Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1128 for “"Somatic"”.
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Modularity in Somatic Cell Reprogramming
… of human disease. However, reprogramming human somatic cells is an inefficient and nebulous, ill-defined process, and thus to benefit from the potential of iPS cell technology, it is essential to understand the mechanisms underlying cell fate transitions. Here, I explored the transcriptome …
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Somatic embryogenesis in Pinus radiata
Somatic embryogenesis of Pinus radiata has been seen as an attractive alternative to traditional propagation methods. This is due to its potential for high multiplication rates and rejuvenation, as well as its compatibitity with molecular techniques. To date no commercial production of somatic …
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Symptomatic Cambodia veterans: somatic aspects
Contains fulltext : mmubn000001_347620396.pdf (Publisher’s version ) (Closed access)
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Somatic cell interspecies nuclear transfer
… This resulted in the first scientific report of somatic cell NT, in vitro culture and transfer of NT embryos in the llama. In the next experiment, adult horse and llama fibroblasts were injected into enucleated cow oocytes. The results showed the cow cytoplasm is capable of partially …
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Culture and Somatic Focused Attention
… Ghanaian and American university students in somatic-focused attention were explored. Study 1 showed that Ghanaian participants paid more attention to their body and less to emotions than did American participants. However, these differences were not explained by differences in …
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Epigenetic Heritability in Somatic Cells
Across the lifespan, cells accumulate somatic mutations, epigenetic alterations, tran- scriptional noise, mitochondrial damage and irreversible protein aggregation, the so-callled hallmarks of ageing. These molecular changes tend to worsen and compound over time, yet the mechanism through which …
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Sensitive skins and somatic processing for affective and sociable robots based upon a somatic alphabet approach
The sense of touch is one of the most important senses of the human body. This thesis describes the biologically inspired design of "sensitive skins" for two different robotic platforms: Leonardo, a high degree-of-freedom, sociable robot and the Huggable, a portable therapeutic robotic companion …
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Novel Regulators of Somatic Cell Reprogramming
Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by expression of defined embryonic factors. My thesis is focused on exploring the mechanisms underlying reprogramming using a secondary mouse embryonic fibroblast model that forms iPS cells with high efficiency upon inducible …
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PROPAGATION OF PLANTS BY SOMATIC EMBRYOGENESIS
… would be reduced by utilising the phenomenon of somatic embryogenesis for plant regeneration (Jones, 1984, Biochem. Soc. Symp. 98: 222-232). Although many publications describe how mbryogenesis may be induced in particular cases (reviewed by Williams and Maheswaran, 1986, Ann. Bot. 57: 449-462), …
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Somatic cell nuclear transfer in zebrafish
Thesis (Ph. D.)--Michigan State University. Comparative Medicine and Integrative Biology, 2010
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Somatic Mutations in Primary Sjögren’s Syndrome
Somatic Mutations in Primary Sjögren’s Syndrome Aleksandra Ivovic Despite decades of research and many insightful findings, a complete understanding of the pathogenesis of autoimmune diseases continues to elude us. In this thesis, I explore the hypothesis that somatic mutations may underpin the …
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Somatic evolution in normal human endometrium
… malignant transformation. Our understanding of somatic evolution occurring in normal tissues with age and in the early stages of tumourigenesis remains relatively poorly understood. In this thesis, I aimed to investigate somatic evolution in normal ageing human tissues. Firstly, I helped to …
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Somatic retrotransposition in the cancer genome
… complex disease of the genome exhibiting myriad somatic mutations, from single nucleotide changes to various chromosomal rearrangements. The technological advances of next-generation sequencing enable high-throughput identification and characterization of these events genome-wide using …
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IN/VISIBLE: Architecture as Somatic Experience
IN/VISIBLE: Architecture as Somatic Experience investigates how architecture can emerge from the body’s own modes of sensing—what this thesis defines as somatic sensory intelligence. Rather than treating ramps as residual infrastructure for accessibility, the project positions them as primary …
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Polyclonal somatic mutations in health and disease
[Restricted]
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Somatic Mutations in Ageing and Degenerative Disease
Following the first division of the zygote, somatic mutations begin to accumulate in all human cells. Daughter cells become increasingly mutated leading to mosaic tissues, composed of genetically heterogeneous clonal units. In recent years, large scale sequencing efforts have begun to characterise …
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Somatic mosaicism in development and paediatric cancer
… of trillions of cells in adulthood, these somatic mutations are acquired throughout life either via endogenous errors in DNA replication or environmental DNA damage factors. Most of these somatic mutations land in the vast noncoding intergenic regions of the genome, marking cell lineage but …
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Somatic evolution in human blood and colon
… through the chance acquisition of particular somatic mutations that gave them a selective advantage over their neighbours. Thus, the mutations that initiate cancer occur in normal cells, and the normal clonal dynamics of the tissue determine a mutant cell’s ability to establish a malignant …
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Understanding and Improving Identification of Somatic Variants
… important to understand the entire spectrum of somatic variants to gain more insight into mutations that occur in different cancers for development of better diagnostic, prognostic and therapeutic tools. This thesis outlines our work in understanding somatic variant calling, improving the …
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SOMATIC SIGNALS REGULATING MRNA TRANSLATION IN MAMMALIAN OOCYTE.
In oocytes, resumption and completion of meiosis I are driven by post-transcriptional mechanisms on a background of repressed mRNA transcription. However, a comprehensive understanding of this regulation in higher-order mammals has been limited by challenges in isolating polysome-associated mRNAs. …
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