Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Somatic point mutations"”.
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Quantitative analyses to study tumor clones dynamics and tumor heterogeneity
… hoc computational procedure (ABEMUS) to detect somatic point mutations that could emerge under treatment pressure and as drug resistance mechanism. The work I present is relevant to the context of precision oncology that exploits detailed patient-specific molecular information to diagnose and …
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Unleashing the potential of liquid biopsy: allele-informed evaluation of plasma samples for cancer patients management
… designed for cfDNA samples to accurately detect somatic point mutations that could emerge under treatment pressure and as drug resistance mechanism. When applied on serial plasma samples from three patients receiving PARP inhibition harboring DNA repair gene aberrations, PCF_SELECT demonstrated …
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Automatic Tumour Typing based on Patterns of Somatic Passenger Mutations
… strong associations between cancer type and somatic mutations, prompting the use of somatic mutations as a tool for identifying cancer type. While existing approaches have attempted to use cancer-associated mutations, which may be more common in specific cancer types to infer the primary …
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Analysis of alterations in the human cancer genome
… genomic characterization techniques measure somatic alterations in a cancer sample in units of genomes (DNA mass). The meaning of such measurements is highly dependent on the tumors purity and its overall ploidy; they are hence complicated to interpret and compare across samples. Ideally, …
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Understanding and Improving Identification of Somatic Variants
… important to understand the entire spectrum of somatic variants to gain more insight into mutations that occur in different cancers for development of better diagnostic, prognostic and therapeutic tools. This thesis outlines our work in understanding somatic variant calling, improving the …