secondary amines. This coupling-aminovinylation sequence can be performed in a one-pot fashion, providing a straightforward …
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Multicomponent Heterocycle Syntheses Based upon Sonogashira Coupling-Isomerization
Die Studien zur Optimierung der Kupplungƒ{Isomerisierungsƒ{Reaktion (KIR); Eintopf, MultikomponentSynthese von Heterozyklen
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A. Discovery of novel reactivity under the Sonogashira reaction conditions B. Synthesis of functionalized BODIPYs and BODIPY-sugar conjugates
… alkynes and 1,2-cis-dihaloalkenes under the Sonogashira reaction conditions failed to give the corresponding substituted enediynes. Under these conditions, terminal alkynes underwent self-trimerization or tetramerization. In an alternative approach to access substituted enediynes, treatment …
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Sonogashira coupling reactions in the synthesis of near infra-red emitters and of star systems for the study of charge propagation in dendrimers
"Sonogashira coupling reactions have been used for the synthesis of three functional systems: arylethynyl-substituted 9,10-anthraquinones, Os(II) bis(2,2'-bipyridine) (3,8-diarylethynyl-1,10-phenanthroline) complexes and four star-shaped molecules incorporating the 4-benzoyl-N-alkylpyridinium …
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Titankatalysierte Hydroaminierung von Alkenen und Alkinen in der Wirkstoffsynthese
… des A- und C-Rings erfolgte durch eine Sonogashira-Reaktion. Der B-Ring wurde durch eine intramolekulare Hydroaminierung aufgebaut. Die so gewonnenen 1-Benzyl-3,4-dihydroisochinolin-Derivate wurden direkt zu den 1-Benzyl-1,2,3,4-tetrahydroisochinolin-Derivaten reduziert oder zu den …
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Part I: The synthesis of chenodeoxycholic acid derived macrocyles and cage compounds. Part II. Sonogashira coupling for the synthesis of well-defined π-conjugated arylene ethynylene oligomers as blue-light-emitting materials
… been successfully synthesized using oxygen-free Sonogashira reaction conditions. The structures of these oligomers have been confirmed by 1H and 13C NMR spectroscopy, HR-MS, MALDI-TOF spectroscopy. The detailed structure of oligomers 5a, 5b and homo4 were revealed by single X-ray crystal …
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The Application of the Titanium-Catalyzed Hydroamination of Alkynes toward the Synthesis of Benzylisoquinoline Derivatives
… coupling aryl iodide 115 and alkyne 121 using a Sonogashira reaction. Dihydroisoquinoline 124 was obtained by intramolecular hydroamination of the aminoalkyne 123. Employing Noyori´s reduction protocol, the absolute configuration at C-1 of the benzylisoquinoline was introduced with 93% ee. …
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Synthese von einkernigen und mehrkernigen Übergangsmetall-Komplexen als Katalysatoren für die Ethenpolymerisation und die Ethen/1-Hexen-Copolymerisation
… die in verschiedenen Kupplungsreaktionen (z.B. Sonogashira- oder Heck-Kupplungsreaktionen bzw. Hydrosilylierungsreaktionen) zur Synthese mehrkerniger Komplexe verwendet werden können. Zunächst wurden Heck- und Sonogashira-Kupplungsreaktionen genauer betrachtet. Dazu wurden iodsubstituierte …
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Synthesis of 3-aminocyclobutenones via [2 + 2] cycloaddition of ynamides and ketenes
… of the requisite halo diynes is achieved by Sonogashira coupling followed by base-mediated elimination at low temperature.
