Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Sonic Hedgehog"”.
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Targeting c-met in sonic hedgehog medulloblastomas
… of four molecular subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and Group 4. Although the 70-75% of MB patients survive the disease, the current therapeutic regimen, which comprises surgical resection, chemotherapy and cranial irradiation, is worryingly associated with severe side …
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The Role of Sonic Hedgehog in the Hypothalamus
ABSTRACT THE REQUIREMENT OF SONIC HEDGEHOG IN THE HYPOTHALAMUS Solsire E. Zevallos Douglas J. Epstein Sonic hedgehog (Shh) is a morphogen secreted during early development that is required for the formation of the ventral neural tube, including the ventral forebrain. The prechordal source of Shh …
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Astrocytic Sonic Hedgehog signalling in development and disease
Sonic hedgehog (Shh) signalling is a critical pathway in embryonic development, with known roles in cell differentiation, tissue patterning, and the establishment of body axes (Rowitch et al., 1999; Echelard et al., 1993; Ericson et al., 1997; Jessel and Lumsden, 1997). Beyond these canonical …
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Sonic hedgehog signaling pathway in normal and adenomatous pituitary
… the first time the expression and the role of Sonic hedgehog signaling pathway in adult pituitary and in pituitary tumors. Shh is a signaling protein, important in regulating patterning and proliferation in the embryo and the adult. It has a crucial role in pituitary development and Shh …
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The Role of Sonic Hedgehog in Outflow Tract Development
… signaling pathways. One of these pathways is the Sonic hedgehog pathway. This thesis tests the hypothesis that Sonic hedgehog induces secondary heart field proliferation, which is necessary for normal outflow tract development. To address this hypothesis, I took advantage of small chemical …
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The Misexpression of Sonic Hedgehog Leads to Digit Duplication
… activity (ZPA). The secreted molecule, sonic hedgehog (Shh) is produced by the cells of the ZPA and has been shown to play an important role in this process of pattern formation. Grafting the cells of the ZPA onto developing host tissue induces mirrorimage limb duplication. In addition …
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Ο ρόλος του σηματοδοτικού μονοπατιού Sonic Hedgehog στον καρκίνο του πνεύμονα
… έγινε μελέτη του σηματοδοτικού μονοπατιού Sonic Hedgehog σε 96 περιστατικά καρκίνου πνεύμονα με τη μέθοδο της ανοσοϊστοχημείας. Επίσης μελετήσαμε την πιθανή συμμετοχή του μεταγραφικού παράγοντα FoxM1 στο καρκίνωμα του πνεύμονα και την πιθανή συσχέτισή του με το μονπάτι του Hedgehog. Έγινε …
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Role of Sonic Hedgehog in Development of the Central Nervous System
Sonic hedgehog (Shh) functions as a morphogen to induce early dorso-ventral patterning of the central nervous system (CNS) and specifies cell fates of spinal motor neurons. Shh has also been known to promote cell cycle progression of embryonic stem cells as well as adult neural stem/progenitor …
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Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
Sonic hedgehog (Shh) is a member of the hedgehog family of signalling molecules and secreted from two signalling centers, the notochord and the floor plate, where it functions as a morphogen to induce early dorso-ventral patterning of the cenral nervous system (CNS). More recently, multiple actions …
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Dynamic visualization and genetic determinants of Sonic hedgehog protein distribution during zebrafish embryonic development
… Among these, proteins belonging to the Hedgehog (Hh) family have received much attention, owing to their unusual double lipid modification and their involvement in human disease, causing congenital birth defects and cancer. Great efforts have been made in order to elucidate the …
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The Generation of Alternative Transcripts as a Means of Regulating Phosphorylation in Sonic Hedgehog Medulloblastoma
… mechanism for regulation at the mRNA level. The sonic hedgehog (SHH) subtype of medulloblastoma (MB), the most common malignant pediatric cerebellar tumor, arises from granule neuron precursors (GNPs) through aberrant SHH signaling. Murine postnatal day 7 (P7) GNPs are highly proliferative and …
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Removal of Pax6 from cortical progenitors renders them abnormally likely to switch fate in response to Sonic Hedgehog activity
… are also regulated by morphogens such as Sonic Hedgehog (Shh) that promotes ventralization of the ventral telencephalon (vTel), through diffusion to form a concentration gradient. Strikingly, when Pax6 is deleted, a subset of cortical progenitor cells that would normally become …
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The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells
… in granule cells in the cerebellum. The sonic hedgehog (SHH) and N-Myc pathways are important for granule cell precursor proliferation and differentiation. The project tests the hypothesis that the proliferation defect of granule cells is associated with SHH - N-Myc pathway impairment in …
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The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
Neural tube is a structure within the developing vertebrate embryo that gives rise to the central nervous system consisting of the brain and the spinal cord. Within the neural tube, there are pools of specific neural progenitors that give rise to specialised types of neurons. Those progenitors are …
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Limbs gone batty : the role of the anterior-posterior patterning signal, Sonic Hedgehog, in the development of the unique bat limb
… of the anteriorposterior patterning signal, Sonic hedgehog (Shh), and its downstream target, Patched 1 (PtcJ), have contributed to the development of the unique bat limb. The embryonic development of Miniopterus natalensis (Miniopteridae) is described for the first time and the expression …
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Multiple roles of epithelial signaling during craniofacial and foregut morphogenesis
… epithelium. The mesenchyme needs to receive Hedgehog signaling for mandible development, but the epithelial tissue that signals to the mesenchyme has not been identified in mammals. Data presented in Chapter 2 show that Sonic Hedgehog is necessary at two distinct stages of mandible …
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A multi-dimensional microfluidic platform recapitulating chemotactic and morphogenic chemical gradients
… able to probe the role of Wnt signaling during Sonic Hedgehog based patterning of the vertebrate ventral neural tube. Using the presumptive enhancer for the p3 progenitor domain gene Nkx2.2, our findings indicate that such an enhancer would both negatively and positively regulate Nkx2.2 …
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SUFU in SHH signalling mediated myogenesis
… signalling pathways. Among these include the Sonic hedgehog (Shh) signalling pathway which must be deactivated for differentiation into muscle cells to occur. However, less is known regarding the pathways operation during cell differentiation and whether Suppressor of Fused (SUFU), the protein …
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Guidance of Developing Motor Neurons into the Periphery
… The development of all MNs subtypes begins with Sonic Hedgehog (Shh) signaling in the spinal cord and then progresses to increasingly specific guidance signaling systems. MN subtypes are classified by the combined activities of transcription factors and molecular signaling systems that determine …
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