Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Somites"”.
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A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
Somites are repeated epithelial segments that are generated in a rhythmic manner from the presomitic mesoderm (PSM) in the embryonic tailbud. Later, they differentiate into skeletal muscle, cartilage and dermis. Somitogenesis is regulated by a complex interplay of different pathways. Notch/Delta …
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Investigation of cell movement and the associated cytoskeleton during chick gastrulation and somitogenesis
… lie either side of the neural tube separate into somites. As new somites form caudally, the more rostral somites undergo a process of morphogenesis. Each somite divides into two regions: the dermomyotome and the sclerotome. Little is known about the cytoskeletonduring this process. Signalling by …
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Analysis of the Zebrafish Segmentation Clock
… blocks of tissue flanking the notochord called somites. Somites are generated sequentially and periodically from an unsegmented tissue called the presomitic mesoderm (PSM) by a process called somitogenesis. <br></br><br></br> Underlying the periodicity of somitogenesis are transcriptional …
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The Molecular Regulation of Spinal Nerve Outgrowth
… formation of multipotent structures called somites. Somites differentiate subsequently into dermomyotome (giving rise later to skin and skeletal muscles) and sclerotome (giving rise to vertebral bone structures and cartilage). In addition, sclerotomes subdivide following their rostro-caudal …
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The roles of T and Tbx6 during gastrulation and determination of left/right asymmetry
… T homozygous null mutants lack posterior somites after the seventh pair, have no distinguishable notochord, have a convoluted neural tube and die at E.10.5. In this study we investigate the phenotype of a dominant negative allele of T, TWis. Like homozygous embryos carrying the null allele …
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Role of Xenopus Pitx3 during early development.
… lateral plate mesoderm, branchial arches, somites, and asymmetrically in looping gut. Ectopic expression assays suggest that xPitx3 directs development of the optic placode, and that without its influence; both the lens and retina fail to form. xPitx3 over-expression expands the early …
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Molecular and biochemical characterisation of phosphorylation-dependent NICD1 turnover: novel roles for CDK1 and CDK2
… species-specific manner through the formation of somites, which later give rise to the vertebral column, most skeletal musculature and dermis. Somites are gradually and periodically pinched off from the anterior end of the presomitic mesoderm (PSM). The rhythmicity of somitogenesis is regulated by …
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Investigating the relationship between clock gene stability and the pace of the vertebrate segmentation clock
Somites are precursors of the vertebrae, ribs, and associated musculature and their formation relies on ordered and timely segmentation during early embryonic development. Somites form as they ‘pinch’ away from the pre-somitic mesoderm (PSM) with a species-specific periodicity, coinciding with …
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Régulation de voies de signalisation par deux acteurs de la voie Nonsense-mediated Decay, Dhx34 et Nbas: la cas particulier de l'adénohypophyse.
… developmental defects mainly in brain, eyes and somites. Moreover, it’s has been showed that as in mammals the NMD in fish also implicated in the regulation of natural transcripts. We present here a functional study of two key actors of the NMD, Dhx34 and Nbas, in the interesting case of the …
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Novel Notch signalling dynamics within the molecular oscillator underlying vertebrate segmentation
… in embryonic development by the formation of somites, epithelised balls of tissue from which many of the axial tissues of the adult organism are derived. Produced during the process of somitogenesis, somites periodically bud off in pairs with strict, species-specific periodicity from an area …
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Cell Migration and Morphogenesis during Formation and Repair of Zebrafish Skeletal Muscle
… to adjacent slow muscle fibres from neighbouring somites and are polarized anteroposteriorly and mediolaterally and gravitate towards the anterior somite half during their migration. Somite borders are shown to be not necessary for slow muscle fibre migration but for slow muscle fibre polarisation …
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The evolution of somitogenesis: Mechanisms of paraxial mesoderm elongation in zebrafish and other vertebrates
… segmentation of the paraxial mesoderm to form somites. Although the segmentation aspect of this has been widely studied, the elongation aspect is not well understood. Posterior growth is widely assumed to be the main driver, but there is very little evidence for this – particularly in …
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The Role of the Ca2+-dependent protein kinase, CaMK-II, in Heart and Kidney Development in the Zebrafish, Danio rerio
… diverse tissues including retina, pectoral fins, somites, heart, and kidney. Suppression of each gene generates unique phenotypes that mirror the mRNA expression patterns. Of the seven genes, camk2b2 and camk2g1 have the highest maternal contribution in zebrafish, are expressed in mesodermally …
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Investigating the role of Klhl31 in striated muscle
… for the induction of myogenesis in the somites and is slightly delayed compared to the expression of early myogenic regulatory factors. With this study we wanted to analyse the function of Klhl31 during myogenesis in more detail. Using C2C12 mouse myotubes as our model cell line to study …
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Investigating non-canonical vertebral development in the zebrafish model system
… and chicks – amniotes – a subpopulation of the somites, the sclerotome, is sole source of vertebral tissue. It is unclear, however, how applicable this amniote-based ‘canonical’ mechanism is across the vertebrates. In fact, the vast majority and diversity of vertebrates are not amniotes, but are …
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The Regulation of Segmentation Clock Period in Zebrafish
… axis into epithelial spheres of cells called somites. This rhythmic process is thought to be driven by a multicellular oscillatory gene network, the so-called segmentation clock. Oscillations of hairy and enhancer of split gene products have been proposed to constitute the core clockwork in …
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Charakterisierung der Selenoproteine Thioredoxinreduktase 1 und 2 anhand von Knock-out-Mausmodellen
… formation of head structures and formation of somites. Thereby TR1 deficient embryos maximally reach the developmental stage of normal E8.5 wildtype embryos. Neuronal specific TR1 knockout mice show growth retardation and cerebellar hypoplasia. Starting at the postnatal age of 10-14 days they …
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Visualizing Cell Migration in Situ
… outgrowth from the slice. Muscle precursors, in somites, initiate migration synchronously and migrate in broad, rather than highly defined, regions. Bursts of directed migration are followed by periods of meandering and protrusiveness. Introducing cDNAs encoding GFP-fusion proteins demonstrate …
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Notochord morphogenesis as a mechanical driver of embryo axis elongation
… by the somitic compartment made up of developing somites in the segmented region of the axis and presomitic mesoderm in the posterior. Therefore, it is appropriately positioned to play a role in mechanically elongating the somitic compartment. In this PhD thesis I characterise axis elongation and …
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Pax3 expression in satellite cells of avian skeletal muscle spindles during normal development and with experimental muscle overload
… expressed in the dermomyotome of embryonic somites, which gives rise to skeletal muscle. Following myogenesis, Pax3 expression is mostly down-regulated and becomes restricted to a few satellite cells (SCs) of select mature muscles. SCs are activated to form new myonuclei during muscle …
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