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Design, Synthesis and Study of Novel Nucleobase Analogs
… analogs were successfully synthesized via the Sonogashira cross-coupling reaction of 7-iodo-7-deaza-2´-deoxyadenosine with 1-ethynylpyrene, 2-ethynyl-6-methoxynaphthalene, and 9-ethynylphenanthrene. These analogs were photophysically characterized in dioxane, EtOH, and H2O to evaluate their …
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Synthesis and Photophysics of Varied Substituted DPNDs for Potential PDT Applications
… tBu-DPND–1 (β-Suzuki), tBu-DPND–1 (β-Sonogashira), and tBu-DPND–3 (α-Sonogashira), were prepared and characterized using advanced photophysical methods to unveil how π-conjugation and topology influence excited-state dynamics. Furthermore, we varied the polarity of the samples to shed …
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Pyrrolo[2,3-d]pyrimidine-based π-conjugated fluorophores with 1,2,3-triazole and ethynyl linkers: synthesis and photophysical properties /
… from 402 nm to 650 nm. A comparative study of Sonogashira and Stille reactions as well as Suzuki and Stille reactions for the introduction of alkynyl and aryl moieties onto pyrrolo[2,3-d]pyrimidine has been carried out. The synthesis of pyrrolo[2,3-d]pyrimidine oligoarylenes bearing different …
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Pirolo[2,3-d]pirimidino π-konjuguotų fluoroforų, turinčių 1,2,3-triazolo ir etinil jungtukus, sintezė ir fotofizikinės savybės /
… from 402 nm to 650 nm. A comparative study of Sonogashira and Stille reactions as well as Suzuki and Stille reactions for the introduction of alkynyl and aryl moieties onto pyrrolo[2,3-d]pyrimidine has been carried out. The synthesis of pyrrolo[2,3-d]pyrimidine oligoarylenes bearing different …
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Síntese e propriedades fotofísicas de novos cristais líquidos luminescentes contendo os heterociclos 1,2,4-e/ou 1,3,4-oxadiazóis
… cruzado mediado por paládio (acoplamento Sonogashira) entre os intermediários 25c e 29-33 para a obtenção de 15uma diferente rota foi adotada. Todos os compostos sintetizados exibiram mesofases N, SmC e SmA típicas de CLs calamíticos, boa estabilidade térmica e altos rendimentos quânticos …
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Targeting the p53/MDM2 protein-protein interaction
… present in the natural product chlorofusin. The Sonogashira precursor used to generate azaphilone analogues was synthesised using a methodology adopted by Porco et al and subsequent analogues were generated using a novel double-Sonogashira approach followed by functionalisation published by Boger …
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Chemoselective and Stereoselective Exploration of the Chemical Reactivity Space of Castagnoli-Cushman-Derived Allylic Lactamoyl Esters: Application to the Synthesis of Aza-Polycyclic Architectures
… in cross-coupling manifolds (<em>e.g.</em>, Sonogashira coupling) and concomitant lithiation-cyclization of the tethered alkyne. An unprecedented example of a hydroamino alkylation that is transition metal-free and occurs at room temperature will also be discussed.
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Part I: Rapid Synthesis of Dendrimers by an Orthogonal Coupling Strategy. Part II: Design, Synthesis, and Characterization of Hydrogen-Bond Mediated Self-Assembling Dendrimers
… 66 and 67 under Mitsunobu esterification and Sonogashira coupling conditions. Further accelerated growth was achieved by merging the orthogonal coupling strategy with Frechet's branched-monomer approach. Thus, sixth generation dendron 81, with molecular formula $\rm …
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Design and synthesis of novel biologically active flavones and isoflavones
… which were introduced at the terminal alkyne via Sonogashira coupling. The intramolecular cyclization was carried out through an electrophilic borylative reaction followed by immediate esterification to furnish the benzopyran core with a boronic ester at 3-position. Subsequent Suzuki-Miyaura …
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Probing the HIV Reverse-Transcriptase enzyme with novel bifunctional HIV-1 RT inhibitors of the general formula (NRTI)-spacer-(NNRTI)
… for the target bearing PEG-propyne units using Sonogashira coupling methodology as a key step. Chapter Three describes the second series incorporating a new NNRTI in the form of 2- and 4- pyrimidinylarylamine motifs. Key features in this chapter include the synthesis of tri-substituted anilines, …
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